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View Structure Prediction Details

Protein: RAT1
Organism: Saccharomyces cerevisiae
Length: 1006 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RAT1.

Description E-value Query
Range
Subject
Range
XRN2_SCHPO - 5'-3' exoribonuclease 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=dhp1 PE=1 SV=1
dhp1 - 5'-3' exoribonuclease Dhp1
0.0 [1..993] [1..981]
gi|20146498, gi|... - gi|50902124|ref|XP_463495.1| putative 5-3 exoribonuclease [Oryza sativa (japonica cultivar-group)], ...
0.0 [1..1000] [1..986]
gi|9369381, gi|2... - gi|9369381|gb|AAF87130.1|AC006434_26 F10A5.15 [Arabidopsis thaliana], pir||D96786 protein F10A5.15 [...
0.0 [1..998] [1..962]
RAT1 - Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snR...
XRN2_YEAST - 5'-3' exoribonuclease 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RAT1 PE=1 SV=3
0.0 [1..1006] [1..1006]
XRN2_NEUCR - 5'-3' exoribonuclease 2 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257...
XRN2_NEUCR - 5'-3' exoribonuclease 2 OS=Neurospora crassa GN=rat-1 PE=3 SV=3
0.0 [1..895] [1..888]

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Predicted Domain #1
Region A:
Residues: [1-271]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGVPSFFRWL SRKYPKIISP VLEEQPQIVD GVILPLDYSA SNPNGELDNL YLDMNGIVHP  60
   61 CSHPENKPPP ETEDEMLLAV FEYTNRVLNM ARPRKVLVMA VDGVAPRAKM NQQRARRFRS 120
  121 ARDAQIENEA REEIMRQREE VGEIIDDAVR NKKTWDSNAI TPGTPFMDKL AAALRYWTAF 180
  181 KLATDPGWKN LQVIISDATV PGEGEHKIMN FIRSQRADPE YNPNTTHCIY GLDADLIFLG 240
  241 LATHEPHFKI LREDVFAQDN RKRNNLKDTI N

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 188.481486
Match: PF03159
Description: XRN 5'-3' exonuclease N-terminus

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [272-678]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTEEEKQFLQ KQNSEQPFLW LHINVLREYL SAELWVPGLP FTFDLERAID DWVFMCFFCG  60
   61 NDFLPHLPCL DVRENSIDIL LDIWKVVLPK LKTYMTCDGV LNLPSVETLL QHLGSREGDI 120
  121 FKTRHIQEAR KKEAFERRKA QKNMSKGQDR HPTVATEQLQ MYDTQGNLAK GSWNLTTSDM 180
  181 VRLKKELMLA NEGNEEAIAK VKQQSDKNNE LMKDISKEEI DDAVSKANKT NFNLAEVMKQ 240
  241 KIINKKHRLE KDNEEEEIAK DSKKVKTEKA ESECDLDAEI KDEIVADVND RENSETTEVS 300
  301 RDSPVHSTVN VSEGPKNGVF DTDEFVKLFE PGYHERYYTA KFHVTPQDIE QLRKDMVKCY 360
  361 IEGVAWVLMY YYQGCASWNW FYPYHYAPLA TDFHGFSHLE IKFEEGT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.520 d.50.2 Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain
View Download 0.489 c.55.4 Translational machinery components
View Download 0.472 b.40.2 Bacterial enterotoxins
View Download 0.469 d.15.1 Ubiquitin-like
View Download 0.435 d.93.1 SH2 domain

Predicted Domain #3
Region A:
Residues: [679-789]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PFLPYEQLMS VLPAASGHAL PKIFRSLMSE PDSEIIDFYP EEFPIDMNGK KMSWQGIALL  60
   61 PFIDQDRLLT AVRAQYPLLS DAERARNIRG EPVLLISNKN ANYERFSKKL Y

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.402 0.673 RNA processing c.52.2 tRNA splicing endonuclease, C-terminal domain
View Download 0.292 0.002 RNA processing a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.265 0.000 RNA processing d.65.1 Hedgehog/DD-pepidase
View Download 0.331 0.000 RNA processing d.199.1 DNA-binding C-terminal domain of the transcription factor MotA
View Download 0.319 N/A N/A c.58.1 Aminoacid dehydrogenase-like, N-terminal domain
View Download 0.252 N/A N/A a.39.1 EF-hand
View Download 0.243 N/A N/A a.74.1 Cyclin-like

Predicted Domain #4
Region A:
Residues: [790-880]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKENNNNNVV VKFQHFKSGL SGIVSKDVEG FELNGKIVCP IQGGSLPNLS TTLILKMSYR  60
   61 LIPLPSRNKS IILNGFIPSE PVLTAYDLDS I

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.469 d.15.1 Ubiquitin-like
View Download 0.435 d.93.1 SH2 domain
View Download 0.472 b.40.2 Bacterial enterotoxins
View Download 0.489 c.55.4 Translational machinery components
View Download 0.520 d.50.2 Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain
View Download 0.431 d.54.1 Enolase N-terminal domain-like
View Download 0.394 b.40.4 Nucleic acid-binding proteins
View Download 0.391 b.2.2 Carbohydrate-binding domain
View Download 0.354 d.52.3 Prokaryotic type KH domain (KH-domain type II)
View Download 0.277 b.55.1 PH domain-like
View Download 0.249 b.61.4 Quinohemoprotein amine dehydrogenase A chain, domain 3
View Download 0.244 b.61.3 D-aminopeptidase, middle and C-terminal domains
View Download 0.231 a.181.1 Antibiotic binding domain of TipA-like multidrug resistance regulators
View Download 0.231 b.1.1 Immunoglobulin
View Download 0.213 b.89.1 Cyanovirin-N
View Download 0.203 d.54.1 Enolase N-terminal domain-like

Predicted Domain #5
Region A:
Residues: [881-1006]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYKYNNQNYS RRWNFGNDLK QNIVPVGPKG ITQYKPRTGG YRAFFYFAEL SRNNVQPAHN  60
   61 YGRNSYNSQP GFNNSRYDGG NNNYRQNSNY RNNNYSGNRN SGQYSGNSYS RNNKQSRYDN 120
  121 SRANRR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.243 0.070 nucleus a.74.1 Cyclin-like


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