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View Structure Prediction Details

Protein: HSP60
Organism: Saccharomyces cerevisiae
Length: 572 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HSP60.

Description E-value Query
Range		 Subject
Range
CH65_RHIME, CH60... - (P35471) 60 kDa chaperonin 5 (Protein Cpn60 5) (groEL protein 5), 60 kDa chaperonin 5 OS=Rhizobium m...
CH605_RHIME - 60 kDa chaperonin 5 OS=Rhizobium meliloti (strain 1021) GN=groL5 PE=2 SV=2
 0.0 [23..566] [2..541]
CH602_RHILO - 60 kDa chaperonin 2 OS=Rhizobium loti (strain MAFF303099) GN=groL2 PE=3 SV=1
CH62_RHILO, CH60... - (Q98IH9) 60 kDa chaperonin 2 (Protein Cpn60 2) (groEL protein 2), 60 kDa chaperonin 2 OS=Rhizobium l...
 0.0 [23..566] [2..541]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [23..564] [2..540]
CH601_BRADU - 60 kDa chaperonin 1 OS=Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / US...
CH601_BRAJA - 60 kDa chaperonin 1 OS=Bradyrhizobium japonicum GN=groL1 PE=2 SV=3
 0.0 [23..563] [2..539]
CH601_RHOSH - 60 kDa chaperonin 1 OS=Rhodobacter sphaeroides GN=groL1 PE=1 SV=4
CH601_RHOS4 - 60 kDa chaperonin 1 OS=Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158) GN=...
gi|221638732, gi... - gi|221638732|ref|YP_002524994.1| 60 kDa chaperonin 1 [Rhodobacter sphaeroides KD131], gi|221159513|g...
 0.0 [23..556] [2..532]
CH602_RHILE - 60 kDa chaperonin 2 OS=Rhizobium leguminosarum GN=groL2 PE=3 SV=1
 0.0 [23..553] [2..529]
CH60_RHOS5 - 60 kDa chaperonin OS=Rhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3) GN=groL PE=3 SV=1
CH60_RHOPL - 60 kDa chaperonin OS=Rhodopseudomonas palustris GN=groL PE=3 SV=1
 0.0 [23..557] [2..533]
gi|12006268 - gi|12006268|gb|AAG44815.1|AF274871_2 GroEL [Geobacillus stearothermophilus]
 0.0 [24..572] [2..539]

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Predicted Domain #1
Region A:
Residues: [1-158] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRSSVVRSR ATLRPLLRRA YSSHKELKFG VEGRASLLKG VETLAEAVAA TLGPKGRNVL  60
   61 IEQPFGPPKI TKDGVTVAKS IVLKDKFENM GAKLLQEVAS KTNEAAGDGT TSATVLGRAI 120
  121 FTESVKNVAA GCNPMDLRRG SQVAVEKVIE FLSANKKE

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [429-572] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VEEGILPGGG TALVKASRVL DEVVVDNFDQ KLGVDIIRKA ITRPAKQIIE NAGEEGSVII  60
   61 GKLIDEYGDD FAKGYDASKS EYTDMLATGI IDPFKVVRSG LVDASGVASL LATTEVAIVD 120
  121 APEPPAAAGA GGMPGGMPGM PGMM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2510.0
Match: 1iokA_
Description: GroEL, E domain; GroEL, A domain; GroEL, I domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
unfolded protein binding 7.60116801069598 bayes_pls_golite062009
misfolded protein binding 2.60932901317399 bayes_pls_golite062009
lipopolysaccharide binding 2.08823822762317 bayes_pls_golite062009
binding 2.07154556649829 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 1.90846357786961 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 1.85422470116133 bayes_pls_golite062009
protein binding 1.68543685258552 bayes_pls_golite062009
nucleic acid binding 1.67284737458957 bayes_pls_golite062009
DNA binding 1.53776996197958 bayes_pls_golite062009
transporter activity 1.27879339110564 bayes_pls_golite062009
transmembrane transporter activity 1.08697283907212 bayes_pls_golite062009
chaperone binding 0.91200031047441 bayes_pls_golite062009
substrate-specific transporter activity 0.828920415160435 bayes_pls_golite062009
ATPase activity, coupled 0.787685249362834 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.75018875403424 bayes_pls_golite062009
pyrophosphatase activity 0.69634667457441 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.682843768728088 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.680378643689288 bayes_pls_golite062009
structure-specific DNA binding 0.650832159017275 bayes_pls_golite062009
ATPase activity 0.584574936611857 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.573106450426516 bayes_pls_golite062009
insulin binding 0.54263404774246 bayes_pls_golite062009
single-stranded DNA binding 0.44104272460881 bayes_pls_golite062009
catalytic activity 0.424959044318554 bayes_pls_golite062009
cell surface binding 0.326492680678891 bayes_pls_golite062009
peptide hormone binding 0.280457039468896 bayes_pls_golite062009
ion transmembrane transporter activity 0.280310103153739 bayes_pls_golite062009
active transmembrane transporter activity 0.275534581026027 bayes_pls_golite062009
primary active transmembrane transporter activity 0.252704226951294 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.243984617084631 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.205808843369749 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 0.202279803135899 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 0.20198255686005 bayes_pls_golite062009
cation transmembrane transporter activity 0.0778814959589007 bayes_pls_golite062009
hydrolase activity 0.0491351110520448 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [159-428] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ITTSEEIAQV ATISANGDSH VGKLLASAME KVGKEGVITI REGRTLEDEL EVTEGMRFDR  60
   61 GFISPYFITD PKSSKVEFEK PLLLLSEKKI SSIQDILPAL EISNQSRRPL LIIAEDVDGE 120
  121 ALAACILNKL RGQVKVCAVK APGFGDNRKN TIGDIAVLTG GTVFTEELDL KPEQCTIENL 180
  181 GSCDSITVTK EDTVILNGSG PKEAIQERIE QIKGSIDITT TNSYEKEKLQ ERLAKLSGGV 240
  241 AVIRVGGASE VEVGEKKDRY DDALNATRAA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2510.0
Match: 1iokA_
Description: GroEL, E domain; GroEL, A domain; GroEL, I domain
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle