YRC Public Data Repository - Protein Structure Prediction

Protein:	YPL245W
Organism:	Saccharomyces cerevisiae
Length:	454 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YPL245W.

Description	E-value	Query Range	Subject Range
YP245_YEAST - Uncharacterized protein YPL245W OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YPL245W ... gi\|207340752 - gi\|207340752\|gb\|EDZ69002.1\| YPL245Wp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|190407720 - gi\|190407720\|gb\|EDV10985.1\| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a] YPL245W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to bo...	0.0	[1..454]	[1..454]
gi\|238833802, gi... - gi\|238853584\|ref\|ZP_04643954.1\| AbiBL11 [Lactobacillus gasseri 202-4], gi\|238833802\|gb\|EEQ26069.1\| A... gi\|116629978, gi... - gi\|23003678\|ref\|ZP_00047332.1\| hypothetical protein Lgas_03001717 [Lactobacillus gasseri ATCC 33323]... gi\|23003678 - gi\|23003678\|ref\|ZP_00047332.1\| COG3410: Uncharacterized conserved protein [Lactobacillus gasseri] gi\|226819985 - gi\|226819985\|ref\|ZP_03809104.1\| hypothetical protein LgasM_04989 [Lactobacillus gasseri MV-22]	0.0	[27..454]	[1..403]
gi\|28377274, gi\|... - gi\|28377274\|ref\|NP_784166.1\| hypothetical protein lp_0359 [Lactobacillus plantarum WCFS1], gi\|282701... gi\|254555490, gi... - gi\|254555490\|ref\|YP_003061907.1\| hypothetical protein JDM1_0321 [Lactobacillus plantarum JDM1], gi\|2...	0.0	[25..451]	[3..398]
gi\|7480499 - pir\|\|T29128 probable ATP/GTP binding protein - Streptomyces coelicolor gi\|3451451, gi\|2... - gi\|3451451\|emb\|CAA20510.1\| putative ATP/GTP binding protein [Streptomyces coelicolor A3(2)], gi\|2122...	0.0	[4..451]	[201..617]
gi\|29828357, gi\|... - gi\|29828357\|ref\|NP_822991.1\| ATP/GTP-binding protein [Streptomyces avermitilis MA-4680], gi\|29605460...	0.0	[4..452]	[201..618]
gi\|23023875, gi\|... - gi\|23023875\|ref\|ZP_00063104.1\| COG3410: Uncharacterized conserved protein [Leuconostoc mesenteroides...	0.0	[40..453]	[14..386]
gi\|10644758 - gi\|10644758\|gb\|AAG21387.1\|AF302051_1 AbiBL11 [Bacillus licheniformis]	0.0	[34..438]	[153..528]
gi\|25394369 - pir\|\|B90289 conserved hypothetical protein [imported] - Sulfolobus solfataricus gi\|13814539, gi\|... - gi\|15898174\|ref\|NP_342779.1\| hypothetical protein SSO1331 [Sulfolobus solfataricus P2], gi\|13814539\|...	2.0E-93	[37..453]	[201..602]

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Predicted Domain #1

Region A:
Residues: [1-214]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHGPTSKAIS RNVRSVKRPR RAPRPVVSTQ AMNKLSNVTL SAEQEKLRER VLSFMRSNLS  60
   61 QYKSDWKHPA MFVIQGDAGT GKSVILNSLF NEIQKLSQFS PSSEDILHGT HNYLVVNHPE 120
  121 MLKLYIRISD SFKYISKSSL ERPTSLINNL QKRKVMADVV IVDEAHLLAT SKDAFKRFYG 180
  181 ENHLKDLMSL CKVLVLVYDD KQALRMGSYW DEGS

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
binding	1.20306526252293	bayes_pls_golite062009
catalytic activity	0.176212702885001	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.144577483271964	bayes_pls_golite062009
pyrophosphatase activity	0.139313036912271	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.129169762987777	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.127860910307335	bayes_pls_golite062009
hydrolase activity	0.0424527315683166	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [215-279]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNGATLKDFY NEIPPKSRDW YTLKQQFRVA APQNVLNWID QISVAGKIPP IESVLSKGNA  60
   61 DCADD

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.762	0.965	nucleus	a.4.5	"Winged helix" DNA-binding domain

Predicted Domain #3

Region A:
Residues: [280-402]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KIKNFDFKIW DDCGAMYEAI KEKDRQYGQC RMLSTYDFPY RLDGKDYYVE CGDNFKVRWD  60
   61 RYTPREVTPW SERCDTIDEV GSVYTIQGFD LNYAGVILGR SIGYDAANDC IKLRPELYDD 120
  121 RAG

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [403-454]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FTKKKNIHNA EDVKQKIIMN SINVLLTRGV RGLYVYAYDP ELRERLLRPS KK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.493	0.941	nucleus	a.4.1	Homeodomain-like

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: