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View Structure Prediction Details

Protein: UBX2
Organism: Saccharomyces cerevisiae
Length: 584 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for UBX2.

Description E-value Query
Range
Subject
Range
UBX2_YEAST - UBX domain-containing protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UBX2 PE=...
UBX2 - Protein involved in ER-associated protein degradation; proposed to coordinate the assembly of protei...
0.0 [1..571] [1..571]
gi|19528655 - gi|19528655|ref|NP_572051.1| FAS-associated factor 1 isoform b [Homo sapiens]
2.0E-99 [21..505] [11..492]
PUX7_ARATH - Plant UBX domain-containing protein 7 OS=Arabidopsis thaliana GN=PUX7 PE=1 SV=1
6.0E-95 [14..511] [7..468]
Faf-PA, FBpp0309814 - The gene Fas-associated factor is referred to in FlyBase by the symbol Dmel\Faf (CG10372, FBgn002560...
gi|220955346, gi... - gi|220955346|gb|ACL90216.1| Faf-PA [synthetic construct], gi|220945460|gb|ACL85273.1| Faf-PA [synthe...
3.0E-94 [13..527] [6..463]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
1.0E-90 [19..523] [6..463]

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Predicted Domain #1
Region A:
Residues: [1-95]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPVVNHEDSE FHLSHTEEDK LNEFQVITNF PPEDLPDVVR LLRNHGWQLE PALSRYFDGE  60
   61 WKGEPDQMGE PTQTSTPMAE TLVPPALGPR PLLFT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [96-182]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASLPVVRPLP ANFRNDFRTI GLNGRSNTVW SMFESFSYDG NPFLFILLLI PRIINRLSAT  60
   61 IFTFFCTLLS LHSISGGGNS GKPKISK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [183-351]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPKAPTRETH IPLAEILGDT KDKDAFCELK SFKPDISFNE ALRIAKEEFK FMLLILVGDT  60
   61 YDTDTDTVDV NSKLLLEKIL LNKKTLQYLR KIDNDLIIYL KCVHELEPWL VARQLGVRNT 120
  121 PEIFLIANVA NKASHSETLP SQRLSILGKL KVNSLNRFLQ SLTNVVEKY

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
protein disulfide isomerase activity 2.05206748531532 bayes_pls_golite062009
intramolecular oxidoreductase activity, transposing S-S bonds 2.05206748531532 bayes_pls_golite062009
intramolecular oxidoreductase activity, interconverting keto- and enol-groups 1.83987272812734 bayes_pls_golite062009
intramolecular oxidoreductase activity 1.5535855642475 bayes_pls_golite062009
catalytic activity 0.672192331361968 bayes_pls_golite062009
protein binding 0.532751276111804 bayes_pls_golite062009
hydrolase activity 0.517269321619613 bayes_pls_golite062009
binding 0.235855919597681 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 0.0866917827040035 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [352-426]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPELVVNKTE MHELRMSREI KKLQEDAYKK SLEMDRIKAI EKEKSLKHAQ DLKLNSTARQ  60
   61 LKWLKACIDE IQPFE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
small conjugating protein ligase activity 6.3238498800949 bayes_pls_golite062009
ubiquitin-protein ligase activity 5.759996473289 bayes_pls_golite062009
acid-amino acid ligase activity 5.32190918602578 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 4.23828791893907 bayes_pls_golite062009
protein binding 2.26682390101852 bayes_pls_golite062009
ligase activity 2.25858205355159 bayes_pls_golite062009
binding 1.76448263865625 bayes_pls_golite062009
hydrolase activity 0.614233748923048 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [427-518]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TTGKQATLQF RTSSGKRFVK KFPSMTTLYQ IYQSIGCHIY LAVYSSDPAE WSNALQDKIR  60
   61 QLSADDDMLC FKEGQLETAT ATTIEELGHI IN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.154902
Match: 1h8cA_
Description: Fas-assosiated factor 1, Faf1
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [519-584]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NELTSFDLER GKLEFDFELV SPFPKYTVHP NEHMSVDQVP QLWPNGSLLV EALDEEDEED  60
   61 EENEEQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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Created and Maintained by: Michael Riffle