YRC Public Data Repository - Protein Structure Prediction

Protein:	YLL058W
Organism:	Saccharomyces cerevisiae
Length:	575 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YLL058W.

Description	E-value	Query Range	Subject Range
YLL058W - Putative protein of unknown function with similarity to Str2p, which is a cystathionine gamma-syntha... METW_YEAST - Putative cystathionine gamma-synthase YLL058W OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288...	0.0	[1..575]	[1..575]
METB_HELPY - Cystathionine gamma-synthase OS=Helicobacter pylori (strain ATCC 700392 / 26695) GN=metB PE=1 SV=1 METB_HELPY - Cystathionine gamma-synthase OS=Helicobacter pylori GN=metB PE=3 SV=1	0.0	[158..568]	[3..380]
gi\|9946254, gi\|1... - gi\|9946254\|gb\|AAG03789.1\|AE004477_6 probable cystathionine gamma-lyase [Pseudomonas aeruginosa PAO1]... gi\|11351204 - pir\|\|F83595 probable cystathionine gamma-lyase PA0400 [imported] - Pseudomonas aeruginosa (strain PA... gi\|218889142, gi... - gi\|218889142\|ref\|YP_002438006.1\| putative cystathionine gamma-lyase [Pseudomonas aeruginosa LESB58],...	0.0	[139..567]	[1..394]
MEGL_FUSNN - L-methionine gamma-lyase OS=Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130...	0.0	[155..567]	[10..395]
METC_LACLM - Cystathionine beta-lyase OS=Lactococcus lactis subsp. cremoris (strain MG1363) GN=metC PE=1 SV=1 METC_LACLA - Cystathionine beta-lyase OS=Lactococcus lactis subsp. lactis GN=metC PE=3 SV=1 METC_LACLC - Cystathionine beta-lyase (EC 4.4.1.8) (CBL) (Beta-cystathionase) (Cysteine lyase) - Lactococcus lact... METC_LACLA - Cystathionine beta-lyase OS=Lactococcus lactis subsp. lactis (strain IL1403) GN=metC PE=3 SV=1	0.0	[156..566]	[2..379]
met3 (reserved) - cystathionine gamma-synthase MET7_SCHPO - Probable cystathionine gamma-synthase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPBC...	0.0	[5..564]	[14..609]
gi\|188993147, gi... - gi\|188993147\|ref\|YP_001905157.1\| Cys/Met metabolism PLP-dependent enzyme [Xanthomonas campestris pv....	0.0	[151..570]	[10..399]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[148..564]	[3..389]
gi\|7437091 - pir\|\|D71973 probable cystathionine gamma-synthase - Helicobacter pylori (strain J99) METB_HELPJ - Cystathionine gamma-synthase OS=Helicobacter pylori (strain J99 / ATCC 700824) GN=metB PE=3 SV=1	0.0	[158..567]	[3..379]
gi\|13699175, gi\|... - gi\|51261011\|gb\|AAH78869.1\| Cystathionase (cystathionine gamma-lyase) [Rattus norvegicus], gi\|1403106...	0.0	[158..569]	[17..398]

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Predicted Domain #1

Region A:
Residues: [1-95]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTEIEFGQPL PSNLDYAVSF GIPTWDSAIG YAEKVPEVIG KMATGYPRYF PQPPVQRLCA  60
   61 YFVKKFGRGS ENCRPFPSVN LGLKCFEYVK SVSGP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [96-433]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESKAHLEVET VTIKNRGAKT SKEPAELVLT IAAVLASEEE FETVKEYWKL RGECVSSRLA  60
   61 LSVNQLLDCA NHGSEQVLRE LEAGVFAAKK GEEKAKNLIK GRIVENRFRP FGLEKKTPNW 120
  121 EGLNLNPNED VYLVSSGMSA ISTARNLLTF WEEKKNSGDS LNKTTSDQKK KPLLCDTVGI 180
  181 FGFPFKDTQV IMTKFGKCKF FGFGNSRDVV ELQKFLETSK QRILAVFVET PSNPLLNMPD 240
  241 LKKLRSLADQ YGFFIVIDDT IGGLNVDILP YADIVSTSLT KLFNGASNVM GGSVVLNPKS 300
  301 SLYPYAREYF RSANFEDLLW CEDAIVLERN SRDFEDRT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	208.228787
Match:	1gc0A_
Description:	Methionine gamma-lyase, MGL
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	2.29878871754893	bayes_pls_golite062009
L-aspartate:2-oxoglutarate aminotransferase activity	1.87460342369605	bayes_pls_golite062009
glycine dehydrogenase (decarboxylating) activity	1.80372125032222	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor	1.80372125032222	bayes_pls_golite062009
transferase activity	1.44093490824786	bayes_pls_golite062009
transferase activity, transferring nitrogenous groups	1.28316822767388	bayes_pls_golite062009
transaminase activity	1.24990480711889	bayes_pls_golite062009
carbon-sulfur lyase activity	0.698312655247044	bayes_pls_golite062009
cystathionine beta-lyase activity	0.6849039330512	bayes_pls_golite062009
binding	0.536634592992536	bayes_pls_golite062009
cystathionine gamma-lyase activity	0.505859361763689	bayes_pls_golite062009
glycine hydroxymethyltransferase activity	0.271623203801431	bayes_pls_golite062009
O-phospho-L-serine:2-oxoglutarate aminotransferase activity	0.234399054481664	bayes_pls_golite062009
pyridoxal phosphate binding	0.16957228630576	bayes_pls_golite062009
vitamin B6 binding	0.16957228630576	bayes_pls_golite062009
adenosylmethionine-8-amino-7-oxononanoate transaminase activity	0.0669652799570574	bayes_pls_golite062009
nucleic acid binding	0.013097682076602	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [434-575]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LRANANTGIL LNDLLLPEEG KICKKIYYPT VTSKETFENY ESVRNERGGY GCLFSVAFFN  60
   61 EGDAKAFYDS LKVFKGPSNG TNFTLACPYV HLAHHSELEE VSKFGADPNI IRVSVGLEDI 120
  121 QWLLKVFSSA LDVVKSRGSK HS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	208.228787
Match:	1gc0A_
Description:	Methionine gamma-lyase, MGL
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: