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View Structure Prediction Details

Protein: UME1
Organism: Saccharomyces cerevisiae
Length: 460 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for UME1.

Description E-value Query
Range
Subject
Range
RBBP4 - retinoblastoma binding protein 4
RBBP4_MOUSE - Histone-binding protein RBBP4 OS=Mus musculus GN=Rbbp4 PE=1 SV=5
ENSCJAT00000001857 - null
gi|73949954, gi|... - gi|73949954|ref|XP_864445.1| PREDICTED: similar to retinoblastoma binding protein 4 isoform 8 [Canis...
gi|123998073, gi... - gi|60655333|gb|AAX32230.1| retinoblastoma binding protein 4 [synthetic construct], gi|60655331|gb|AA...
ENSPTRT00000000953 - null
RBBP4_BOVIN - Histone-binding protein RBBP4 OS=Bos taurus GN=RBBP4 PE=1 SV=3
gi|157817007, gi... - gi|197246471|gb|AAI68994.1| Rbbp4 protein [Rattus norvegicus], gi|157817007|ref|NP_001101382.1| reti...
gi|449692 - gi|449692|prf||1919423A retinoblastoma-binding protein
tr|M3WS50|M3WS50... - RB binding protein 4, chromatin remodeling factor OS=Felis catus GN=RBBP4 PE=4 SV=1
gi|126330240 - gi|126330240|ref|XP_001366492.1| PREDICTED: similar to retinoblastoma binding protein [Monodelphis d...
gi|109001615, gi... - gi|109001618|ref|XP_001104493.1| PREDICTED: retinoblastoma binding protein 4 isoform 7 [Macaca mulat...
0.0 [2..444] [6..405]
RBBP4_CHICK - Histone-binding protein RBBP4 OS=Gallus gallus GN=RBBP4 PE=1 SV=3
0.0 [2..444] [6..405]
gi|182890274, gi... - gi|28277505|gb|AAH45315.1| Retinoblastoma binding protein 4 [Danio rerio], gi|182890274|gb|AAI65845....
0.0 [2..444] [6..405]
RBP4A_XENLA - Histone-binding protein RBBP4-A OS=Xenopus laevis GN=rbbp4-a PE=1 SV=3
0.0 [2..444] [6..405]
gi|195328823, gi... - gi|195328823|ref|XP_002031111.1| GM24205 [Drosophila sechellia], gi|194120054|gb|EDW42097.1| GM24205...
gi|195570742, gi... - gi|195570742|ref|XP_002103363.1| GD18995 [Drosophila simulans], gi|194199290|gb|EDX12866.1| GD18995 ...
Caf1-PA - The gene Chromatin assembly factor 1 subunit is referred to in FlyBase by the symbol Dmel\Caf1 (CG42...
gi|220955822, gi... - gi|220955822|gb|ACL90454.1| Caf1-PA [synthetic construct], gi|220946090|gb|ACL85588.1| Caf1-PA [synt...
1.0E-99 [3..444] [11..409]
gi|186464325, gi... - gi|23128981|ref|ZP_00110817.1| COG2319: FOG: WD40 repeat [Nostoc punctiforme PCC 73102], gi|18668187...
4.0E-98 [42..460] [1167..1638]

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Predicted Domain #1
Region A:
Residues: [1-64]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTLDIAEDN KIKNEEFKIW KKSIPSLYQH ISSLKPIFGS GVDESPSTLR SIVFTNDSSC  60
   61 NKSK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [65-460]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVLSVPLLYS QGSEIFEVDC IVPLGLHYKK PESISEPLVQ PDYTMESQKV EQTVLIPKWE  60
   61 FKGETIAKMI YVDNSEINVK VIALSTNGSL AWFREGVKSP VYTMMEPSTS LSSASSGNQN 120
  121 KPCVDFAISN DSKTLTVTKE KHLDNENATI KLIDNSGKIG EVLRTIPVPG IKNIQEIKFL 180
  181 NNQIFATCSD DGIIRFWGNE IGKKPLWILN DSLDGKTTCF AASPFVDTLF MTGTSGGALK 240
  241 VWDIRAVIAL GDADAELNIN QGHNKVNELF KVHHFYSEQV SKIEFSSISP MEVVTIGGLG 300
  301 NVYHWNFEPV FAIYNEIHED FQGIISDELE AESMAFYHTE GCRREIGENN KVNTVAYHKY 360
  361 IEDLVATVDS DGLLTVYKPF TGKVLDGSRE VGAAKS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 61.30103
Match: 1gg2B_
Description: beta1-subunit of the signal-transducing G protein heterotrimer
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.42570478946173 bayes_pls_golite062009
transcription regulator activity 2.3610959773142 bayes_pls_golite062009
nucleic acid binding 2.30918780727915 bayes_pls_golite062009
protein binding 2.26925404328312 bayes_pls_golite062009
DNA binding 1.71685536470455 bayes_pls_golite062009
transcription activator activity 1.23969853550045 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.21305848427711 bayes_pls_golite062009
cytoskeletal protein binding 1.19593750149343 bayes_pls_golite062009
transcription factor activity 1.08768505897883 bayes_pls_golite062009
0.88172763425403 bayes_pls_golite062009
transporter activity 0.692270256454453 bayes_pls_golite062009
histone binding 0.685319917508843 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.676924760416604 bayes_pls_golite062009
transcription repressor activity 0.658573452658359 bayes_pls_golite062009
DNA-dependent ATPase activity 0.612501046529002 bayes_pls_golite062009
actin binding 0.529861581509437 bayes_pls_golite062009
transcription factor binding 0.489473003915035 bayes_pls_golite062009
histone methyltransferase activity 0.311523647180993 bayes_pls_golite062009
transcription cofactor activity 0.30761651528651 bayes_pls_golite062009
structural molecule activity 0.254012051644049 bayes_pls_golite062009
protein kinase activity 0.229242350006544 bayes_pls_golite062009
transcription corepressor activity 0.182612389752591 bayes_pls_golite062009
chromatin binding 0.151977098745772 bayes_pls_golite062009
substrate-specific transporter activity 0.121183207943714 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.00585398682921312 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle