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Protein Overview: EG10790

General Information:
Name(s) found: purA / EG10790 [EcoGene]
Description(s) found:
Found 5 descriptions.
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  • adenylosuccinate synthetase / Adenylosuccinate synthase, purine synthesis [EcoGene]
    • Organism: Escherichia coli str. K-12 substr. MG1655
    Length: 432 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [IDALink to PubMed article]
    cytoplasm [ICLink to PubMed article][IEA]
    membrane [IDALink to PubMed article]
    Biological Process: adenosine biosynthetic process [IMPLink to PubMed article]
    purine nucleotide biosynthetic process [IEA][IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    nucleobase, nucleoside and nucleotide interconversion [IDALink to PubMed article]
    Molecular Function: GTP binding [IEA]
    magnesium ion binding [IEA]
    nucleotide binding [IEA]
    protein binding [IPILink to PubMed article]
    adenylosuccinate synthase activity [IDALink to PubMed articleLink to PubMed article][IEA]
    metal ion binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGNNVVVLGT QWGDEGKGKI VDLLTERAKY VVRYQGGHNA GHTLVINGEK TVLHLIPSGI  60
   61 LRENVTSIIG NGVVLSPAAL MKEMKELEDR GIPVRERLLL SEACPLILDY HVALDNAREK 120
  121 ARGAKAIGTT GRGIGPAYED KVARRGLRVG DLFDKETFAE KLKEVMEYHN FQLVNYYKAE 180
  181 AVDYQKVLDD TMAVADILTS MVVDVSDLLD QARQRGDFVM FEGAQGTLLD IDHGTYPYVT 240
  241 SSNTTAGGVA TGSGLGPRYV DYVLGILKAY STRVGAGPFP TELFDETGEF LCKQGNEFGA 300
  301 TTGRRRRTGW LDTVAVRRAV QLNSLSGFCL TKLDVLDGLK EVKLCVAYRM PDGREVTTTP 360
  361 LAADDWKGVE PIYETMPGWS ESTFGVKDRS GLPQAALNYI KRIEELTGVP IDIISTGPDR 420
  421 TETMILRDPF DA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..432] PSI-BLAST 1000.0 Adenylosuccinate synthetase, PurA

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • nucleobase, nucleoside, nucleotide kinase activity
    		•  3.66392587433723 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • nucleotide kinase activity
    		•  2.24094813695083 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.11222585187695 bayes_pls_golite062009
  • phosphotransferase activity, phosphate group as acceptor
    		•  1.96697952975573 bayes_pls_golite062009
  • DNA binding
    		•  1.7904783386531 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.68903321260301 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  1.24165037431695 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.1110976601505 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.11103644113672 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.1086792521709 bayes_pls_golite062009
  • nucleotide binding
    		•  1.1060655022247 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • ATP binding
    		•  0.80197288940364 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.770085840885632 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.751575230566049 bayes_pls_golite062009
  • transcription factor activity
    		•  0.603758349693077 bayes_pls_golite062009
  • adenylate kinase activity
    		•  0.447752711852745 bayes_pls_golite062009
  • kinase activity
    		•  0.431162005044036 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.396187998943318 bayes_pls_golite062009
  • translation regulator activity
    		•  0.29096092258568 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  0.277694966071518 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.274994961137851 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.250756824614616 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  0.126821629333317 bayes_pls_golite062009
  • helicase activity
    		•  0.0775311459068899 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle