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View Structure Prediction Details

Protein: PHO80
Organism: Saccharomyces cerevisiae
Length: 293 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PHO80.

Description E-value Query
Range
Subject
Range
gi|151945629 - gi|151945629|gb|EDN63870.1| Pho80p cyclin [Saccharomyces cerevisiae YJM789]
PHO80_YEAST - PHO85 cyclin PHO80 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PHO80 PE=1 SV=3
PHO80 - Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and...
gi|190407341 - gi|190407341|gb|EDV10608.1| Pho80p cyclin [Saccharomyces cerevisiae RM11-1a]
1.0E-95 [1..293] [1..293]
CCNA1 - cyclin A1
1.0E-42 [2..202] [163..377]
CCU22_ARATH - Cyclin-U2-2 OS=Arabidopsis thaliana GN=CYCU2-2 PE=1 SV=1
4.0E-42 [28..211] [25..217]
gi|25493992, gi|... - gi|2982283|gb|AAC32127.1| PREG-like protein [Picea mariana], pir||T52062 PREG-like protein [imported...
2.0E-40 [28..188] [66..222]

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Predicted Domain #1
Region A:
Residues: [1-209]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MESTSGERSE NIHEDQGIPK VILPADFNKC SRTDLVVLIS RMLVSLIAIN ENSATKKSDD  60
   61 QITLTRYHSK IPPNISIFNY FIRLTKFSSL EHCVLMTSLY YIDLLQTVYP DFTLNSLTAH 120
  121 RFLLTATTVA TKGLCDSFST NAHYAKVGGV RCHELNILEN DFLKRVNYRI IPRDHNITLC 180
  181 SIEQKQKKFV IDKNALGSLD LDSYSYVNR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 32.522879
Match: 1vin__
Description: Cyclin A
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cyclin-dependent protein kinase regulator activity 6.12919068656167 bayes_pls_golite062009
cyclin-dependent protein kinase activity 3.81462270101479 bayes_pls_golite062009
protein kinase regulator activity 2.90083336559452 bayes_pls_golite062009
kinase regulator activity 2.84789294954357 bayes_pls_golite062009
transcription regulator activity 2.795846725429 bayes_pls_golite062009
binding 2.4204867358489 bayes_pls_golite062009
nucleic acid binding 2.04886889839181 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.00665312545368 bayes_pls_golite062009
DNA binding 1.94297811210385 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.86347643875964 bayes_pls_golite062009
enzyme regulator activity 1.65951279073909 bayes_pls_golite062009
protein binding 1.47106731485576 bayes_pls_golite062009
transcription repressor activity 1.42956126861466 bayes_pls_golite062009
transcription factor activity 1.21921365719206 bayes_pls_golite062009
protein kinase activity 0.957590284872001 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.806564872314381 bayes_pls_golite062009
kinase activity 0.79567569649664 bayes_pls_golite062009
transcription factor binding 0.749278791251235 bayes_pls_golite062009
protein serine/threonine kinase activity 0.567809158275482 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.561985718866596 bayes_pls_golite062009
kinase binding 0.451409627821468 bayes_pls_golite062009
transcription activator activity 0.0696060248241566 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [210-293]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKSGYNVLDK YYRRIVQLVG SFNASPDKSR KVDYVLPPNI DIVSESGSQT TQLKGSSSPN  60
   61 SHSSQKRYSE AKDAHIYNKR SKPD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.311 0.067 regulation of phosphate metabolic process d.93.1 SH2 domain
View Download 0.273 0.003 regulation of phosphate metabolic process a.118.14 FliG
View Download 0.426 0.003 regulation of phosphate metabolic process a.150.1 Anti-sigma factor AsiA
View Download 0.260 0.002 regulation of phosphate metabolic process a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.297 N/A N/A d.237.1 Hypothetical protein YjiA, C-terminal domain
View Download 0.253 N/A N/A a.145.1 Flagellar transcriptional activator FlhD
View Download 0.237 N/A N/A a.60.11 Hypothetical protein YjbJ
View Download 0.235 N/A N/A a.47.2 t-snare proteins
View Download 0.222 N/A N/A d.24.1 Pili subunits
View Download 0.210 N/A N/A a.4.5 "Winged helix" DNA-binding domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle