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View Structure Prediction Details

Protein: ARA2
Organism: Saccharomyces cerevisiae
Length: 335 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ARA2.

Description E-value Query
Range		 Subject
Range
gi|15208400 - gi|15208400|dbj|BAB63207.1| 3(20)alpha-hydroxysteroid/dihydrodiol/indanol dehydrogenase [Macaca fusc...
AK1C1_MACFU - Aldo-keto reductase family 1 member C1 homolog OS=Macaca fuscata fuscata GN=AKR1C1 PE=2 SV=1
gi|109088079, gi... - gi|109088083|ref|XP_001103887.1| PREDICTED: aldo-keto reductase family 1, member C1 isoform 5 [Macac...
 2.0E-97 [2..325] [4..319]
gi|60654665, gi|... - gi|60654667|gb|AAX31898.1| aldo-keto reductase family 1 member C1 [synthetic construct], gi|60654665...
AKR1C1 - aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxyster...
 2.0E-96 [2..325] [4..319]
AK1C1_MACFA - Aldo-keto reductase family 1 member C1 homolog OS=Macaca fascicularis GN=AKR1C1 PE=1 SV=1
 2.0E-96 [2..325] [4..319]
PGFS1_BOVIN - Prostaglandin F synthase 1 OS=Bos taurus PE=1 SV=3
 6.0E-96 [2..333] [4..316]
DHB5_MOUSE - Estradiol 17 beta-dehydrogenase 5 OS=Mus musculus GN=Akr1c6 PE=1 SV=1
 1.0E-95 [2..325] [4..319]
PE2R_RABIT - Prostaglandin-E(2) 9-reductase OS=Oryctolagus cuniculus GN=AKR1C5 PE=1 SV=1
 2.0E-94 [2..325] [4..319]

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Predicted Domain #1
Region A:
Residues: [1-222] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVNEKVNPFD LASVSPLVLG GAILNQQYTD EPESIPLEDI IKYAFSHGIN AIDTSPYYGP  60
   61 SEVLYGRALS NLRNEFPRDT YFICTKVGRI GAEEFNYSRD FVRFSVHRSC ERLHTTYLDL 120
  121 VYLHDVEFVK FPDILEALKE LRTLKNKGVI KNFGISGYPI DFITWLAEYC STEESDIGSL 180
  181 DAVLSYCNLN LQNNKLLNFR ERLLRNAKLK MVCNASILSM SL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [254-302] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VDLADLATRY AISEWVGKGP VVLGVSSMEE LKLALDNYEI VKSNGNRLS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 104.703922
Match: 1exbA_
Description: Voltage-dependent K+ channel beta subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
potassium channel activity 7.51963276589303 bayes_pls_golite062009
voltage-gated potassium channel activity 7.40239094355354 bayes_pls_golite062009
voltage-gated cation channel activity 6.67507110634301 bayes_pls_golite062009
metal ion transmembrane transporter activity 6.588881463055 bayes_pls_golite062009
voltage-gated ion channel activity 6.52286930358188 bayes_pls_golite062009
voltage-gated channel activity 6.50716590143831 bayes_pls_golite062009
cation channel activity 5.72172645555113 bayes_pls_golite062009
ion channel activity 5.15119282480682 bayes_pls_golite062009
passive transmembrane transporter activity 5.07214658557001 bayes_pls_golite062009
channel activity 5.07214658557001 bayes_pls_golite062009
substrate-specific channel activity 5.02503292701043 bayes_pls_golite062009
gated channel activity 4.92848832197692 bayes_pls_golite062009
ion transmembrane transporter activity 2.63772951680109 bayes_pls_golite062009
cation transmembrane transporter activity 2.58068601897668 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.46488926936937 bayes_pls_golite062009
catalytic activity 1.68179794468736 bayes_pls_golite062009
transporter activity 1.24767072239634 bayes_pls_golite062009
transmembrane transporter activity 1.03420335553507 bayes_pls_golite062009
potassium channel regulator activity 1.03017249802223 bayes_pls_golite062009
substrate-specific transporter activity 0.783004917746429 bayes_pls_golite062009
oxidoreductase activity 0.538083956961548 bayes_pls_golite062009
binding 0.214346441566082 bayes_pls_golite062009
0.139676323362391 bayes_pls_golite062009
channel regulator activity 0.12154513851913 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.0465377885825481 bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors 0.0143508436041874 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [223-253] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LRSQETRQFH PCSHELRECA SQAAKYCQEQ N

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [303-335] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKDGQLVEYI QKNIFKEHFN EEWSSGIPHP EMI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 104.703922
Match: 1exbA_
Description: Voltage-dependent K+ channel beta subunit
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle