YRC Public Data Repository - Protein Structure Prediction

Protein:	TUB1
Organism:	Saccharomyces cerevisiae
Length:	447 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TUB1.

Description	E-value	Query Range	Subject Range
gi\|157767470 - gi\|157767470\|ref\|XP_001667215.1\| Hypothetical protein CBG16137 [Caenorhabditis briggsae AF16] tbb-4 - tubulin beta chain status:Partially_confirmed UniProt:P41937 protein_id:CAA86310.1 gi\|39596183, gi\|... - gi\|39596183\|emb\|CAE69820.1\| Hypothetical protein CBG16137 [Caenorhabditis briggsae], gi\|187026681\|em...	0.0	[1..447]	[1..436]
gi\|17402390 - gi\|17402390\|emb\|CAC82577.1\| beta-tubulin [Fasciola hepatica]	0.0	[1..447]	[1..436]
gi\|2443346 - gi\|2443346\|dbj\|BAA22382.1\| beta-tubulin [Halocynthia roretzi]	0.0	[1..441]	[1..430]
gi\|10242186 - gi\|10242186\|gb\|AAG15328.1\|AF255954_1 beta tubulin [Chionodraco rastrospinosus] gi\|10242160 - gi\|10242160\|gb\|AAG15315.1\|AF255553_1 beta tubulin [Notothenia coriiceps]	0.0	[1..441]	[1..430]
TBB4_XENLA - Tubulin beta-4 chain OS=Xenopus laevis GN=tubb4 PE=2 SV=1	0.0	[1..441]	[1..430]
TBB_PARLI - Tubulin beta chain OS=Paracentrotus lividus PE=2 SV=1	0.0	[1..441]	[1..430]
gi\|19773428, gi\|... - gi\|19773428\|dbj\|BAB86853.1\| beta-tubulin [Bombyx mori], gi\|112983318\|ref\|NP_001036964.1\| beta-tubuli...	0.0	[1..444]	[1..433]
TBB1_MANSE - Tubulin beta-1 chain OS=Manduca sexta PE=2 SV=1	0.0	[1..444]	[1..433]

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Predicted Domain #1

Region A:
Residues: [1-447]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MREVISINVG QAGCQIGNAC WELYSLEHGI KPDGHLEDGL SKPKGGEEGF STFFHETGYG  60
   61 KFVPRAIYVD LEPNVIDEVR NGPYKDLFHP EQLISGKEDA ANNYARGHYT VGREILGDVL 120
  121 DRIRKLADQC DGLQGFLFTH SLGGGTGSGL GSLLLEELSA EYGKKSKLEF AVYPAPQVST 180
  181 SVVEPYNTVL TTHTTLEHAD CTFMVDNEAI YDMCKRNLDI PRPSFANLNN LIAQVVSSVT 240
  241 ASLRFDGSLN VDLNEFQTNL VPYPRIHFPL VSYSPVLSKS KAFHESNSVS EITNACFEPG 300
  301 NQMVKCDPRD GKYMATCLLY RGDVVTRDVQ RAVEQVKNKK TVQLVDWCPT GFKIGICYEP 360
  361 PTATPNSQLA TVDRAVCMLS NTTSIAEAWK RIDRKFDLMY AKRAFVHWYV GEGMEEGEFT 420
  421 EAREDLAALE RDYIEVGADS YAEEEEF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	11000.0
Match:	1ffxA_
Description:	Tubulin:stathmin-like domain complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
structural constituent of cytoskeleton	4.04224160177678	bayes_pls_golite062009
structural molecule activity	3.32779015200848	bayes_pls_golite062009
tubulin binding	2.4432045213385	bayes_pls_golite062009
cytoskeletal protein binding	2.24606230377981	bayes_pls_golite062009
binding	2.00508289492248	bayes_pls_golite062009
GTPase activity	1.87512665946067	bayes_pls_golite062009
nucleoside-triphosphatase activity	1.77500173070686	bayes_pls_golite062009
pyrophosphatase activity	1.7017047947554	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	1.68267378160702	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.68038087466376	bayes_pls_golite062009
protein binding	1.60795853516357	bayes_pls_golite062009
MHC class I protein binding	1.46574865275013	bayes_pls_golite062009
gamma-tubulin binding	1.02742779831447	bayes_pls_golite062009
hydrolase activity	0.502038132260603	bayes_pls_golite062009
receptor binding	0.00945891657658993	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: