| Protein: | ACE2 |
| Organism: | Saccharomyces cerevisiae |
| Length: | 770 amino acids |
| Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ACE2.
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [38..770] | [27..786] |
|
|
0.0 | [38..769] | [34..840] |
|
Region A: Residues: [1-101] |
1 11 21 31 41 51
| | | | | |
1 MDNVVDPWYI NPSGFAKDTQ DEEYVQHHDN VNPTIPPPDN YILNNENDDG LDNLLGMDYY 60
61 NIDDLLTQEL RDLDIPLVPS PKTGDGSSDK KNIDRTWNLG D
|
| Detection Method: |  |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
| MCM Score |
GO Score |
GO Term |
SCOP Match |
SCOP Description | ||
| View | Download | 0.228 | 0.104 | regulation of transcription involved in G1 phase of mitotic cell cycle | d.26.1 | FKBP-like |
| View | Download | 0.212 | 0.061 | regulation of transcription involved in G1 phase of mitotic cell cycle | a.100.1 | 6-phosphogluconate dehydrogenase C-terminal domain-like |
| View | Download | 0.228 | 0.012 | transcription activator activity | d.26.1 | FKBP-like |
| View | Download | 0.212 | 0.007 | transcription activator activity | a.100.1 | 6-phosphogluconate dehydrogenase C-terminal domain-like |
|
Region A: Residues: [102-170] |
1 11 21 31 41 51
| | | | | |
1 ENNKVSHYSK KSMSSHKRGL SGTAIFGFLG HNKTLSISSL QQSILNMSKD PQPMELINEL 60
61 GNHNTVKNN
|
| Detection Method: | |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
| MCM Score |
SCOP Match |
SCOP Description | ||
| View | Download | 0.475 | a.4.1 | Homeodomain-like |
| View | Download | 0.470 | a.60.1 | SAM/Pointed domain |
| View | Download | 0.775 | a.36.1 | Signal peptide-binding domain |
| View | Download | 0.453 | a.50.1 | Anaphylotoxins (complement system) |
| View | Download | 0.445 | a.48.3 | Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 |
| View | Download | 0.433 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.433 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.432 | a.60.5 | Barrier-to-autointegration factor, BAF |
| View | Download | 0.390 | a.60.11 | Hypothetical protein YjbJ |
| View | Download | 0.368 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.363 | a.4.1 | Homeodomain-like |
| View | Download | 0.358 | a.60.13 | Putative methyltransferase TM0872, insert domain |
| View | Download | 0.350 | a.4.1 | Homeodomain-like |
| View | Download | 0.347 | a.159.2 | FF domain |
| View | Download | 0.344 | a.60.4 | DNA repair protein Rad51, N-terminal domain |
| View | Download | 0.340 | a.60.9 | lambda integrase-like, N-terminal domain |
| View | Download | 0.337 | a.52.1 | Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin |
| View | Download | 0.335 | a.60.3 | C-terminal domain of RNA polymerase alpha subunit |
| View | Download | 0.328 | a.60.1 | SAM/Pointed domain |
| View | Download | 0.312 | a.60.12 | DNA polymerase beta-like, second domain |
| View | Download | 0.311 | a.60.2 | RuvA domain 2-like |
| View | Download | 0.308 | a.156.1 | S13-like H2TH domain |
| View | Download | 0.291 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.288 | a.8.1 | Bacterial immunoglobulin/albumin-binding domains |
| View | Download | 0.287 | a.60.2 | RuvA domain 2-like |
| View | Download | 0.286 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.261 | a.4.9 | Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 |
| View | Download | 0.260 | a.4.3 | ARID-like |
| View | Download | 0.233 | a.4.1 | Homeodomain-like |
| View | Download | 0.232 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.228 | a.65.1 | Annexin |
| View | Download | 0.228 | a.159.1 | Protein serine/threonine phosphatase 2C, C-terminal domain |
| View | Download | 0.219 | a.46.2 | Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain |
| View | Download | 0.219 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.211 | a.163.1 | Crustacean CHH/MIH/GIH neurohormone |
|
Region A: Residues: [171-338] |
1 11 21 31 41 51
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1 NDDFDHIREN DGENSYLSQV LLKQQEELRI ALEKQKEVNE KLEKQLRDNQ IQQEKLRKVL 60
61 EEQEEVAQKL VSGATNSNSK PGSPVILKTP AMQNGRMKDN AIIVTTNSAN GGYQFPPPTL 120
121 ISPRMSNTSI NGSPSRKYHR QRYPNKSPES NGLNLFSSNS GYLRDSEL
|
| Detection Method: | |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
|
Region A: Residues: [339-397] |
1 11 21 31 41 51
| | | | | |
1 LSFSPQNYNL NLDGLTYNDH NNTSDKNNND KKNSTGDNIF RLFEKTSPGG LSISPRING
|
| Detection Method: | |
| Confidence: | 109.190949 |
| Match: | 1lu6A_ |
| Description: | No description for 1lu6A_ was found. |
|
Region A: Residues: [398-459] |
1 11 21 31 41 51
| | | | | |
1 NSLRSPFLVG TDKSRDDRYA AGTFTPRTQL SPIHKKRESV VSTVSTISQL QDDTEPIHMR 60
61 NT
|
| Detection Method: | |
| Confidence: | 109.190949 |
| Match: | 1lu6A_ |
| Description: | No description for 1lu6A_ was found. |
| Term | Confidence | Notes |
| transcription regulator activity | 4.70988788192472 | bayes_pls_golite062009 |
| nucleic acid binding | 4.58713908116892 | bayes_pls_golite062009 |
| DNA binding | 4.56219307357342 | bayes_pls_golite062009 |
| transcription factor activity | 3.50954949535763 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 3.22082323675675 | bayes_pls_golite062009 |
| binding | 3.10743787485868 | bayes_pls_golite062009 |
| transcription activator activity | 2.19952417915035 | bayes_pls_golite062009 |
| chromatin binding | 2.18464662431232 | bayes_pls_golite062009 |
| transcription repressor activity | 1.64349785387632 | bayes_pls_golite062009 |
| specific RNA polymerase II transcription factor activity | 1.63161912031789 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 1.42975942698743 | bayes_pls_golite062009 |
| transcription factor binding | 1.39608963544799 | bayes_pls_golite062009 |
| protein binding | 1.00484935878505 | bayes_pls_golite062009 |
| transcription cofactor activity | 0.77874411480713 | bayes_pls_golite062009 |
| catalytic activity | 0.245893663605433 | bayes_pls_golite062009 |
| transcription corepressor activity | 0.10558148421807 | bayes_pls_golite062009 |
|
Region A: Residues: [460-544] |
1 11 21 31 41 51
| | | | | |
1 QNPTLRNANA LASSSVLPPI PGSSNNTPIK NSLPQKHVFQ HTPVKAPPKN GSNLAPLLNA 60
61 PDLTDHQLEI KTPIRNNSHC EVESY
|
| Detection Method: | |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
| MCM Score |
SCOP Match |
SCOP Description | ||
| View | Download | 0.363 | c.47.1 | Thioredoxin-like |
| View | Download | 0.503 | a.3.1 | Cytochrome c |
| View | Download | 0.445 | a.35.1 | lambda repressor-like DNA-binding domains |
| View | Download | 0.238 | d.26.1 | FKBP-like |
| View | Download | 0.219 | c.51.1 | Anticodon-binding domain of Class II aaRS |
|
Region A: Residues: [545-636] |
1 11 21 31 41 51
| | | | | |
1 PQVPPVTHDI HKSPTLHSTS PLPDEIIPRT TPMKITKKPT TLPPGTIDQY VKELPDKLFE 60
61 CLYPNCNKVF KRRYNIRSHI QTHLQDRPYS CD
|
| Detection Method: | |
| Confidence: | 113.69897 |
| Match: | 1ubdC_ |
| Description: | Ying-yang 1 (yy1, zinc finger domain) |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [637-718] |
1 11 21 31 41 51
| | | | | |
1 FPGCTKAFVR NHDLIRHKIS HNAKKYICPC GKRFNREDAL MVHRSRMICT GGKKLEHSIN 60
61 KKLTSPKKSL LDSPHDTSPV KE
|
| Detection Method: | |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
| MCM Score |
GO Score |
GO Term |
SCOP Match |
SCOP Description | ||
| View | Download | 0.209 | 0.035 | regulation of transcription involved in G1 phase of mitotic cell cycle | c.51.1 | Anticodon-binding domain of Class II aaRS |
|
Region A: Residues: [719-770] |
1 11 21 31 41 51
| | | | | |
1 TIARDKDGSV LMKMEEQLRD DMRKHGLLDP PPSTAAHEQN SNRTLSNETD AL
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| Detection Method: | |
| Confidence: | 41.502279 |
| Match: | 2adr__ |
| Description: | ADR1 |
Matching Structure (courtesy of the PDB): |
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