| Protein: | REV3 |
| Organism: | Saccharomyces cerevisiae |
| Length: | 1504 amino acids |
| Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for REV3.
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [1..1504] | [1..1504] |
|
|
0.0 | [222..1502] | [161..1408] |
|
|
0.0 | [405..1497] | [24..1098] |
|
|
0.0 | [403..1497] | [25..1100] |
|
|
0.0 | [407..1504] | [44..1103] |
|
Region A: Residues: [1-496] |
1 11 21 31 41 51
| | | | | |
1 MSRESNDTIQ SDTVRSSSKS DYFRIQLNNQ DYYMSKPTFL DPSHGESLPL NQFSQVPNIR 60
61 VFGALPTGHQ VLCHVHGILP YMFIKYDGQI TDTSTLRHQR CAQVHKTLEV KIRASFKRKK 120
121 DDKHDLAGDK LGNLNFVADV SVVKGIPFYG YHVGWNLFYK ISLLNPSCLS RISELIRDGK 180
181 IFGKKFEIYE SHIPYLLQWT ADFNLFGCSW INVDRCYFRS PVLNSILDID KLTINDDLQL 240
241 LLDRFCDFKC NVLSRRDFPR VGNGLIEIDI LPQFIKNREK LQHRDIHHDF LEKLGDISDI 300
301 PVKPYVSSAR DMINELTMQR EELSLKEYKE PPETKRHVSG HQWQSSGEFE AFYKKAQHKT 360
361 STFDGQIPNF ENFIDKNQKF SAINTPYEAL PQLWPRLPQI EINNNSMQDK KNDDQVNASF 420
421 TEYEICGVDN ENEGVKGSNI KSRSYSWLPE SIASPKDSTI LLDHQTKYHN TINFSMDCAM 480
481 TQNMASKRKL RSSVSA
|
| Detection Method: |  |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
| Term | Confidence | Notes |
| DNA polymerase activity | 6.51831885728039 | bayes_pls_golite062009 |
| DNA-directed DNA polymerase activity | 6.42945369067649 | bayes_pls_golite062009 |
| nucleotidyltransferase activity | 3.42625326049348 | bayes_pls_golite062009 |
| exonuclease activity | 2.42385802668375 | bayes_pls_golite062009 |
| nuclease activity | 2.3585392577109 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 1.87077985717699 | bayes_pls_golite062009 |
| hydrolase activity | 1.69425891399878 | bayes_pls_golite062009 |
| deoxyribonuclease activity | 1.57163645477983 | bayes_pls_golite062009 |
| exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters | 1.56072850970382 | bayes_pls_golite062009 |
| transferase activity | 1.50643818103939 | bayes_pls_golite062009 |
| hydrolase activity, acting on ester bonds | 1.40357236263993 | bayes_pls_golite062009 |
| catalytic activity | 1.16880796007849 | bayes_pls_golite062009 |
| ribonuclease activity | 0.960049819952372 | bayes_pls_golite062009 |
| endonuclease activity | 0.534786841661065 | bayes_pls_golite062009 |
| exodeoxyribonuclease activity, producing 5'-phosphomonoesters | 0.465219885210723 | bayes_pls_golite062009 |
| exodeoxyribonuclease activity | 0.458511384089789 | bayes_pls_golite062009 |
| binding | 0.398039259461279 | bayes_pls_golite062009 |
| 3'-5' exonuclease activity | 0.302353039191978 | bayes_pls_golite062009 |
| endodeoxyribonuclease activity | 0.267413339207743 | bayes_pls_golite062009 |
| nucleic acid binding | 0.139161264902915 | bayes_pls_golite062009 |
|
Region A: Residues: [497-561] |
1 11 21 31 41 51
| | | | | |
1 NKTSLLSRKR KKVMAAGLRY GKRAFVYGEP PFGYQDILNK LEDEGFPKID YKDPFFSNPV 60
61 DLENK
|
|
Region B: Residues: [649-941] |
1 11 21 31 41 51
| | | | | |
1 ASDVSGKQKR KKSSVHDSLT HLTLEIHANT RSDKIPDPAI DEVSMIIWCL EEETFPLDLD 60
61 IAYEGIMIVH KASEDSTFPT KIQHCINEIP VMFYESEFEM FEALTDLVLL LDPDILSGFE 120
121 IHNFSWGYII ERCQKIHQFD IVRELARVKC QIKTKLSDTW GYAHSSGIMI TGRHMINIWR 180
181 ALRSDVNLTQ YTIESAAFNI LHKRLPHFSF ESLTNMWNAK KSTTELKTVL NYWLSRAQIN 240
241 IQLLRKQDYI ARNIEQARLI GIDFHSVYYR GSQFKVESFL IRICKSESFI LLS
|
| Detection Method: | |
| Confidence: | 1346.9897 |
| Match: | 1tgoA_ |
| Description: | Exonuclease domain of family B (archaeal and phage) DNA polymerases; T4-like DNA polymerase |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| DNA-directed DNA polymerase activity | 10.1611665880073 | bayes_pls_golite062009 |
| DNA polymerase activity | 10.1200278407684 | bayes_pls_golite062009 |
| nucleotidyltransferase activity | 7.01618726201671 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 4.79232184185512 | bayes_pls_golite062009 |
| transferase activity | 4.02382113115178 | bayes_pls_golite062009 |
| exonuclease activity | 1.42205333874102 | bayes_pls_golite062009 |
| ribonuclease activity | 1.41033617404868 | bayes_pls_golite062009 |
| catalytic activity | 1.04899053677564 | bayes_pls_golite062009 |
| endonuclease activity | 0.935348031740788 | bayes_pls_golite062009 |
| RNA polymerase activity | 0.85118236015516 | bayes_pls_golite062009 |
| DNA-directed RNA polymerase activity | 0.85118236015516 | bayes_pls_golite062009 |
| binding | 0.808919229163124 | bayes_pls_golite062009 |
| DNA binding | 0.70170581479383 | bayes_pls_golite062009 |
| DNA primase activity | 0.63285588131467 | bayes_pls_golite062009 |
| nucleic acid binding | 0.629777822022422 | bayes_pls_golite062009 |
| endodeoxyribonuclease activity | 0.48776342704945 | bayes_pls_golite062009 |
| damaged DNA binding | 0.39441061793492 | bayes_pls_golite062009 |
| exoribonuclease activity | 0.14466215642144 | bayes_pls_golite062009 |
| protein binding | 0.101829155879905 | bayes_pls_golite062009 |
| 3'-5' exonuclease activity | 0.0700154911930899 | bayes_pls_golite062009 |
| exoribonuclease activity, producing 5'-phosphomonoesters | 0.0662718964590603 | bayes_pls_golite062009 |
| nuclease activity | 0.0574785418962505 | bayes_pls_golite062009 |
|
Region A: Residues: [562-648] |
1 11 21 31 41 51
| | | | | |
1 PYAYAGKRFE ISSTHVSTRI PVQFGGETVS VYNKPTFDMF SSWKYALKPP TYDAVQKWYN 60
61 KVPSMGNKKT ESQISMHTPH SKFLYKF
|
|
Region B: Residues: [942-956] |
1 11 21 31 41 51
| | | | | |
1 PGKKDVRKQK ALECV
|
|
Region C: Residues: [978-1117] |
1 11 21 31 41 51
| | | | | |
1 SLYPSIMIGY NYCYSTMIGR VREINLTENN LGVSKFSLPR NILALLKNDV TIAPNGVVYA 60
61 KTSVRKSTLS KMLTDILDVR VMIKKTMNEI GDDNTTLKRL LNNKQLALKL LANVTYGYTS 120
121 ASFSGRMPCS DLADSIVQTG
|
| Detection Method: | |
| Confidence: | 1346.9897 |
| Match: | 1tgoA_ |
| Description: | Exonuclease domain of family B (archaeal and phage) DNA polymerases; T4-like DNA polymerase |
| Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| binding | 0.874307362804644 | bayes_pls_golite062009 |
| catalytic activity | 0.223774911842048 | bayes_pls_golite062009 |
|
Region A: Residues: [957-977] |
1 11 21 31 41 51
| | | | | |
1 PLVMEPESAF YKSPLIVLDF Q
|
|
Region B: Residues: [1118-1214] |
1 11 21 31 41 51
| | | | | |
1 RETLEKAIDI IEKDETWNAK VVYGDTDSLF VYLPGKTAIE AFSIGHAMAE RVTQNNPKPI 60
61 FLKFEKVYHP SILISKKRYV GFSYESPSQT LPIFDAK
|
| Detection Method: | |
| Confidence: | 1346.9897 |
| Match: | 1tgoA_ |
| Description: | Exonuclease domain of family B (archaeal and phage) DNA polymerases; T4-like DNA polymerase |
| Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [1215-1394] |
1 11 21 31 41 51
| | | | | |
1 GIETVRRDGI PAQQKIIEKC IRLLFQTKDL SKIKKYLQNE FFKIQIGKVS AQDFCFAKEV 60
61 KLGAYKSEKT APAGAVVVKR RINEDHRAEP QYKERIPYLV VKGKQGQLLR ERCVSPEEFL 120
121 EGENLELDSE YYINKILIPP LDRLFNLIGI NVGNWAQEIV KSKRASTTTT KVENITRVGT 180
181
|
| Detection Method: | |
| Confidence: | 1346.9897 |
| Match: | 1tgoA_ |
| Description: | Exonuclease domain of family B (archaeal and phage) DNA polymerases; T4-like DNA polymerase |
| Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [1395-1504] |
1 11 21 31 41 51
| | | | | |
1 SATCCNCGEE LTKICSLQLC DDCLEKRSTT TLSFLIKKLK RQKEYQTLKT VCRTCSYRYT 60
61 SDAGIENDHI ASKCNSYDCP VFYSRVKAER YLRDNQSVQR EEALISLNDW
|
| Detection Method: | |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
| MCM Score |
GO Score |
GO Term |
SCOP Match |
SCOP Description | ||
| View | Download | 0.570 | 0.225 | mutagenesis | a.26.1 | 4-helical cytokines |
| View | Download | 0.410 | 0.196 | mutagenesis | d.19.1 | MHC antigen-recognition domain |
| View | Download | 0.381 | 0.017 | mutagenesis | a.24.9 | alpha-catenin/vinculin |
| View | Download | 0.524 | 0.005 | mutagenesis | a.72.1 | Functional domain of the splicing factor Prp18 |
| View | Download | 0.418 | N/A | N/A | a.26.1 | 4-helical cytokines |
| View | Download | 0.372 | N/A | N/A | a.25.1 | Ferritin-like |
| View | Download | 0.359 | N/A | N/A | d.19.1 | MHC antigen-recognition domain |
| View | Download | 0.340 | N/A | N/A | a.7.2 | Enzyme IIa from lactose specific PTS, IIa-lac |
| View | Download | 0.335 | N/A | N/A | f.14.1 | Voltage-gated potassium channels |
| View | Download | 0.331 | N/A | N/A | f.14.1 | Voltage-gated potassium channels |
| View | Download | 0.327 | N/A | N/A | d.58.20 | NAD-binding domain of HMG-CoA reductase |
| View | Download | 0.319 | N/A | N/A | f.14.1 | Voltage-gated potassium channels |
| View | Download | 0.310 | N/A | N/A | f.17.2 | Cytochrome c oxidase subunit II-like, transmembrane region |
| View | Download | 0.306 | N/A | N/A | a.177.1 | Sigma2 domain of RNA polymerase sigma factors |
| View | Download | 0.299 | N/A | N/A | f.14.1 | Voltage-gated potassium channels |
| View | Download | 0.296 | N/A | N/A | a.29.3 | Acyl-CoA dehydrogenase C-terminal domain-like |
| View | Download | 0.294 | N/A | N/A | d.52.7 | Ribosome-binding factor A, RbfA |
| View | Download | 0.290 | N/A | N/A | a.45.1 | Glutathione S-transferase (GST), C-terminal domain |
| View | Download | 0.286 | N/A | N/A | a.47.2 | t-snare proteins |
| View | Download | 0.268 | N/A | N/A | d.58.49 | YajQ-like |
| View | Download | 0.267 | N/A | N/A | f.36.1 | Neurotransmitter-gated ion-channel pransmembrane pore |
| View | Download | 0.262 | N/A | N/A | d.52.4 | YhbC-like, N-terminal domain |
| View | Download | 0.256 | N/A | N/A | d.129.2 | Phosphoglucomutase, C-terminal domain |
| View | Download | 0.251 | N/A | N/A | a.24.16 | Nucleotidyltransferase substrate binding subunit/domain |
| View | Download | 0.250 | N/A | N/A | d.58.7 | RNA-binding domain, RBD |
| View | Download | 0.239 | N/A | N/A | d.19.1 | MHC antigen-recognition domain |
| View | Download | 0.231 | N/A | N/A | a.24.3 | Cytochromes |
| View | Download | 0.229 | N/A | N/A | a.24.10 | Histidine-containing phosphotransfer domain, HPT domain |
| View | Download | 0.226 | N/A | N/A | d.232.1 | Mago nashi protein |
| View | Download | 0.223 | N/A | N/A | b.40.4 | Nucleic acid-binding proteins |
| View | Download | 0.216 | N/A | N/A | d.227.1 | OsmC-like |
| View | Download | 0.214 | N/A | N/A | a.133.1 | Phospholipase A2, PLA2 |
| View | Download | 0.208 | N/A | N/A | a.2.8 | Eukaryotic DNA topoisomerase I, dispensable insert domain |
| View | Download | 0.208 | N/A | N/A | d.227.1 | OsmC-like |
| View | Download | 0.206 | N/A | N/A | d.16.1 | FAD-linked reductases, C-terminal domain |
| View | Download | 0.202 | N/A | N/A | a.76.1 | Iron-dependent represor protein, dimerization domain |
| View | Download | 0.202 | N/A | N/A | a.2.7 | tRNA-binding arm |
