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View Structure Prediction Details

Protein: UBX2
Organism: Saccharomyces cerevisiae
Length: 584 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for UBX2.

Description E-value Query
Range
Subject
Range
UBX2_YEAST - UBX domain-containing protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UBX2 PE=...
UBX2 - Protein involved in ER-associated protein degradation; proposed to coordinate the assembly of protei...
0.0 [1..571] [1..571]
gi|19528655 - gi|19528655|ref|NP_572051.1| FAS-associated factor 1 isoform b [Homo sapiens]
2.0E-99 [21..505] [11..492]
PUX7_ARATH - Plant UBX domain-containing protein 7 OS=Arabidopsis thaliana GN=PUX7 PE=1 SV=1
6.0E-95 [14..511] [7..468]
Faf-PA, FBpp0309814 - The gene Fas-associated factor is referred to in FlyBase by the symbol Dmel\Faf (CG10372, FBgn002560...
gi|220955346, gi... - gi|220955346|gb|ACL90216.1| Faf-PA [synthetic construct], gi|220945460|gb|ACL85273.1| Faf-PA [synthe...
3.0E-94 [13..527] [6..463]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
1.0E-90 [19..523] [6..463]

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Predicted Domain #1
Region A:
Residues: [1-95]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPVVNHEDSE FHLSHTEEDK LNEFQVITNF PPEDLPDVVR LLRNHGWQLE PALSRYFDGE  60
   61 WKGEPDQMGE PTQTSTPMAE TLVPPALGPR PLLFT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.286 0.299 protein secretion a.1.1 Globin-like
View Download 0.308 0.187 protein secretion d.15.1 Ubiquitin-like
View Download 0.369 0.044 protein secretion a.83.1 Guanido kinase N-terminal domain
View Download 0.373 0.006 protein secretion a.118.11 Cytochrome c oxidase subunit E
View Download 0.266 N/A N/A d.15.1 Ubiquitin-like
View Download 0.265 N/A N/A a.46.1 Methionine synthase domain
View Download 0.247 N/A N/A a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.240 N/A N/A a.118.8 TPR-like
View Download 0.237 N/A N/A c.3.1 FAD/NAD(P)-binding domain
View Download 0.236 N/A N/A c.98.1 MurE/MurF N-terminal domain
View Download 0.232 N/A N/A d.34.1 DNA-binding domain of Mlu1-box binding protein MBP1

Predicted Domain #2
Region A:
Residues: [96-182]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASLPVVRPLP ANFRNDFRTI GLNGRSNTVW SMFESFSYDG NPFLFILLLI PRIINRLSAT  60
   61 IFTFFCTLLS LHSISGGGNS GKPKISK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.795 a.4.5 "Winged helix" DNA-binding domain
View Download 0.632 a.74.1 Cyclin-like
View Download 0.730 a.4.3 ARID-like
View Download 0.745 a.4.5 "Winged helix" DNA-binding domain
View Download 0.717 a.159.2 FF domain
View Download 0.555 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.497 d.58.25 Killer toxin KP6 alpha-subunit
View Download 0.455 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.447 a.3.1 Cytochrome c
View Download 0.427 a.60.13 Putative methyltransferase TM0872, insert domain
View Download 0.401 a.60.5 Barrier-to-autointegration factor, BAF
View Download 0.391 a.77.1 DEATH domain
View Download 0.380 a.74.1 Cyclin-like
View Download 0.365 a.39.1 EF-hand
View Download 0.365 a.36.1 Signal peptide-binding domain
View Download 0.356 d.58.23 Probable ACP-binding domain of malonyl-CoA ACP transacylase
View Download 0.352 a.46.1 Methionine synthase domain
View Download 0.350 a.165.1 Myosin phosphatase inhibitor 17kDa protein, CPI-17
View Download 0.349 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.333 d.64.1 eIF1-like
View Download 0.325 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.321 d.58.8 Viral DNA-binding domain
View Download 0.314 a.4.5 "Winged helix" DNA-binding domain
View Download 0.309 d.192.1 YlxR-like
View Download 0.306 a.77.1 DEATH domain
View Download 0.303 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.293 a.4.3 ARID-like
View Download 0.292 a.36.1 Signal peptide-binding domain
View Download 0.291 a.43.1 Met repressor-like
View Download 0.289 a.6.1 Putative DNA-binding domain
View Download 0.286 d.50.3 PI-Pfui intein middle domain
View Download 0.280 a.4.1 Homeodomain-like
View Download 0.274 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.274 a.5.3 N-terminal domain of phosphatidylinositol transfer protein sec14p
View Download 0.271 a.158.1 F-box domain
View Download 0.264 a.4.1 Homeodomain-like
View Download 0.264 a.77.1 DEATH domain
View Download 0.256 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.248 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.247 a.118.11 Cytochrome c oxidase subunit E
View Download 0.246 a.3.1 Cytochrome c
View Download 0.244 a.77.1 DEATH domain
View Download 0.243 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.241 a.74.1 Cyclin-like
View Download 0.239 a.3.1 Cytochrome c
View Download 0.236 a.4.11 RNA polymerase subunit RPB10
View Download 0.236 a.39.1 EF-hand
View Download 0.234 a.159.1 Protein serine/threonine phosphatase 2C, C-terminal domain
View Download 0.231 a.74.1 Cyclin-like
View Download 0.227 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.223 a.28.1 ACP-like
View Download 0.223 a.4.1 Homeodomain-like
View Download 0.221 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.220 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.219 a.144.2 Ribosomal protein L20
View Download 0.219 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.217 d.58.17 Metal-binding domain
View Download 0.216 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.215 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.215 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.214 d.54.1 Enolase N-terminal domain-like
View Download 0.211 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.208 a.74.1 Cyclin-like
View Download 0.207 a.118.8 TPR-like
View Download 0.205 a.74.1 Cyclin-like
View Download 0.204 a.77.1 DEATH domain
View Download 0.203 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.200 d.58.49 YajQ-like

Predicted Domain #3
Region A:
Residues: [183-351]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPKAPTRETH IPLAEILGDT KDKDAFCELK SFKPDISFNE ALRIAKEEFK FMLLILVGDT  60
   61 YDTDTDTVDV NSKLLLEKIL LNKKTLQYLR KIDNDLIIYL KCVHELEPWL VARQLGVRNT 120
  121 PEIFLIANVA NKASHSETLP SQRLSILGKL KVNSLNRFLQ SLTNVVEKY

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
protein disulfide isomerase activity 2.05206748531532 bayes_pls_golite062009
intramolecular oxidoreductase activity, transposing S-S bonds 2.05206748531532 bayes_pls_golite062009
intramolecular oxidoreductase activity, interconverting keto- and enol-groups 1.83987272812734 bayes_pls_golite062009
intramolecular oxidoreductase activity 1.5535855642475 bayes_pls_golite062009
catalytic activity 0.672192331361968 bayes_pls_golite062009
protein binding 0.532751276111804 bayes_pls_golite062009
hydrolase activity 0.517269321619613 bayes_pls_golite062009
binding 0.235855919597681 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 0.0866917827040035 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [352-426]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPELVVNKTE MHELRMSREI KKLQEDAYKK SLEMDRIKAI EKEKSLKHAQ DLKLNSTARQ  60
   61 LKWLKACIDE IQPFE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
small conjugating protein ligase activity 6.3238498800949 bayes_pls_golite062009
ubiquitin-protein ligase activity 5.759996473289 bayes_pls_golite062009
acid-amino acid ligase activity 5.32190918602578 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 4.23828791893907 bayes_pls_golite062009
protein binding 2.26682390101852 bayes_pls_golite062009
ligase activity 2.25858205355159 bayes_pls_golite062009
binding 1.76448263865625 bayes_pls_golite062009
hydrolase activity 0.614233748923048 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [427-518]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TTGKQATLQF RTSSGKRFVK KFPSMTTLYQ IYQSIGCHIY LAVYSSDPAE WSNALQDKIR  60
   61 QLSADDDMLC FKEGQLETAT ATTIEELGHI IN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.154902
Match: 1h8cA_
Description: Fas-assosiated factor 1, Faf1
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [519-584]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NELTSFDLER GKLEFDFELV SPFPKYTVHP NEHMSVDQVP QLWPNGSLLV EALDEEDEED  60
   61 EENEEQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.677 a.4.1 Homeodomain-like
View Download 0.671 a.60.1 SAM/Pointed domain
View Download 0.676 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.733 a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.674 a.50.1 Anaphylotoxins (complement system)
View Download 0.651 a.4.1 Homeodomain-like
View Download 0.627 a.4.1 Homeodomain-like
View Download 0.600 a.4.5 "Winged helix" DNA-binding domain
View Download 0.564 a.60.4 DNA repair protein Rad51, N-terminal domain
View Download 0.549 a.60.4 DNA repair protein Rad51, N-terminal domain
View Download 0.540 a.4.11 RNA polymerase subunit RPB10
View Download 0.525 a.60.1 SAM/Pointed domain
View Download 0.515 a.4.11 RNA polymerase subunit RPB10
View Download 0.500 a.60.1 SAM/Pointed domain
View Download 0.497 a.60.1 SAM/Pointed domain
View Download 0.489 a.60.1 SAM/Pointed domain
View Download 0.458 a.60.4 DNA repair protein Rad51, N-terminal domain
View Download 0.453 a.60.1 SAM/Pointed domain
View Download 0.430 a.60.8 HRDC-like
View Download 0.428 a.36.1 Signal peptide-binding domain
View Download 0.422 a.112.1 Description not found.
View Download 0.410 a.4.5 "Winged helix" DNA-binding domain
View Download 0.397 a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.365 a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.343 a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.342 a.36.1 Signal peptide-binding domain
View Download 0.336 a.4.5 "Winged helix" DNA-binding domain
View Download 0.332 a.36.1 Signal peptide-binding domain
View Download 0.329 a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.313 a.4.1 Homeodomain-like
View Download 0.302 a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.301 a.4.2 Methylated DNA-protein cysteine methyltransferase, C-terminal domain
View Download 0.300 a.60.1 SAM/Pointed domain
View Download 0.298 a.60.5 Barrier-to-autointegration factor, BAF
View Download 0.283 a.60.8 HRDC-like
View Download 0.242 a.4.1 Homeodomain-like
View Download 0.235 d.93.1 SH2 domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle