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View Structure Prediction Details

Protein: ASH1
Organism: Saccharomyces cerevisiae
Length: 588 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ASH1.

Description E-value Query
Range
Subject
Range
ASH1_YEAST - Transcriptional regulatory protein ASH1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=...
ASH1 - Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of ana...
0.0 [1..588] [1..588]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
1.0E-52 [220..563] [361..728]
AREA_EMENI - Nitrogen regulatory protein areA OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / ...
AREA_EMENI - Nitrogen regulatory protein areA OS=Emericella nidulans GN=areA PE=1 SV=2
3.0E-52 [220..563] [361..728]
GAT5B_XENLA - GATA-binding factor 5-B OS=Xenopus laevis GN=gata5-b PE=2 SV=1
3.0E-42 [330..580] [9..263]
AREA_ASPNG - Nitrogen regulatory protein areA OS=Aspergillus niger GN=areA PE=3 SV=1
2.0E-41 [220..563] [366..731]
gi|12802699 - gi|12802699|gb|AAK08066.1|AF320305_1 AreA [Aspergillus oryzae]
6.0E-39 [220..563] [342..707]
GATA3_MOUSE - Trans-acting T-cell-specific transcription factor GATA-3 OS=Mus musculus GN=Gata3 PE=1 SV=1
5.0E-38 [308..580] [30..342]

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Predicted Domain #1
Region A:
Residues: [1-236]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSLYIKTPL HALSAGPDSH ANSSYYDNLL LPSFSNLSSN ISRNNITTDN NINSASPRKY  60
   61 SFHSLNVSPI LSPISLANEI LGKKSNTAPA SPHHMDYNPI SSLTPGNSPE FNKASLSQIS 120
  121 FTNPLNYGSG LGFSSNSQPR LPLLDRLSSV SLSKRPERPQ QSLPSLRHLQ LLPSPLLQEN 180
  181 AARFPDTSKR TSNWKTDLTH WCKDTNYQDY VKIREEVAHF KPLSIPNLTN NQNNDS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [237-475]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FNYGKELEST RSSKFHSPSK ESFDRTKLIP SILEAKDQFK DLSNNAWSIT PPVTPPMSPP  60
   61 TNRTMERTTL RGVEASFFEG KSSNNDSIFN PIISEKLVQE VKHQRQLRGN SFPMPNASHK 120
  121 KTNSFKALQI KKLLANRDIL SNNSKSNVRK PSKNKISKQA SNVFGNTARQ LVMKLDNASY 180
  181 SSVSASSSPS PSTPTKSGKM RSRSSSPVRP KAYTPSPRSP NYHRFALDSP PQSPRRSSN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [476-588]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSITKKGSRR SSGSSPTRHT TRVCVSCHSS DSPCWRPSWS PRKQDQLCNS CGLRYKKTHT  60
   61 RCLNDLCRKI PTKGEINIMK SNGIDKEFVP ERNCEIEGYR CLFCNYITET VEN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.221849
Match: 4gatA_
Description: Erythroid transcription factor GATA-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.00967542385368 bayes_pls_golite062009
DNA binding 3.60745514727532 bayes_pls_golite062009
nucleic acid binding 3.47256374293954 bayes_pls_golite062009
binding 2.96409924710655 bayes_pls_golite062009
transcription factor activity 2.90769972671972 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 2.55186574506963 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.40923942043513 bayes_pls_golite062009
transcription repressor activity 1.88834375049208 bayes_pls_golite062009
sequence-specific DNA binding 1.62841402245495 bayes_pls_golite062009
transcription activator activity 1.62405765585032 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 1.49515149729803 bayes_pls_golite062009
protein binding 1.39455913713025 bayes_pls_golite062009
transcription factor binding 1.38523780690867 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.26452462867497 bayes_pls_golite062009
structural constituent of ribosome 1.14370842685155 bayes_pls_golite062009
structural molecule activity 1.03433454627943 bayes_pls_golite062009
transcription coactivator activity 0.61572149323953 bayes_pls_golite062009
transcription cofactor activity 0.58115018700114 bayes_pls_golite062009
cytoskeletal protein binding 0.405267736307896 bayes_pls_golite062009
catalytic activity 0.101795606736461 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle