YRC Public Data Repository - Protein Structure Prediction

Protein:	ADE12
Organism:	Saccharomyces cerevisiae
Length:	433 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ADE12.

Description	E-value	Query Range	Subject Range
PURA_VIBCH - Adenylosuccinate synthetase OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)... gi\|254846847, gi... - gi\|75828746\|ref\|ZP_00758091.1\| COG0104: Adenylosuccinate synthase [Vibrio cholerae MO10], gi\|2548511... PURA_VIBCM - Adenylosuccinate synthetase OS=Vibrio cholerae serotype O1 (strain M66-2) GN=purA PE=3 SV=1 gi\|121728998, gi... - gi\|75814700\|ref\|ZP_00745258.1\| COG0104: Adenylosuccinate synthase [Vibrio cholerae V52], gi\|12172899... gi\|229507346, gi... - gi\|229507346\|ref\|ZP_04396851.1\| adenylosuccinate synthetase [Vibrio cholerae BX 330286], gi\|22935485... gi\|229509731, gi... - gi\|229509731\|ref\|ZP_04399212.1\| adenylosuccinate synthetase [Vibrio cholerae B33], gi\|229353205\|gb\|E... gi\|229345918, gi... - gi\|229516855\|ref\|ZP_04406301.1\| adenylosuccinate synthetase [Vibrio cholerae RC9], gi\|229345918\|gb\|E... gi\|229606852, gi... - gi\|229606852\|ref\|YP_002877500.1\| adenylosuccinate synthetase [Vibrio cholerae MJ-1236], gi\|229369507... gi\|124118192, gi... - gi\|153223466\|ref\|ZP_01953889.1\| adenylosuccinate synthetase [Vibrio cholerae MAK 757], gi\|124118192\|... gi\|153820226, gi... - gi\|153820226\|ref\|ZP_01972893.1\| adenylosuccinate synthetase [Vibrio cholerae NCTC 8457], gi\|12650922... PURA_VIBCH - Adenylosuccinate synthetase OS=Vibrio cholerae GN=purA PE=3 SV=3	0.0	[3..430]	[5..426]
PURA_YEAS2 - Adenylosuccinate synthetase OS=Saccharomyces cerevisiae (strain JAY291) GN=ADE12 PE=3 SV=1 ADE12 - Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from ino... PURA_YEAST - Adenylosuccinate synthetase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ADE12 PE=1 S...	0.0	[1..433]	[1..433]
PURA_STRP1 - Adenylosuccinate synthetase OS=Streptococcus pyogenes serotype M1 GN=purA PE=3 SV=1 gi\|13621455, gi\|... - gi\|15674367\|ref\|NP_268541.1\| adenylosuccinate synthetase [Streptococcus pyogenes M1 GAS], gi\|1362145... PURA_STRPY - (Q9A1P8) Adenylosuccinate synthetase (EC 6.3.4.4) (IMP--aspartate ligase) (AdSS) (AMPSase)	0.0	[3..427]	[4..420]
PURA_STRP8 - Adenylosuccinate synthetase OS=Streptococcus pyogenes serotype M18 GN=purA PE=3 SV=1 PURA_STRP8 - Adenylosuccinate synthetase OS=Streptococcus pyogenes serotype M18 (strain MGAS8232) GN=purA PE=3 SV... PURA_STRP6 - Adenylosuccinate synthetase OS=Streptococcus pyogenes serotype M6 GN=purA PE=3 SV=1 PURA_STRP6 - Adenylosuccinate synthetase OS=Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394) ...	0.0	[3..427]	[4..420]
gi\|148985359, gi... - gi\|148985359\|ref\|ZP_01818564.1\| adenylosuccinate synthetase [Streptococcus pneumoniae SP3-BS71], gi\|... PURA_STRPN - Adenylosuccinate synthetase OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) GN=... gi\|149023457, gi... - gi\|149023457\|ref\|ZP_01836046.1\| adenylosuccinate synthetase [Streptococcus pneumoniae SP23-BS72], gi... gi\|149010879, gi... - gi\|149010879\|ref\|ZP_01832184.1\| adenylosuccinate synthetase [Streptococcus pneumoniae SP19-BS75], gi... PURA_STRP2 - Adenylosuccinate synthetase OS=Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) GN=purA ... gi\|147761735, gi... - gi\|149006820\|ref\|ZP_01830506.1\| adenylosuccinate synthetase [Streptococcus pneumoniae SP18-BS74], gi... gi\|149004077, gi... - gi\|149004077\|ref\|ZP_01828882.1\| adenylosuccinate synthetase [Streptococcus pneumoniae SP14-BS69], gi... gi\|148998956, gi... - gi\|148998956\|ref\|ZP_01826390.1\| adenylosuccinate synthetase [Streptococcus pneumoniae SP11-BS70], gi... gi\|148995216, gi... - gi\|148995216\|ref\|ZP_01824051.1\| adenylosuccinate synthetase [Streptococcus pneumoniae SP9-BS68], gi\|... gi\|147926201, gi... - gi\|148987737\|ref\|ZP_01819200.1\| adenylosuccinate synthetase [Streptococcus pneumoniae SP6-BS73], gi\|... PURA_STRPJ - Adenylosuccinate synthetase OS=Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1) GN=purA P... gi\|168495077, gi... - gi\|183575063\|gb\|EDT95591.1\| adenylosuccinate synthetase [Streptococcus pneumoniae CDC3059-06], gi\|16... PURA_STRR6 - Adenylosuccinate synthetase OS=Streptococcus pneumoniae (strain ATCC BAA-255 / R6) GN=purA PE=3 SV=1 PURA_STRPN - Adenylosuccinate synthetase OS=Streptococcus pneumoniae GN=purA PE=1 SV=1	0.0	[3..427]	[4..420]
gi\|153839625, gi... - gi\|153839625\|ref\|ZP_01992292.1\| adenylosuccinate synthetase [Vibrio parahaemolyticus AQ3810], gi\|149... PURA_VIBPA - Adenylosuccinate synthetase OS=Vibrio parahaemolyticus GN=purA PE=3 SV=3 PURA_VIBPA - Adenylosuccinate synthetase OS=Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) GN=purA ...	0.0	[3..430]	[5..432]
PURA_PASMU - Adenylosuccinate synthetase OS=Pasteurella multocida GN=purA PE=3 SV=1 PURA_PASMU - Adenylosuccinate synthetase OS=Pasteurella multocida (strain Pm70) GN=purA PE=3 SV=1	0.0	[3..431]	[5..428]
gi\|447739 - gi\|447739\|prf\|\|1915304A nylB upstream ORF	0.0	[2..428]	[33..454]
PURA1_MOUSE - Adenylosuccinate synthetase isozyme 1 OS=Mus musculus GN=Adssl1 PE=1 SV=2	0.0	[2..428]	[33..454]
PURA_ECOUT - Adenylosuccinate synthetase OS=Escherichia coli (strain UTI89 / UPEC) GN=purA PE=3 SV=1 gi\|15834407, gi\|... - gi\|15834407\|ref\|NP_313180.1\| adenylosuccinate synthetase [Escherichia coli O157:H7 str. Sakai], gi\|1... PURA_ECOL5 - Adenylosuccinate synthetase OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=purA PE=3 SV=1 PURA_ECOL6 - Adenylosuccinate synthetase OS=Escherichia coli O6 GN=purA PE=3 SV=2 PURA_SHIDS - Adenylosuccinate synthetase OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=purA PE=3 SV=1 PURA_SHIBS - Adenylosuccinate synthetase OS=Shigella boydii serotype 4 (strain Sb227) GN=purA PE=3 SV=1 gi\|89110897, gi\|... - gi\|89110897\|ref\|AP_004677.1\| adenylosuccinate synthetase [Escherichia coli str. K-12 substr. W3110],... PURA_ECO24 - Adenylosuccinate synthetase OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=purA PE=3 SV=1 PURA_ECOK1 - Adenylosuccinate synthetase OS=Escherichia coli O1:K1 / APEC GN=purA PE=3 SV=1 PURA_ECOHS - Adenylosuccinate synthetase OS=Escherichia coli O9:H4 (strain HS) GN=purA PE=3 SV=1 gi\|124500678, gi... - gi\|124528236\|ref\|ZP_01699560.1\| Adenylosuccinate synthase [Escherichia coli B], gi\|124500678\|gb\|EAY4... gi\|75212274, gi\|... - gi\|75212274\|ref\|ZP_00712314.1\| COG0104: Adenylosuccinate synthase [Escherichia coli B171], gi\|194426... gi\|190904298, gi... - gi\|75231230\|ref\|ZP_00717637.1\| COG0104: Adenylosuccinate synthase [Escherichia coli B7A], gi\|1911656... gi\|192955834, gi... - gi\|75234274\|ref\|ZP_00718662.1\| COG0104: Adenylosuccinate synthase [Escherichia coli E110019], gi\|193... gi\|191170704, gi... - gi\|75242434\|ref\|ZP_00726196.1\| COG0104: Adenylosuccinate synthase [Escherichia coli F11], gi\|7523617... gi\|193066038, gi... - gi\|75255904\|ref\|ZP_00727636.1\| COG0104: Adenylosuccinate synthase [Escherichia coli E22], gi\|1930660... gi\|188493594, gi... - gi\|75515416\|ref\|ZP_00737573.1\| COG0104: Adenylosuccinate synthase [Escherichia coli 53638], gi\|18849... gi\|83585085, gi\|... - gi\|83585085\|ref\|ZP_00923738.1\| COG0104: Adenylosuccinate synthase [Escherichia coli 101-1], gi\|19443... PURA_SHIB3 - Adenylosuccinate synthetase OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=purA PE=3... PURA_ECO55 - Adenylosuccinate synthetase OS=Escherichia coli (strain 55989 / EAEC) GN=purA PE=3 SV=1 PURA_ECO81 - Adenylosuccinate synthetase OS=Escherichia coli O81 (strain ED1a) GN=purA PE=3 SV=1 PURA_ECOLU - Adenylosuccinate synthetase OS=Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) GN=purA PE=3 SV=... PURA_ECO7I - Adenylosuccinate synthetase OS=Escherichia coli O7:K1 (strain IAI39 / ExPEC) GN=purA PE=3 SV=1 sp\|B7UQI6\|PURA_ECO27 - Adenylosuccinate synthetase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=purA PE=3 SV=1 EG10790 - adenylosuccinate synthetase / Adenylosuccinate synthase, purine synthesis gi\|168754747, gi... - gi\|189357871\|gb\|EDU76290.1\| adenylosuccinate synthetase [Escherichia coli O157:H7 str. EC4401], gi\|1... gi\|188014493, gi... - gi\|188014493\|gb\|EDU52615.1\| adenylosuccinate synthetase [Escherichia coli O157:H7 str. EC4113], gi\|1... gi\|189364050, gi... - gi\|189364050\|gb\|EDU82469.1\| adenylosuccinate synthetase [Escherichia coli O157:H7 str. EC4486], gi\|1... gi\|168760418, gi... - gi\|189368933\|gb\|EDU87349.1\| adenylosuccinate synthetase [Escherichia coli O157:H7 str. EC4501], gi\|1... gi\|189001718, gi... - gi\|189001718\|gb\|EDU70704.1\| adenylosuccinate synthetase [Escherichia coli O157:H7 str. EC4076], gi\|1... gi\|187770332, gi... - gi\|187770332\|gb\|EDU34176.1\| adenylosuccinate synthetase [Escherichia coli O157:H7 str. EC4196], gi\|1... PURA_ECOLC - Adenylosuccinate synthetase OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=purA PE=3 ... PURA_ECO5E - Adenylosuccinate synthetase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=purA PE=3 SV=1 gi\|208819801, gi... - gi\|208819801\|ref\|ZP_03260121.1\| adenylosuccinate synthetase [Escherichia coli O157:H7 str. EC4042], ... PURA_ECO27 - Adenylosuccinate synthetase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=purA PE=3 SV=1 PURA_ECOSE - Adenylosuccinate synthetase OS=Escherichia coli (strain SE11) GN=purA PE=3 SV=1 PURA_ESCF3 - Adenylosuccinate synthetase OS=Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73) ... gi\|217320696, gi... - gi\|217324475\|ref\|ZP_03440559.1\| adenylosuccinate synthetase [Escherichia coli O157:H7 str. TW14588],... gi\|227886780, gi... - gi\|227886780\|ref\|ZP_04004585.1\| adenylosuccinate synthetase [Escherichia coli 83972], gi\|227836353\|g... PURA_ECOLI - Adenylosuccinate synthetase (EC 6.3.4.4) (IMP--aspartate ligase) (AdSS) (AMPSase) - Escherichia coli PURA_ECO45 - Adenylosuccinate synthetase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=purA PE=3 SV=1 gi\|226901756, gi... - gi\|237703844\|ref\|ZP_04534325.1\| adenylosuccinate synthetase [Escherichia sp. 3_2_53FAA], gi\|22690175... PURA_ECOL6 - Adenylosuccinate synthetase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=purA P... PURA_ECO8A - Adenylosuccinate synthetase OS=Escherichia coli O8 (strain IAI1) GN=purA PE=3 SV=1 PURA_ECOBW - Adenylosuccinate synthetase OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=purA PE=3 SV=1 PURA_ECO57 - Adenylosuccinate synthetase OS=Escherichia coli O157:H7 GN=purA PE=3 SV=2 gi\|189376057, gi... - gi\|189376057\|gb\|EDU94473.1\| adenylosuccinate synthetase [Escherichia coli O157:H7 str. EC508], gi\|16... gi\|242379699, gi... - gi\|251787426\|ref\|YP_003001730.1\| hypothetical protein B21_04006 [Escherichia coli BL21], gi\|24237969... EG10790 - adenylosuccinate synthetase / Adenylosuccinate synthase, purine synthesis gi\|189374841, gi... - gi\|189374841\|gb\|EDU93257.1\| adenylosuccinate synthetase [Escherichia coli O157:H7 str. EC869], gi\|16... gi\|253980163, gi... - gi\|254290856\|ref\|YP_003056604.1\| adenylosuccinate synthetase [Escherichia coli BL21(DE3)], gi\|253980... PURA_ECOSM - Adenylosuccinate synthetase OS=Escherichia coli (strain SMS-3-5 / SECEC) GN=purA PE=3 SV=1 gi\|254037191, gi... - gi\|254037191\|ref\|ZP_04871268.1\| adenylosuccinate synthetase [Escherichia sp. 1_1_43], gi\|226840297\|g... PURA_ECODH - Adenylosuccinate synthetase OS=Escherichia coli (strain K12 / DH10B) GN=purA PE=3 SV=1 gi\|253976007, gi... - gi\|254164106\|ref\|YP_003047214.1\| adenylosuccinate synthetase [Escherichia coli B str. REL606], gi\|25... gi\|195935967 - gi\|195935967\|ref\|ZP_03081349.1\| adenylosuccinate synthetase [Escherichia coli O157:H7 str. EC4024] gi\|254796196, gi... - gi\|254796196\|ref\|YP_003081033.1\| adenylosuccinate synthetase [Escherichia coli O157:H7 str. TW14359]... gi\|194417174, gi... - gi\|194434589\|ref\|ZP_03066846.1\| adenylosuccinate synthetase [Shigella dysenteriae 1012], gi\|19441717... gi\|208734634, gi... - gi\|208813357\|ref\|ZP_03254686.1\| adenylosuccinate synthetase [Escherichia coli O157:H7 str. EC4045], ... gi\|208809439, gi... - gi\|208809439\|ref\|ZP_03251776.1\| adenylosuccinate synthetase [Escherichia coli O157:H7 str. EC4206], ...	0.0	[3..431]	[5..428]

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Predicted Domain #1

Region A: Residues: [1-5]	1 11 21 31 41 51 \| \| \| \| \| \| 1 MVNVV [Run NCBI BLAST on this sequence.]
Region B: Residues: [18-102]	1 11 21 31 41 51 \| \| \| \| \| \| 1 LVDLLVGKYD IVARCAGGNN AGHTIVVDGV KYDFHMLPSG LVNPNCQNLL GNGVVIHVPS 60 61 FFKELETLEA KGLKNARSRL FVSSR [Run NCBI BLAST on this sequence.]
Region C: Residues: [205-229]	1 11 21 31 41 51 \| \| \| \| \| \| 1 PFVVDSVVFM HNAIEAKKKI LVEGA [Run NCBI BLAST on this sequence.]
Region D: Residues: [242-267]	1 11 21 31 41 51 \| \| \| \| \| \| 1 PYVTSSNTGI GGVLTGLGIP PRTIDE [Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	2470.0
Match:	1j4bA_
Description:	Adenylosuccinate synthetase, PurA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nucleobase, nucleoside, nucleotide kinase activity	3.66392587433723	bayes_pls_golite062009
binding	2.64537357529343	bayes_pls_golite062009
nucleotide kinase activity	2.24094813695083	bayes_pls_golite062009
nucleic acid binding	2.11222585187695	bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor	1.96697952975573	bayes_pls_golite062009
DNA binding	1.7904783386531	bayes_pls_golite062009
transcription regulator activity	1.68903321260301	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	1.24165037431695	bayes_pls_golite062009
purine ribonucleotide binding	1.1110976601505	bayes_pls_golite062009
ribonucleotide binding	1.11103644113672	bayes_pls_golite062009
purine nucleotide binding	1.1086792521709	bayes_pls_golite062009
nucleotide binding	1.1060655022247	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
ATP binding	0.80197288940364	bayes_pls_golite062009
adenyl ribonucleotide binding	0.770085840885632	bayes_pls_golite062009
adenyl nucleotide binding	0.751575230566049	bayes_pls_golite062009
transcription factor activity	0.603758349693077	bayes_pls_golite062009
adenylate kinase activity	0.447752711852745	bayes_pls_golite062009
kinase activity	0.431162005044036	bayes_pls_golite062009
structural constituent of ribosome	0.396187998943318	bayes_pls_golite062009
translation regulator activity	0.29096092258568	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	0.277694966071518	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.274994961137851	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.250756824614616	bayes_pls_golite062009
protein binding	0.170837278876362	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	0.126821629333317	bayes_pls_golite062009
helicase activity	0.0775311459068899	bayes_pls_golite062009

Predicted Domain #2

Region A: Residues: [6-17]	1 11 21 31 41 51 \| \| \| \| \| \| 1 LGSQWGDEGK GK [Run NCBI BLAST on this sequence.]
Region B: Residues: [103-204]	1 11 21 31 41 51 \| \| \| \| \| \| 1 AHLVFDFHQV TDKLRELELS GRSKDGKNIG TTGKGIGPTY STKASRSGLR VHHLVNDQPG 60 61 AWEEFVARYK RLLETRRQRY GDFEYDFEAK LAEYKKLREQ LK [Run NCBI BLAST on this sequence.]
Region C: Residues: [230-241]	1 11 21 31 41 51 \| \| \| \| \| \| 1 NALMLDIDFG TY [Run NCBI BLAST on this sequence.]
Region D: Residues: [268-274]	1 11 21 31 41 51 \| \| \| \| \| \| 1 IYGVVKA [Run NCBI BLAST on this sequence.]
Region E: Residues: [320-348]	1 11 21 31 41 51 \| \| \| \| \| \| 1 VLKYSTLING YTSLNITKLD VLDTFKEIP [Run NCBI BLAST on this sequence.]
Region F: Residues: [379-433]	1 11 21 31 41 51 \| \| \| \| \| \| 1 VLPGWDQDIT KITKYEDLPE NAKKYLKYIE DFVGVPVEWV GTGPARESML HKEIK [Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	2470.0
Match:	1j4bA_
Description:	Adenylosuccinate synthetase, PurA
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [275-319]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YTTRVGEGPF PTEQLNENGE KLQTIGAEFG VTTGRKRRCG WLDLV

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [349-378]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGISYSIQGK KLDLFPEDLN ILGKVEVEYK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	2470.0
Match:	1j4bA_
Description:	Adenylosuccinate synthetase, PurA
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: