| Protein: | RAD50 |
| Organism: | Saccharomyces cerevisiae |
| Length: | 1312 amino acids |
| Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RAD50.
| Description | E-value | Query Range |
Subject Range |
|
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0.0 | [74..1203] | [734..1847] |
|
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0.0 | [74..1200] | [737..1847] |
|
|
0.0 | [85..1203] | [743..1845] |
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0.0 | [84..1203] | [739..1845] |
|
|
0.0 | [74..1190] | [733..1833] |
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|
0.0 | [74..1203] | [737..1850] |
|
Region A: Residues: [1-56] |
1 11 21 31 41 51
| | | | | |
1 MSAIYKLSIQ GIRSFDSNDR ETIEFGKPLT LIVGMNGSGK TTIIECLKYA TTGDLP
|
| Detection Method: |  |
| Confidence: | 2.39794 |
| Match: | 1f2tA_ |
| Description: | Rad50 |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [57-404] |
1 11 21 31 41 51
| | | | | |
1 PNSKGGVFIH DPKITGEKDI RAQVKLAFTS ANGLNMIVTR NIQLLMKKTT TTFKTLEGQL 60
61 VAINNSGDRS TLSTRSLELD AQVPLYLGVP KAILEYVIFC HQEDSLWPLS EPSNLKKKFD 120
121 EIFQAMKFTK ALDNLKSIKK DMSVDIKLLK QSVEHLKLDK DRSKAMKLNI HQLQTKIDQY 180
181 NEEVSEIESQ LNEITEKSDK LFKSNQDFQK ILSKVENLKN TKLSISDQVK RLSNSIDILD 240
241 LSKPDLQNLL ANFSKVLMDK NNQLRDLETD ISSLKDRQSS LQSLSNSLIR RQGELEAGKE 300
301 TYEKNRNHLS SLKEAFQHKF QGLSNIENSD MAQVNHEMSQ FKAFISQD
|
| Detection Method: | |
| Confidence: | 78.228787 |
| Match: | 1i84S_ |
| Description: | Heavy meromyosin subfragment |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [405-501] |
1 11 21 31 41 51
| | | | | |
1 LTDTIDQFAK DIQLKETNLS DLIKSITVDS QNLEYNKKDR SKLIHDSEEL AEKLKSFKSL 60
61 STQDSLNHEL ENLKTYKEKL QSWESENIIP KLNQKIE
|
| Detection Method: | |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
| MCM Score |
SCOP Match |
SCOP Description | ||
| View | Download | 0.541 | a.74.1 | Cyclin-like |
| View | Download | 0.597 | a.7.3 | Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain |
| View | Download | 0.700 | a.48.3 | Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 |
| View | Download | 0.684 | a.24.7 | FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) |
| View | Download | 0.543 | a.8.2 | Plasmid maintenance system epsilon/zeta, antidote epsilon subunit |
| View | Download | 0.506 | a.47.2 | t-snare proteins |
| View | Download | 0.480 | a.24.3 | Cytochromes |
| View | Download | 0.439 | f.14.1 | Voltage-gated potassium channels |
| View | Download | 0.426 | i.1.1 | Ribosome and ribosomal fragments |
| View | Download | 0.423 | a.24.13 | Domain of the SRP/SRP receptor G-proteins |
| View | Download | 0.410 | a.23.1 | HSC20 (HSCB), C-terminal oligomerisation domain |
| View | Download | 0.407 | a.7.1 | Spectrin repeat |
| View | Download | 0.403 | i.11.1 | Computational models partly based on NMR data |
| View | Download | 0.373 | a.17.1 | p8-MTCP1 |
| View | Download | 0.373 | a.63.1 | Apolipophorin-III |
| View | Download | 0.366 | a.118.8 | TPR-like |
| View | Download | 0.365 | a.163.1 | Crustacean CHH/MIH/GIH neurohormone |
| View | Download | 0.351 | a.23.4 | Mitochondrial import receptor subunit Tom20 |
| View | Download | 0.325 | a.68.1 | Wiscott-Aldrich syndrome protein, WASP, C-terminal domain |
| View | Download | 0.317 | a.118.1 | ARM repeat |
| View | Download | 0.310 | a.7.1 | Spectrin repeat |
| View | Download | 0.307 | a.46.1 | Methionine synthase domain |
| View | Download | 0.307 | a.24.3 | Cytochromes |
| View | Download | 0.295 | f.1.4 | Bcl-2 inhibitors of programmed cell death |
| View | Download | 0.294 | a.39.3 | Cloroperoxidase |
| View | Download | 0.290 | a.60.6 | DNA polymerase beta, N-terminal domain-like |
| View | Download | 0.287 | a.60.9 | lambda integrase-like, N-terminal domain |
| View | Download | 0.276 | a.74.1 | Cyclin-like |
| View | Download | 0.271 | a.12.1 | Kix domain of CBP (creb binding protein) |
| View | Download | 0.270 | a.24.17 | Group V grass pollen allergen |
| View | Download | 0.270 | a.177.1 | Sigma2 domain of RNA polymerase sigma factors |
| View | Download | 0.265 | a.118.9 | ENTH/VHS domain |
| View | Download | 0.262 | a.74.1 | Cyclin-like |
| View | Download | 0.255 | a.24.17 | Group V grass pollen allergen |
| View | Download | 0.254 | a.7.6 | Ribosomal protein S20 |
| View | Download | 0.245 | a.4.3 | ARID-like |
| View | Download | 0.245 | d.198.1 | Type III secretory system chaperone |
| View | Download | 0.239 | f.32.1 | a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) |
| View | Download | 0.238 | c.95.1 | Thiolase-like |
| View | Download | 0.237 | a.7.8 | GAT domain |
| View | Download | 0.237 | a.2.6 | Effector domain of the protein kinase pkn/prk1 |
| View | Download | 0.234 | a.28.1 | ACP-like |
| View | Download | 0.234 | a.71.1 | Endoplasmic reticulum protein ERP29, C-domain |
| View | Download | 0.231 | d.202.1 | Transcription factor NusA, N-terminal domain |
| View | Download | 0.228 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.228 | c.51.1 | Anticodon-binding domain of Class II aaRS |
| View | Download | 0.225 | c.47.2 | RNA 3'-terminal phosphate cyclase, RPTC, insert domain |
| View | Download | 0.225 | a.24.10 | Histidine-containing phosphotransfer domain, HPT domain |
| View | Download | 0.224 | f.36.1 | Neurotransmitter-gated ion-channel pransmembrane pore |
| View | Download | 0.223 | a.74.1 | Cyclin-like |
| View | Download | 0.223 | a.39.1 | EF-hand |
| View | Download | 0.222 | a.5.3 | N-terminal domain of phosphatidylinositol transfer protein sec14p |
| View | Download | 0.221 | a.39.1 | EF-hand |
| View | Download | 0.220 | a.13.1 | alpha-2-Macroglobulin receptor associated protein (RAP) domain 1 |
| View | Download | 0.218 | a.97.1 | An anticodon-binding domain of class I aminoacyl-tRNA synthetases |
| View | Download | 0.217 | a.29.2 | Bromodomain |
| View | Download | 0.216 | d.232.1 | Mago nashi protein |
| View | Download | 0.216 | a.27.1 | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases |
| View | Download | 0.213 | d.129.2 | Phosphoglucomutase, C-terminal domain |
| View | Download | 0.211 | a.59.1 | PAH2 domain |
| View | Download | 0.210 | a.24.13 | Domain of the SRP/SRP receptor G-proteins |
| View | Download | 0.209 | a.2.7 | tRNA-binding arm |
| View | Download | 0.206 | d.169.1 | C-type lectin-like |
| View | Download | 0.204 | a.75.1 | Ribosomal protein S7 |
| View | Download | 0.202 | d.92.2 | beta-N-acetylhexosaminidase-like domain |
| View | Download | 0.201 | f.17.1 | F1F0 ATP synthase subunit C |
|
Region A: Residues: [502-610] |
1 11 21 31 41 51
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1 EKNNEMIILE NQIEKFQDRI MKTNQQADLY AKLGLIKKSI NTKLDELQKI TEKLQNDSRI 60
61 RQVFPLTQEF QRADLEMDFQ KLFINMQKNI AINNKKMHEL DRRYTNALY
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| Detection Method: | |
| Confidence: | 9.69897 |
| Match: | 2tmaA_ |
| Description: | Tropomyosin |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| transcription regulator activity | 3.33295639088462 | bayes_pls_golite062009 |
| DNA binding | 3.24326474452285 | bayes_pls_golite062009 |
| nucleic acid binding | 3.08466758182729 | bayes_pls_golite062009 |
| binding | 2.82931587763241 | bayes_pls_golite062009 |
| transcription factor activity | 2.60119592373341 | bayes_pls_golite062009 |
| chromatin binding | 1.68308196781423 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 1.49672337781081 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 1.27509072978642 | bayes_pls_golite062009 |
| telomeric DNA binding | 1.18912537020579 | bayes_pls_golite062009 |
| transcription repressor activity | 0.92388271789346 | bayes_pls_golite062009 |
| transcription activator activity | 0.76577083878065 | bayes_pls_golite062009 |
| protein binding | 0.730593483550931 | bayes_pls_golite062009 |
| structure-specific DNA binding | 0.576650348476301 | bayes_pls_golite062009 |
| transcription factor binding | 0.42980456622574 | bayes_pls_golite062009 |
| hydrolase activity | 0.168066467681021 | bayes_pls_golite062009 |
| specific RNA polymerase II transcription factor activity | 0.10360223465653 | bayes_pls_golite062009 |
| histone binding | 0.0391625783266718 | bayes_pls_golite062009 |
| double-stranded DNA binding | 0.0277518020584662 | bayes_pls_golite062009 |
|
Region A: Residues: [611-690] |
1 11 21 31 41 51
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1 NLNTIEKDLQ DNQKSKEKVI QLLSENLPED CTIDEYNDVL EETELSYKTA LENLKMHQTT 60
61 LEFNRKALEI AERDSCCYLC
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| Detection Method: | |
| Confidence: | 9.69897 |
| Match: | 2tmaA_ |
| Description: | Tropomyosin |
| Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [691-752] |
1 11 21 31 41 51
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1 SRKFENESFK SKLLQELKTK TDANFEKTLK DTVQNEKEYL HSLRLLEKHI ITLNSINEKI 60
61 DN
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| Detection Method: | |
| Confidence: | 9.69897 |
| Match: | 2tmaA_ |
| Description: | Tropomyosin |
| Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [753-828] |
1 11 21 31 41 51
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1 SQKCLEKAKE ETKTSKSKLD ELEVDSTKLK DEKELAESEI RPLIEKFTYL EKELKDLENS 60
61 SKTISEELSI YNTSED
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| Detection Method: | |
| Confidence: | 9.69897 |
| Match: | 2tmaA_ |
| Description: | Tropomyosin |
| Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [829-1135] |
1 11 21 31 41 51
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1 GIQTVDELRD QQRKMNDSLR ELRKTISDLQ MEKDEKVREN SRMINLIKEK ELTVSEIESS 60
61 LTQKQNIDDS IRSKRENIND IDSRVKELEA RIISLKNKKD EAQSVLDKVK NERDIQVRNK 120
121 QKTVADINRL IDRFQTIYNE VVDFEAKGFD ELQTTIKELE LNKAQMLELK EQLDLKSNEV 180
181 NEEKRKLADS NNEEKNLKQN LELIELKSQL QHIESEISRL DVQNAEAERD KYQEESLRLR 240
241 TRFEKLSSEN AGKLGEMKQL QNQIDSLTHQ LRTDYKDIEK NYHKEWVELQ TRSFVTDDID 300
301 VYSKALD
|
| Detection Method: | |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
|
Region A: Residues: [1136-1229] |
1 11 21 31 41 51
| | | | | |
1 SAIMKYHGLK MQDINRIIDE LWKRTYSGTD IDTIKIRSDE VSSTVKGKSY NYRVVMYKQD 60
61 VELDMRGRCS AGQKVLASII IRLALSETFG ANCG
|
| Detection Method: | |
| Confidence: | 38.440336 |
| Match: | 1f2tB_ |
| Description: | CRYSTAL STRUCTURE OF ATP-FREE RAD50 ABC-ATPASE |
| Matching Structure (courtesy of the PDB): |
|
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Region A: Residues: [1230-1312] |
1 11 21 31 41 51
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1 VIALDEPTTN LDEENIESLA KSLHNIINMR RHQKNFQLIV ITHDEKFLGH MNAAAFTDHF 60
61 FKVKRDDRQK SQIEWVDINR VTY
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| Detection Method: | |
| Confidence: | 38.440336 |
| Match: | 1f2tB_ |
| Description: | CRYSTAL STRUCTURE OF ATP-FREE RAD50 ABC-ATPASE |
| Matching Structure (courtesy of the PDB): |
|
