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View Structure Prediction Details

Protein: NOC3
Organism: Saccharomyces cerevisiae
Length: 663 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NOC3.

Description E-value Query
Range
Subject
Range
NOC3_YEAST - Nucleolar complex-associated protein 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=N...
gi|207343223 - gi|207343223|gb|EDZ70751.1| YLR002Cp-like protein [Saccharomyces cerevisiae AWRI1631]
NOC3 - Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate th...
gi|151941170 - gi|151941170|gb|EDN59548.1| nucleolar complex subunit [Saccharomyces cerevisiae YJM789]
0.0 [1..663] [1..663]
NOC3L_MOUSE - Nucleolar complex protein 3 homolog OS=Mus musculus GN=Noc3l PE=2 SV=1
0.0 [4..657] [68..713]
NOC3L_CRIGR - Nucleolar complex protein 3 homolog OS=Cricetulus griseus GN=NOC3L PE=2 SV=1
0.0 [4..657] [68..714]
noc3 - Noc2p-Noc3p complex subunit Noc3
NOC3_SCHPO - Nucleolar complex-associated protein 3 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=noc...
0.0 [39..655] [121..742]
CE29708 - status:Partially_confirmed UniProt:P91136 protein_id:AAB42369.3
0.0 [22..657] [88..706]
gi|10434534 - gi|10434534|dbj|BAB14291.1| unnamed protein product [Homo sapiens]
0.0 [286..657] [4..345]
gi|18086412 - gi|18086412|gb|AAL57663.1| At2g17250/T23A1.11 [Arabidopsis thaliana]
5.0E-93 [128..663] [4..516]

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Predicted Domain #1
Region A:
Residues: [1-111]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKRNRSQFR IQERTAKKRK HEDSLLEGNV FQNAPEDMDE NTIYSAKGSS WDEEEQDYEM  60
   61 VPRKNRSDTS NLVEGLPIKV NGKVERKLHK AQEKPKDDDE EDEDSNDSSE D

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.212 a.18.1 T4 endonuclease V

Predicted functions:

Term Confidence Notes
RNA binding 3.36069436734718 bayes_pls_golite062009
binding 2.36800795249393 bayes_pls_golite062009
nucleic acid binding 1.67566088591721 bayes_pls_golite062009
structural molecule activity 1.49650156618775 bayes_pls_golite062009
protein binding 1.3800948965226 bayes_pls_golite062009
mRNA binding 1.35186555044783 bayes_pls_golite062009
transcription regulator activity 1.08645493064764 bayes_pls_golite062009
DNA binding 0.806448013051712 bayes_pls_golite062009
transcription factor activity 0.371244009721798 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [112-263]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DEGPNEEQEA EAKEDEPDTE EKILQLKEDI ADLVTKVMEE PEENTAALGR LCKMVESKNP  60
   61 NTCKFSMLAL VPVFKSIIPG YRIRPLTETE KKEKVSKEVS KLRNFEQALV YNYKNYVGRL 120
  121 QSLSKTPSNA APIQVSLGIL ATQAAKELIS TA

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.86
Match: 1b3uA
Description: Constant regulatory domain of protein phosphatase 2a, pr65alpha
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [264-329]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SHFNFRTDIF TLLLRRICKP RISTDPTSIQ IIQTFETLLN EDEEGSISFE ILRIFNKILK  60
   61 TRNFNI

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.86
Match: 1b3uA
Description: Constant regulatory domain of protein phosphatase 2a, pr65alpha
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [330-470]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EESVLNMLLS LDVLHDYDPN TKLKGNVSAP KLKKKDRVHL SKKQRKARKE MQQIEEEMRN  60
   61 AEQAVSAEER ERNQSEILKI VFTIYLNILK NNAKTLIGSV LEGLTKFGNM ANFDLLGDFL 120
  121 EVMKELISDT EFDNLSSAEV R

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.86
Match: 1b3uA
Description: Constant regulatory domain of protein phosphatase 2a, pr65alpha
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [471-663]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KALLCIVSAF SLISNTQYMK VNVDLSKFVD GLYALLPYIC LDADIELSYR SLRLADPLNN  60
   61 EIIKPSVNVS TKAELLLKAL DHVFFRSKSG TKERATAFTK RLYMCISHTP EKTSIAILKF 120
  121 IDKLMNRYPE ISGLYSSEDR IGNGHFIMEA DNPSRSNPEA ATLWDNALLE KHYCPVVTKG 180
  181 LRSLSSRSKE CSK

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.86
Match: 1b3uA
Description: Constant regulatory domain of protein phosphatase 2a, pr65alpha
Matching Structure (courtesy of the PDB):

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