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View Structure Prediction Details

Protein: ACE2
Organism: Saccharomyces cerevisiae
Length: 770 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ACE2.

Description E-value Query
Range
Subject
Range
ZNF347 - zinc finger protein 347
gi|208968133 - gi|208968133|dbj|BAG73905.1| zinc finger protein 347 [synthetic construct]
0.0 [38..770] [27..786]
ZN252_CANLF - Zinc finger protein 252 OS=Canis lupus familiaris GN=ZNF252 PE=2 SV=1
0.0 [38..769] [34..840]

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Predicted Domain #1
Region A:
Residues: [1-101]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDNVVDPWYI NPSGFAKDTQ DEEYVQHHDN VNPTIPPPDN YILNNENDDG LDNLLGMDYY  60
   61 NIDDLLTQEL RDLDIPLVPS PKTGDGSSDK KNIDRTWNLG D

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [102-170]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENNKVSHYSK KSMSSHKRGL SGTAIFGFLG HNKTLSISSL QQSILNMSKD PQPMELINEL  60
   61 GNHNTVKNN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [171-338]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDDFDHIREN DGENSYLSQV LLKQQEELRI ALEKQKEVNE KLEKQLRDNQ IQQEKLRKVL  60
   61 EEQEEVAQKL VSGATNSNSK PGSPVILKTP AMQNGRMKDN AIIVTTNSAN GGYQFPPPTL 120
  121 ISPRMSNTSI NGSPSRKYHR QRYPNKSPES NGLNLFSSNS GYLRDSEL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [339-397]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSFSPQNYNL NLDGLTYNDH NNTSDKNNND KKNSTGDNIF RLFEKTSPGG LSISPRING

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 109.190949
Match: 1lu6A_
Description: No description for 1lu6A_ was found.

Predicted Domain #5
Region A:
Residues: [398-459]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSLRSPFLVG TDKSRDDRYA AGTFTPRTQL SPIHKKRESV VSTVSTISQL QDDTEPIHMR  60
   61 NT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 109.190949
Match: 1lu6A_
Description: No description for 1lu6A_ was found.

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22082323675675 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
transcription activator activity 2.19952417915035 bayes_pls_golite062009
chromatin binding 2.18464662431232 bayes_pls_golite062009
transcription repressor activity 1.64349785387632 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.63161912031789 bayes_pls_golite062009
sequence-specific DNA binding 1.42975942698743 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
protein binding 1.00484935878505 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009
transcription corepressor activity 0.10558148421807 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [460-544]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QNPTLRNANA LASSSVLPPI PGSSNNTPIK NSLPQKHVFQ HTPVKAPPKN GSNLAPLLNA  60
   61 PDLTDHQLEI KTPIRNNSHC EVESY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [545-636]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PQVPPVTHDI HKSPTLHSTS PLPDEIIPRT TPMKITKKPT TLPPGTIDQY VKELPDKLFE  60
   61 CLYPNCNKVF KRRYNIRSHI QTHLQDRPYS CD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 113.69897
Match: 1ubdC_
Description: Ying-yang 1 (yy1, zinc finger domain)
Matching Structure (courtesy of the PDB):

Predicted Domain #8
Region A:
Residues: [637-718]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FPGCTKAFVR NHDLIRHKIS HNAKKYICPC GKRFNREDAL MVHRSRMICT GGKKLEHSIN  60
   61 KKLTSPKKSL LDSPHDTSPV KE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [719-770]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TIARDKDGSV LMKMEEQLRD DMRKHGLLDP PPSTAAHEQN SNRTLSNETD AL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.502279
Match: 2adr__
Description: ADR1
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle