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View Structure Prediction Details

Protein: PRP39
Organism: Saccharomyces cerevisiae
Length: 629 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRP39.

Description E-value Query
Range
Subject
Range
PRP39 - U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats
PRP39_YEAST - Pre-mRNA-processing factor 39 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRP39 PE=1...
0.0 [1..629] [1..629]
gi|13775066 - gi|13775066|gb|AAK39123.1|AF363030_1 UDP-N-acetylglucosaminyltransferase [Mus musculus]
4.0E-60 [80..501] [81..503]
OGT1_RAT - UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Rattus norvegicu...
4.0E-60 [80..501] [71..493]
OGT - O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylgluco...
gi|123993895, gi... - gi|224487755|dbj|BAH24112.1| O-linked N-acetylglucosamine (GlcNAc) transferase [synthetic construct]...
8.0E-60 [80..501] [71..493]
gi|5052534 - gi|5052534|gb|AAD38597.1|AF145622_1 BcDNA.GH04245 [Drosophila melanogaster]
1.0E-58 [80..501] [110..532]
SEC_ARATH - Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SEC OS=Arabidopsis thalian...
8.0E-57 [33..501] [68..535]
ogt-1 - status:Confirmed UniProt:O18158 protein_id:AAA62535.2
1.0E-54 [20..496] [134..595]

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Predicted Domain #1
Region A:
Residues: [1-64]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPDETNFTIE DIEPRPDALR GLDTQFLQDN TALVQAYRGL DWSDISSLTQ MVDVIEQTVV  60
   61 KYGN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.456 a.60.1 SAM/Pointed domain
View Download 0.534 a.36.1 Signal peptide-binding domain
View Download 0.425 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.569 a.60.11 Hypothetical protein YjbJ
View Download 0.452 a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.406 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.405 a.4.11 RNA polymerase subunit RPB10
View Download 0.400 a.144.2 Ribosomal protein L20
View Download 0.392 a.4.1 Homeodomain-like
View Download 0.371 a.23.5 Hemolysin expression modulating protein HHA
View Download 0.371 d.141.1 Ribosomal protein L6
View Download 0.354 a.5.7 4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View Download 0.351 a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.347 a.4.1 Homeodomain-like
View Download 0.344 a.23.5 Hemolysin expression modulating protein HHA
View Download 0.341 a.108.1 Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View Download 0.327 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.314 a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.312 a.60.2 RuvA domain 2-like
View Download 0.305 a.157.1 Skp1 dimerisation domain-like
View Download 0.300 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.293 a.60.4 DNA repair protein Rad51, N-terminal domain
View Download 0.283 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.283 a.4.1 Homeodomain-like
View Download 0.281 a.61.1 Retroviral matrix proteins
View Download 0.278 a.39.1 EF-hand
View Download 0.262 a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.257 a.156.1 S13-like H2TH domain
View Download 0.255 a.4.5 "Winged helix" DNA-binding domain
View Download 0.247 d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.244 a.60.2 RuvA domain 2-like
View Download 0.244 a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.244 a.2.9 C-terminal UvrC-binding domain of UvrB
View Download 0.241 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.241 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.240 d.51.1 Eukaryotic type KH-domain (KH-domain type I)
View Download 0.236 a.5.2 UBA-like
View Download 0.234 a.64.2 Bacteriocin AS-48
View Download 0.233 a.37.1 A DNA-binding domain in eukaryotic transcription factors
View Download 0.231 a.2.3 Chaperone J-domain
View Download 0.231 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.224 a.60.11 Hypothetical protein YjbJ
View Download 0.219 d.192.1 YlxR-like
View Download 0.217 a.164.1 C-terminal domain of DFF45/ICAD (DFF-C domain)
View Download 0.217 d.58.1 4Fe-4S ferredoxins
View Download 0.216 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.214 a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.211 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.211 a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.208 a.60.5 Barrier-to-autointegration factor, BAF
View Download 0.203 a.16.1 S15/NS1 RNA-binding domain
View Download 0.202 a.30.1 ROP protein
View Download 0.201 a.60.12 DNA polymerase beta-like, second domain
View Download 0.201 a.5.2 UBA-like
View Download 0.200 a.39.1 EF-hand

Predicted functions:

Term Confidence Notes
RNA binding 2.76684454218635 bayes_pls_golite062009
binding 2.71974493738804 bayes_pls_golite062009
transcription regulator activity 1.96129657517284 bayes_pls_golite062009
protein binding 1.6279032205159 bayes_pls_golite062009
nucleic acid binding 1.62783430593918 bayes_pls_golite062009
DNA binding 1.62663906748938 bayes_pls_golite062009
transcription factor activity 0.934706586922936 bayes_pls_golite062009
signal sequence binding 0.8574224889202 bayes_pls_golite062009
transcription factor binding 0.441518464573089 bayes_pls_golite062009
transcription cofactor activity 0.19094857768269 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [65-209]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNDSIKLALE TILWQILRKY PLLFGFWKRF ATIEYQLFGL KKSIAVLATS VKWFPTSLEL  60
   61 WCDYLNVLCV NNPNETDFIR NNFEIAKDLI GKQFLSHPFW DKFIEFEVGQ KNWHNVQRIY 120
  121 EYIIEVPLHQ YARFFTSYKK FLNEK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.221849
Match: 1fchA_
Description: Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [210-270]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLKTTRNIDI VLRKTQTTVN EIWQFESKIK QPFFNLGQVL NDDLENWSRY LKFVTDPSKS  60
   61 L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.221849
Match: 1fchA_
Description: Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [271-353]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DKEFVMSVFD RCLIPCLYHE NTWMMYIKWL TKKNISDEVV VDIYQKANTF LPLDFKTLRY  60
   61 DFLRFLKRKY RSNNTLFNNI FNE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.221849
Match: 1fchA_
Description: Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [354-411]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TVSRYLKIWP NDILLMTEYL CMLKRHSFKN SLDQSPKEIL EKQTSFTKIL ETSITNYI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.0
Match: 1ihgA_
Description: Cyclophilin 40; Cyclophilin 40 isomerase domain
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [412-546]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNQIDAKVHL QTLINDKNLS IVVVELIKTT WLVLKNNMQT RKYFNLYQKN ILIKNSVPFW  60
   61 LTYYKFEKSN VNFTKLNKFI RELGVEIYLP TTVMNDILTD YKTFYLTHSN IVTYESSIID 120
  121 SNTFDPILYP ELKMS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.0
Match: 1ihgA_
Description: Cyclophilin 40; Cyclophilin 40 isomerase domain
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [547-629]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPKYDPVLNT TANVDWHKKT EWKEAGHIGI TTERPQISNS IIECNSGTLI QKPISLPNFR  60
   61 NLEKINQVKI NDLYTEEFLK EGK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.207 a.3.1 Cytochrome c
View Download 0.339 d.50.1 dsRNA-binding domain-like
View Download 0.265 a.28.1 ACP-like
View Download 0.203 d.222.1 YbaB-like
View Download 0.334 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle