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View Structure Prediction Details

Protein: YPL245W
Organism: Saccharomyces cerevisiae
Length: 454 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YPL245W.

Description E-value Query
Range
Subject
Range
YP245_YEAST - Uncharacterized protein YPL245W OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YPL245W ...
gi|207340752 - gi|207340752|gb|EDZ69002.1| YPL245Wp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190407720 - gi|190407720|gb|EDV10985.1| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a]
YPL245W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to bo...
0.0 [1..454] [1..454]
gi|238833802, gi... - gi|238853584|ref|ZP_04643954.1| AbiBL11 [Lactobacillus gasseri 202-4], gi|238833802|gb|EEQ26069.1| A...
gi|116629978, gi... - gi|23003678|ref|ZP_00047332.1| hypothetical protein Lgas_03001717 [Lactobacillus gasseri ATCC 33323]...
gi|23003678 - gi|23003678|ref|ZP_00047332.1| COG3410: Uncharacterized conserved protein [Lactobacillus gasseri]
gi|226819985 - gi|226819985|ref|ZP_03809104.1| hypothetical protein LgasM_04989 [Lactobacillus gasseri MV-22]
0.0 [27..454] [1..403]
gi|28377274, gi|... - gi|28377274|ref|NP_784166.1| hypothetical protein lp_0359 [Lactobacillus plantarum WCFS1], gi|282701...
gi|254555490, gi... - gi|254555490|ref|YP_003061907.1| hypothetical protein JDM1_0321 [Lactobacillus plantarum JDM1], gi|2...
0.0 [25..451] [3..398]
gi|7480499 - pir||T29128 probable ATP/GTP binding protein - Streptomyces coelicolor
gi|3451451, gi|2... - gi|3451451|emb|CAA20510.1| putative ATP/GTP binding protein [Streptomyces coelicolor A3(2)], gi|2122...
0.0 [4..451] [201..617]
gi|29828357, gi|... - gi|29828357|ref|NP_822991.1| ATP/GTP-binding protein [Streptomyces avermitilis MA-4680], gi|29605460...
0.0 [4..452] [201..618]
gi|23023875, gi|... - gi|23023875|ref|ZP_00063104.1| COG3410: Uncharacterized conserved protein [Leuconostoc mesenteroides...
0.0 [40..453] [14..386]
gi|10644758 - gi|10644758|gb|AAG21387.1|AF302051_1 AbiBL11 [Bacillus licheniformis]
0.0 [34..438] [153..528]
gi|25394369 - pir||B90289 conserved hypothetical protein [imported] - Sulfolobus solfataricus
gi|13814539, gi|... - gi|15898174|ref|NP_342779.1| hypothetical protein SSO1331 [Sulfolobus solfataricus P2], gi|13814539|...
2.0E-93 [37..453] [201..602]

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Predicted Domain #1
Region A:
Residues: [1-214]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHGPTSKAIS RNVRSVKRPR RAPRPVVSTQ AMNKLSNVTL SAEQEKLRER VLSFMRSNLS  60
   61 QYKSDWKHPA MFVIQGDAGT GKSVILNSLF NEIQKLSQFS PSSEDILHGT HNYLVVNHPE 120
  121 MLKLYIRISD SFKYISKSSL ERPTSLINNL QKRKVMADVV IVDEAHLLAT SKDAFKRFYG 180
  181 ENHLKDLMSL CKVLVLVYDD KQALRMGSYW DEGS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 1.20306526252293 bayes_pls_golite062009
catalytic activity 0.176212702885001 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.144577483271964 bayes_pls_golite062009
pyrophosphatase activity 0.139313036912271 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.129169762987777 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.127860910307335 bayes_pls_golite062009
hydrolase activity 0.0424527315683166 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [215-279]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNGATLKDFY NEIPPKSRDW YTLKQQFRVA APQNVLNWID QISVAGKIPP IESVLSKGNA  60
   61 DCADD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.762 0.965 nucleus a.4.5 "Winged helix" DNA-binding domain
View Download 0.738 0.965 nucleus a.4.5 "Winged helix" DNA-binding domain
View Download 0.682 0.965 nucleus a.4.5 "Winged helix" DNA-binding domain
View Download 0.680 0.965 nucleus a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.606 0.965 nucleus a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.583 0.965 nucleus a.64.2 Bacteriocin AS-48
View Download 0.582 0.965 nucleus a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.573 0.965 nucleus a.64.1 Saposin
View Download 0.547 0.965 nucleus a.4.5 "Winged helix" DNA-binding domain
View Download 0.499 0.965 nucleus a.65.1 Annexin
View Download 0.493 0.965 nucleus a.4.1 Homeodomain-like
View Download 0.417 0.965 nucleus a.144.2 Ribosomal protein L20
View Download 0.373 0.965 nucleus a.4.1 Homeodomain-like
View Download 0.361 0.965 nucleus a.3.1 Cytochrome c
View Download 0.360 0.965 nucleus a.23.5 Hemolysin expression modulating protein HHA
View Download 0.321 0.965 nucleus a.179.1 Replisome organizer (g39p helicase loader/inhibitor protein)
View Download 0.320 0.965 nucleus a.4.1 Homeodomain-like
View Download 0.300 0.965 nucleus a.5.6 Hypothetical protein MTH1615
View Download 0.289 0.965 nucleus d.15.3 MoaD/ThiS
View Download 0.280 0.965 nucleus a.60.1 SAM/Pointed domain
View Download 0.279 0.965 nucleus a.64.1 Saposin
View Download 0.276 0.965 nucleus a.70.1 N-terminal domain of the delta subunit of the F1F0-ATP synthase
View Download 0.260 0.965 nucleus d.15.2 CAD & PB1 domains
View Download 0.240 0.965 nucleus a.60.5 Barrier-to-autointegration factor, BAF
View Download 0.240 0.965 nucleus g.58.1 Pheromone ER-23
View Download 0.237 0.965 nucleus b.84.2 Rudiment single hybrid motif
View Download 0.224 0.965 nucleus a.58.1 Chemotaxis receptor methyltransferase CheR, N-terminal domain
View Download 0.224 0.965 nucleus a.28.3 Retrovirus capsid protein C-terminal domain
View Download 0.220 0.965 nucleus a.57.1 Protein HNS-dependent expression A; HdeA
View Download 0.210 0.965 nucleus a.39.1 EF-hand
View Download 0.210 0.965 nucleus a.108.1 Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View Download 0.204 0.965 nucleus a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.203 0.965 nucleus a.39.1 EF-hand

Predicted Domain #3
Region A:
Residues: [280-402]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KIKNFDFKIW DDCGAMYEAI KEKDRQYGQC RMLSTYDFPY RLDGKDYYVE CGDNFKVRWD  60
   61 RYTPREVTPW SERCDTIDEV GSVYTIQGFD LNYAGVILGR SIGYDAANDC IKLRPELYDD 120
  121 RAG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.306 0.538 cytoplasm c.3.1 FAD/NAD(P)-binding domain
View Download 0.488 0.071 cytoplasm c.23.1 CheY-like
View Download 0.298 0.022 cytoplasm c.52.1 Restriction endonuclease-like
View Download 0.362 N/A N/A c.25.1 Ferredoxin reductase-like, C-terminal NADP-linked domain
View Download 0.283 N/A N/A c.116.1 alpha/beta knot
View Download 0.274 N/A N/A c.53.1 Resolvase-like
View Download 0.273 N/A N/A d.74.4 Prokaryotic AspRS, insert domain
View Download 0.273 N/A N/A d.93.1 SH2 domain
View Download 0.267 N/A N/A c.48.1 TK C-terminal domain-like
View Download 0.255 N/A N/A c.23.12 Formate/glycerate dehydrogenase catalytic domain-like
View Download 0.238 N/A N/A c.30.1 PreATP-grasp domain
View Download 0.229 N/A N/A b.59.1 XRCC4, N-terminal domain
View Download 0.228 N/A N/A c.25.1 Ferredoxin reductase-like, C-terminal NADP-linked domain
View Download 0.226 N/A N/A c.59.1 MurD-like peptide ligases, peptide-binding domain
View Download 0.222 N/A N/A c.24.1 Methylglyoxal synthase-like
View Download 0.218 N/A N/A c.15.1 BRCT domain
View Download 0.216 N/A N/A b.1.1 Immunoglobulin
View Download 0.212 N/A N/A c.23.6 Cobalamin (vitamin B12)-binding domain
View Download 0.211 N/A N/A b.6.1 Cupredoxins
View Download 0.208 N/A N/A c.23.1 CheY-like
View Download 0.202 N/A N/A d.93.1 SH2 domain

Predicted Domain #4
Region A:
Residues: [403-454]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FTKKKNIHNA EDVKQKIIMN SINVLLTRGV RGLYVYAYDP ELRERLLRPS KK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.493 0.941 nucleus a.4.1 Homeodomain-like
View Download 0.397 0.941 nucleus d.80.1 Tautomerase/MIF
View Download 0.519 0.941 nucleus d.68.3 SirA-like
View Download 0.446 0.941 nucleus c.78.2 Aspartate/glutamate racemase
View Download 0.391 0.941 nucleus g.7.1 Snake toxin-like
View Download 0.346 0.941 nucleus d.15.7 Immunoglobulin-binding domains
View Download 0.322 0.941 nucleus d.58.1 4Fe-4S ferredoxins
View Download 0.266 0.941 nucleus a.153.1 Nuclear receptor coactivator interlocking domain
View Download 0.228 0.941 nucleus a.4.5 "Winged helix" DNA-binding domain
View Download 0.221 0.941 nucleus d.54.1 Enolase N-terminal domain-like
View Download 0.208 0.941 nucleus a.4.1 Homeodomain-like


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle