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View Structure Prediction Details

Protein: HOM6
Organism: Saccharomyces cerevisiae
Length: 359 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HOM6.

Description E-value Query
Range
Subject
Range
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
3.0E-91 [1..359] [553..912]
AKH1_MAIZE - Bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic OS=Zea mays GN=AKHSDH1 PE=2 SV=...
3.0E-88 [1..359] [557..916]
AKH_DAUCA - Bifunctional aspartokinase/homoserine dehydrogenase, chloroplastic (Fragment) OS=Daucus carota PE=1 ...
5.0E-85 [1..359] [558..917]
gi|151945204 - gi|151945204|gb|EDN63455.1| L-homoserine:NADP oxidoreductase [Saccharomyces cerevisiae YJM789]
gi|190409609 - gi|190409609|gb|EDV12874.1| L-homoserine:NADP oxidoreductase [Saccharomyces cerevisiae RM11-1a]
DHOM_YEAST - Homoserine dehydrogenase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HOM6 PE=1 SV=1
HOM6 - Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third...
3.0E-81 [1..359] [1..359]
AKH1_ARATH - Bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic OS=Arabidopsis thaliana GN=AKHS...
2.0E-79 [1..359] [548..907]

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Predicted Domain #1
Region A:
Residues: [1-144]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTKVVNVAV IGAGVVGSAF LDQLLAMKST ITYNLVLLAE AERSLISKDF SPLNVGSDWK  60
   61 AALAASTTKT LPLDDLIAHL KTSPKPVILV DNTSSAYIAG FYTKFVENGI SIATPNKKAF 120
  121 SSDLATWKAL FSNKPTNGFV YHEA

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [341-359]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AAVTAAGVLG DVIKIAQRL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10080.69897
Match: 1ebfA_
Description: Homoserine dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 2.54843319568228 bayes_pls_golite062009
transcription regulator activity 1.90939908578582 bayes_pls_golite062009
oxidoreductase activity 1.84451425136793 bayes_pls_golite062009
DNA binding 1.61355789916908 bayes_pls_golite062009
nucleic acid binding 1.48478425318425 bayes_pls_golite062009
binding 1.22114607236074 bayes_pls_golite062009
transcription factor activity 0.91090893050278 bayes_pls_golite062009
phosphoglycerate dehydrogenase activity 0.639509916626856 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.610531769148819 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 0.610013758225609 bayes_pls_golite062009
structural molecule activity 0.160242197882814 bayes_pls_golite062009
N-acetyl-gamma-glutamyl-phosphate reductase activity 0.0651785123513661 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [145-340]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TVGAGLPIIS FLREIIQTGD EVEKIEGIFS GTLSYIFNEF STSQANDVKF SDVVKVAKKL  60
   61 GYTEPDPRDD LNGLDVARKV TIVGRISGVE VESPTSFPVQ SLIPKPLESV KSADEFLEKL 120
  121 SDYDKDLTQL KKEAATENKV LRFIGKVDVA TKSVSVGIEK YDYSHPFASL KGSDNVISIK 180
  181 TKRYTNPVVI QGAGAG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10080.69897
Match: 1ebfA_
Description: Homoserine dehydrogenase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle