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View Structure Prediction Details

Protein: HSH155
Organism: Saccharomyces cerevisiae
Length: 971 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HSH155.

Description E-value Query
Range
Subject
Range
SF3B1_MOUSE - Splicing factor 3B subunit 1 OS=Mus musculus GN=Sf3b1 PE=1 SV=1
0.0 [72..971] [387..1304]
SF3B1_YEAST - U2 snRNP component HSH155 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HSH155 PE=1 SV...
HSH155 - U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice...
0.0 [1..971] [1..971]
SF3B1_XENLA - Splicing factor 3B subunit 1 OS=Xenopus laevis GN=sf3b1 PE=2 SV=1
0.0 [72..971] [390..1307]
CE03641 - status:Partially_confirmed UniProt:Q21909 protein_id:CAA90777.1
0.0 [70..971] [392..1322]
gi|15237657, gi|... - gi|9759403|dbj|BAB09858.1| nuclear protein-like [Arabidopsis thaliana], gi|15237657|ref|NP_201232.1|...
0.0 [72..971] [350..1267]
SF3B1_SCHPO - U2 snRNP component prp10 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=prp10 PE=1 SV=2
prp10 - U2 snRNP-associated protein Sap155
0.0 [22..960] [270..1192]
SF3B1_SCHPO - U2 snRNP component prp10 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=prp10 PE=1 SV=2
prp10 - U2 snRNP-associated protein Sap155
0.0 [22..960] [253..1175]
gi|7494200 - pir||T18434 hypothetical protein C0375c - malaria parasite (Plasmodium falciparum)
gi|16805179, gi|... - gi|3649762|emb|CAB11111.1| U2 snRNP spliceosome subunit, putative [Plasmodium falciparum 3D7], gi|16...
0.0 [119..971] [531..1386]

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Predicted Domain #1
Region A:
Residues: [1-71]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSHPIQFVNA NNSDKSHQLG GQYSIPQDLR ENLQKEAARI GENEKDVLQE KMETRTVQNR  60
   61 EDSYHKRRFD M

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.409 a.77.1 DEATH domain
View Download 0.359 a.74.1 Cyclin-like
View Download 0.371 a.108.1 Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View Download 0.521 a.118.11 Cytochrome c oxidase subunit E
View Download 0.464 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.339 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.338 a.5.3 N-terminal domain of phosphatidylinositol transfer protein sec14p
View Download 0.336 a.39.1 EF-hand
View Download 0.326 a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.288 a.5.2 UBA-like
View Download 0.286 d.74.2 C-terminal domain of arginine repressor
View Download 0.284 b.7.2 Periplasmic chaperone C-domain
View Download 0.267 a.5.7 4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View Download 0.258 a.7.6 Ribosomal protein S20
View Download 0.249 a.150.1 Anti-sigma factor AsiA
View Download 0.243 a.74.1 Cyclin-like
View Download 0.241 a.157.1 Skp1 dimerisation domain-like
View Download 0.240 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.237 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.231 a.60.1 SAM/Pointed domain
View Download 0.221 a.3.1 Cytochrome c
View Download 0.220 a.64.1 Saposin
View Download 0.219 a.21.1 HMG-box
View Download 0.209 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.205 a.138.1 Multiheme cytochromes
View Download 0.203 a.43.1 Met repressor-like
View Download 0.201 a.43.1 Met repressor-like

Predicted Domain #2
Region A:
Residues: [72-173]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KFEPDSDTQT VTSSENTQDA VVPRKRKSRW DVKGYEPPDE SSTAVKENSD SALVNVEGIH  60
   61 DLMFFKPSDH KYFADVISKK PIDELNKDEK KERTLSMLLL KI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.248 0.062 U2 snRNP a.11.2 Second domain of FERM
View Download 0.263 0.047 U2 snRNP d.110.4 SNARE-like
View Download 0.220 0.032 U2 snRNP a.24.16 Nucleotidyltransferase substrate binding subunit/domain

Predicted Domain #3
Region A:
Residues: [174-253]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KNGNTASRRT SMRILTDKAV TFGPEMIFNR LLPILLDRSL EDQERHLMIK TIDRVLYQLG  60
   61 DLTKPYVHKI LVVAAPLLID 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.917 0.054 U2 snRNP a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.913 0.054 U2 snRNP a.118.9 ENTH/VHS domain
View Download 0.964 0.054 U2 snRNP a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.848 0.054 U2 snRNP a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.844 0.054 U2 snRNP a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.772 0.054 U2 snRNP a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.737 0.054 U2 snRNP a.24.17 Group V grass pollen allergen
View Download 0.735 0.054 U2 snRNP a.23.5 Hemolysin expression modulating protein HHA
View Download 0.700 0.054 U2 snRNP a.118.1 ARM repeat
View Download 0.700 0.054 U2 snRNP a.2.4 Theta subunit of DNA polymerase III
View Download 0.686 0.054 U2 snRNP a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.686 0.054 U2 snRNP d.68.1 Translation initiation factor IF3, C-terminal domain
View Download 0.660 0.054 U2 snRNP a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.649 0.054 U2 snRNP a.64.1 Saposin
View Download 0.644 0.054 U2 snRNP a.7.6 Ribosomal protein S20
View Download 0.639 0.054 U2 snRNP a.49.1 C-terminal domain of B transposition protein
View Download 0.633 0.054 U2 snRNP a.29.4 RecG, N-terminal domain
View Download 0.600 0.054 U2 snRNP d.58.20 NAD-binding domain of HMG-CoA reductase
View Download 0.565 0.054 U2 snRNP a.157.1 Skp1 dimerisation domain-like
View Download 0.556 0.054 U2 snRNP a.118.11 Cytochrome c oxidase subunit E
View Download 0.549 0.054 U2 snRNP a.77.1 DEATH domain
View Download 0.538 0.054 U2 snRNP a.126.1 Serum albumin-like
View Download 0.531 0.054 U2 snRNP a.118.8 TPR-like
View Download 0.509 0.054 U2 snRNP f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.509 0.054 U2 snRNP a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.506 0.054 U2 snRNP a.37.1 A DNA-binding domain in eukaryotic transcription factors
View Download 0.498 0.054 U2 snRNP a.28.3 Retrovirus capsid protein C-terminal domain
View Download 0.498 0.054 U2 snRNP a.101.1 Uteroglobin-like
View Download 0.493 0.054 U2 snRNP a.118.13 Arp2/3 complex 16 kDa subunit ARPC5
View Download 0.493 0.054 U2 snRNP a.51.1 Cytochrome c oxidase subunit h
View Download 0.484 0.054 U2 snRNP a.85.1 Hemocyanin, N-terminal domain
View Download 0.473 0.054 U2 snRNP a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.467 0.054 U2 snRNP a.60.2 RuvA domain 2-like
View Download 0.462 0.054 U2 snRNP a.144.1 PABC (PABP) domain
View Download 0.454 0.054 U2 snRNP a.65.1 Annexin
View Download 0.444 0.054 U2 snRNP a.4.1 Homeodomain-like
View Download 0.424 0.054 U2 snRNP a.60.9 lambda integrase-like, N-terminal domain
View Download 0.423 0.054 U2 snRNP a.151.1 Glutamyl tRNA-reductase dimerization domain
View Download 0.414 0.054 U2 snRNP a.24.3 Cytochromes
View Download 0.406 0.054 U2 snRNP a.4.5 "Winged helix" DNA-binding domain
View Download 0.405 0.054 U2 snRNP a.2.7 tRNA-binding arm
View Download 0.399 0.054 U2 snRNP a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.388 0.054 U2 snRNP a.4.5 "Winged helix" DNA-binding domain
View Download 0.383 0.054 U2 snRNP a.165.1 Myosin phosphatase inhibitor 17kDa protein, CPI-17
View Download 0.374 0.054 U2 snRNP a.3.1 Cytochrome c
View Download 0.369 0.054 U2 snRNP a.57.1 Protein HNS-dependent expression A; HdeA
View Download 0.360 0.054 U2 snRNP a.29.2 Bromodomain
View Download 0.352 0.054 U2 snRNP a.24.4 Hemerythrin
View Download 0.348 0.054 U2 snRNP a.4.5 "Winged helix" DNA-binding domain
View Download 0.334 0.054 U2 snRNP a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.333 0.054 U2 snRNP a.4.5 "Winged helix" DNA-binding domain
View Download 0.328 0.054 U2 snRNP f.17.1 F1F0 ATP synthase subunit C
View Download 0.327 0.054 U2 snRNP a.23.4 Mitochondrial import receptor subunit Tom20
View Download 0.326 0.054 U2 snRNP a.158.1 F-box domain
View Download 0.325 0.054 U2 snRNP a.29.2 Bromodomain
View Download 0.325 0.054 U2 snRNP a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.320 0.054 U2 snRNP a.118.8 TPR-like
View Download 0.319 0.054 U2 snRNP a.61.1 Retroviral matrix proteins
View Download 0.315 0.054 U2 snRNP a.118.8 TPR-like
View Download 0.315 0.054 U2 snRNP a.39.1 EF-hand
View Download 0.311 0.054 U2 snRNP a.2.3 Chaperone J-domain
View Download 0.311 0.054 U2 snRNP a.35.1 lambda repressor-like DNA-binding domains
View Download 0.311 0.054 U2 snRNP a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.310 0.054 U2 snRNP a.159.1 Protein serine/threonine phosphatase 2C, C-terminal domain
View Download 0.306 0.054 U2 snRNP c.58.1 Aminoacid dehydrogenase-like, N-terminal domain
View Download 0.305 0.054 U2 snRNP a.39.3 Cloroperoxidase
View Download 0.301 0.054 U2 snRNP a.61.1 Retroviral matrix proteins
View Download 0.299 0.054 U2 snRNP a.140.4 Recombination endonuclease VII, C-terminal and dimerization domains
View Download 0.298 0.054 U2 snRNP a.142.1 PTS-regulatory domain, PRD
View Download 0.298 0.054 U2 snRNP a.64.1 Saposin
View Download 0.296 0.054 U2 snRNP a.29.2 Bromodomain
View Download 0.296 0.054 U2 snRNP a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.294 0.054 U2 snRNP a.46.1 Methionine synthase domain
View Download 0.291 0.054 U2 snRNP a.58.1 Chemotaxis receptor methyltransferase CheR, N-terminal domain
View Download 0.280 0.054 U2 snRNP a.118.1 ARM repeat
View Download 0.279 0.054 U2 snRNP d.87.2 CO dehydrogenase flavoprotein C-terminal domain-like
View Download 0.279 0.054 U2 snRNP a.71.1 Endoplasmic reticulum protein ERP29, C-domain
View Download 0.278 0.054 U2 snRNP a.112.1 Description not found.
View Download 0.273 0.054 U2 snRNP a.16.1 S15/NS1 RNA-binding domain
View Download 0.272 0.054 U2 snRNP a.153.1 Nuclear receptor coactivator interlocking domain
View Download 0.271 0.054 U2 snRNP a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.271 0.054 U2 snRNP a.164.1 C-terminal domain of DFF45/ICAD (DFF-C domain)
View Download 0.269 0.054 U2 snRNP a.24.3 Cytochromes
View Download 0.268 0.054 U2 snRNP a.47.2 t-snare proteins
View Download 0.263 0.054 U2 snRNP a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.260 0.054 U2 snRNP a.4.5 "Winged helix" DNA-binding domain
View Download 0.260 0.054 U2 snRNP a.24.9 alpha-catenin/vinculin
View Download 0.259 0.054 U2 snRNP a.35.1 lambda repressor-like DNA-binding domains
View Download 0.254 0.054 U2 snRNP a.118.9 ENTH/VHS domain
View Download 0.251 0.054 U2 snRNP a.39.1 EF-hand
View Download 0.247 0.054 U2 snRNP a.4.1 Homeodomain-like
View Download 0.246 0.054 U2 snRNP a.23.3 Methane monooxygenase hydrolase, gamma subunit
View Download 0.245 0.054 U2 snRNP a.8.3 Families 57/38 glycoside transferase middle domain
View Download 0.245 0.054 U2 snRNP a.39.1 EF-hand
View Download 0.245 0.054 U2 snRNP a.48.1 N-terminal domain of cbl (N-cbl)
View Download 0.243 0.054 U2 snRNP d.228.1 Replication modulator SeqA, C-terminal DNA-binding domain
View Download 0.243 0.054 U2 snRNP a.3.1 Cytochrome c
View Download 0.242 0.054 U2 snRNP a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.242 0.054 U2 snRNP a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.239 0.054 U2 snRNP a.4.1 Homeodomain-like
View Download 0.238 0.054 U2 snRNP a.4.1 Homeodomain-like
View Download 0.231 0.054 U2 snRNP d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.229 0.054 U2 snRNP a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.228 0.054 U2 snRNP a.24.15 FAD-dependent thiol oxidase
View Download 0.227 0.054 U2 snRNP a.130.1 Chorismate mutase II
View Download 0.227 0.054 U2 snRNP a.25.2 Thermoplasma ferritin-like 4-helical bundle
View Download 0.226 0.054 U2 snRNP c.51.3 B12-dependend dehydatases associated subunit
View Download 0.226 0.054 U2 snRNP b.82.4 Regulatory protein AraC
View Download 0.221 0.054 U2 snRNP a.4.5 "Winged helix" DNA-binding domain
View Download 0.220 0.054 U2 snRNP a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.218 0.054 U2 snRNP f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.218 0.054 U2 snRNP a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.218 0.054 U2 snRNP a.7.5 Tubulin chaperone cofactor A
View Download 0.216 0.054 U2 snRNP a.108.1 Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View Download 0.215 0.054 U2 snRNP d.58.39 Glutamyl tRNA-reductase catalytic, N-terminal domain
View Download 0.214 0.054 U2 snRNP a.76.1 Iron-dependent represor protein, dimerization domain
View Download 0.212 0.054 U2 snRNP e.20.1 Heat shock protein 70kD (HSP70), C-terminal substrate-binding fragment
View Download 0.210 0.054 U2 snRNP a.39.1 EF-hand
View Download 0.209 0.054 U2 snRNP a.5.4 Elongation factor TFIIS domain 2
View Download 0.209 0.054 U2 snRNP a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.208 0.054 U2 snRNP a.78.1 Fatty acid responsive transcription factor FadR, C-terminal domain
View Download 0.207 0.054 U2 snRNP d.68.7 R3H domain
View Download 0.206 0.054 U2 snRNP d.192.1 YlxR-like
View Download 0.203 0.054 U2 snRNP d.74.1 Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)
View Download 0.201 0.054 U2 snRNP a.118.1 ARM repeat

Predicted Domain #4
Region A:
Residues: [254-363]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDPMVRSTGQ EIITNLSTVA GLKTILTVMR PDIENEDEYV RNVTSRAAAV VAKALGVNQL  60
   61 LPFINAACHS RKSWKARHTG IKIVQQIGIL LGIGVLNHLT GLMSCIKDCL 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 82.39794
Match: 1b3uA_
Description: Constant regulatory domain of protein phosphatase 2a, pr65alpha
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 4.20683443264388 bayes_pls_golite062009
binding 2.91891696274037 bayes_pls_golite062009
mRNA binding 2.49094746544717 bayes_pls_golite062009
protein binding 1.75981610748679 bayes_pls_golite062009
nucleic acid binding 1.64539435934931 bayes_pls_golite062009
structural molecule activity 1.39201458088376 bayes_pls_golite062009
transcription regulator activity 1.06250847754412 bayes_pls_golite062009
DNA binding 0.946847037737779 bayes_pls_golite062009
RNA cap binding 0.66277586901495 bayes_pls_golite062009
transcription factor activity 0.362911773502049 bayes_pls_golite062009
signal sequence binding 0.289133192719901 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [364-747]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDHVPVRIV TAHTLSTLAE NSYPYGIEVF NVVLEPLWKG IRSHRGKVLS SFLKAVGSMI  60
   61 PLMDPEYAGY YTTEAMRIIR REFDSPDDEM KKTILLVLQK CSAVESITPK FLREEIAPEF 120
  121 FQKFWVRRVA LDRPLNKVVT YTTVTLAKKL GCSYTIDKLL TPLRDEAEPF RTMAVHAVTR 180
  181 TVNLLGTADL DERLETRLID ALLIAFQEQT NSDSIIFKGF GAVTVSLDIR MKPFLAPIVS 240
  241 TILNHLKHKT PLVRQHAADL CAILIPVIKN CHEFEMLNKL NIILYESLGE VYPEVLGSII 300
  301 NAMYCITSVM DLDKLQPPIN QILPTLTPIL RNKHRKVEVN TIKFVGLIGK LAPTYAPPKE 360
  361 WMRICFELLE LLKSTNKEIR RSAN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 55.0
Match: 1qgkA_
Description: Importin beta
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [748-971]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATFGFIAEAI GPHDVLVALL NNLKVQERQL RVCTAVAIGI VAKVCGPYNV LPVIMNEYTT  60
   61 PETNVQNGVL KAMSFMFEYI GNMSKDYIYF ITPLLEDALT DRDLVHRQTA SNVITHLALN 120
  121 CSGTGHEDAF IHLMNLLIPN IFETSPHAIM RILEGLEALS QALGPGLFMN YIWAGLFHPA 180
  181 KNVRKAFWRV YNNMYVMYQD AMVPFYPVTP DNNEEYIEEL DLVL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 55.0
Match: 1qgkA_
Description: Importin beta
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle