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View Structure Prediction Details

Protein: HUL4
Organism: Saccharomyces cerevisiae
Length: 892 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HUL4.

Description E-value Query
Range
Subject
Range
HUL4_YEAST - Probable E3 ubiquitin-protein ligase HUL4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) G...
HUL4 - Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability
0.0 [1..892] [1..892]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [208..890] [224..872]
gi|19718764, gi|... - gi|19718764|ref|NP_570854.1| ubiquitin protein ligase E3A isoform 3 [Homo sapiens], gi|158258465|dbj...
gi|114655961, gi... - gi|114655961|ref|XP_001161311.1| PREDICTED: ubiquitin protein ligase E3A isoform 12 [Pan troglodytes...
0.0 [208..890] [231..870]
ptr1 - HECT domain
PTR1_SCHPO - E3 ubiquitin-protein ligase ptr1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ptr1 PE=1...
0.0 [109..891] [2421..3226]
UE3A_MOUSE, UBE3... - (O08759) Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein-associated protein E6-AP), Ubi...
0.0 [208..890] [245..883]

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Predicted Domain #1
Region A:
Residues: [1-448]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVSLFDKLNA KKDGRDGSVS KELLSHSVAH TKNRLPKSGR RTSERSLAAS VKDGSCSNSK  60
   61 SNKRNSSASV SGEEDKSCLI SLNCLCCGVP LRFPASITKF RCSACQVTVI VKEPEINSNL 120
  121 ESSTHISCTL EGLQMVVRRC HDDLQRLKKT GILDKERKGL IFQPVITYLL DRFHDVSILN 180
  181 RSFLVHDGGK NIKMLNYEVL QRFYSILSNL PTRKPYYSML CCCNDLLKRI TINKGENLQI 240
  241 LQYRWLLIIL NIPTIRTCLI RDRKSKNVFE TQQIRAVSYE LAKRCIGYLS NLSTKTSQQL 300
  301 IQSLRRTPTD NFSYQVEILN LYINFQFSRL LSNELSNRTA KNNVKPEDEM RSRLRRHHTT 360
  361 GHEFLSTRPI SAQSNDKQGS GFTHPVNNKM KFKFFQYEED WHIHSAAKLT FIYYVANTRR 420
  421 NGRGALSIQS FYNITLDFID YKQDFDHW

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [449-559]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RGVAQKTKMN QLIEEWGNST TKKCFSFCKY PFILSLGIKI SIMEYEIRRI MEHEAEQAFL  60
   61 ISLDKGKSVD VYFKIKVRRD VISHDSLRCI KEHQGDLLKS LRIEFVNEPG I

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 710.0103
Match: 1c4zA_
Description: Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap)
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [560-662]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DAGGLRKEWF FLLTKSLFNP MNGLFIYIKE SSRSWFAIDP PNFDKSKGKN SQLELYYLFG  60
   61 VVMGLAIFNS TILDLQFPKA LYKKLCSEPL SFEDYSELFP ETS

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [731-774]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VEFYLEKSIE PQYNKFVSGF KRVFAECNSI KLFNSEELER LVCG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 710.0103
Match: 1c4zA_
Description: Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap)
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [663-730]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RNLIKMLNYT EDNFEDVFSL TFETTYRNNN WILNDSKSSK EYVTVELCEN GRNVPITQSN  60
   61 KHEFVMKW

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [775-892]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DEEQTKFDFK SLRSVTKYVG GFSDDSRAVC WFWEIIESWD YPLQKKLLQF VTASDRIPAT  60
   61 GISTIPFKIS LLGSHDSDDL PLAHTCFNEI CLWNYSSKKK LELKLLWAIN ESEGYGFR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 710.0103
Match: 1c4zA_
Description: Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap)
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [509-892]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISLDKGKSVD VYFKIKVRRD VISHDSLRCI KEHQGDLLKS LRIEFVNEPG IDAGGLRKEW  60
   61 FFLLTKSLFN PMNGLFIYIK ESSRSWFAID PPNFDKSKGK NSQLELYYLF GVVMGLAIFN 120
  121 STILDLQFPK ALYKKLCSEP LSFEDYSELF PETSRNLIKM LNYTEDNFED VFSLTFETTY 180
  181 RNNNWILNDS KSSKEYVTVE LCENGRNVPI TQSNKHEFVM KWVEFYLEKS IEPQYNKFVS 240
  241 GFKRVFAECN SIKLFNSEEL ERLVCGDEEQ TKFDFKSLRS VTKYVGGFSD DSRAVCWFWE 300
  301 IIESWDYPLQ KKLLQFVTAS DRIPATGIST IPFKISLLGS HDSDDLPLAH TCFNEICLWN 360
  361 YSSKKKLELK LLWAINESEG YGFR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 122.0
Match: 1c4zA
Description: Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 7.14616396317218 bayes_pls_golite062009
small conjugating protein ligase activity 6.99796579811325 bayes_pls_golite062009
acid-amino acid ligase activity 6.03005793772151 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 4.50502148129705 bayes_pls_golite062009
sodium channel inhibitor activity 3.64966529121446 bayes_pls_golite062009
proline-rich region binding 3.26053533977534 bayes_pls_golite062009
phosphothreonine binding 2.3451206920409 bayes_pls_golite062009
phosphoserine binding 2.3451206920409 bayes_pls_golite062009
binding 2.32045312021486 bayes_pls_golite062009
ion channel inhibitor activity 2.14402963004533 bayes_pls_golite062009
channel inhibitor activity 2.14402963004533 bayes_pls_golite062009
RNA polymerase binding 1.8762146737407 bayes_pls_golite062009
ligase activity 1.85936914071714 bayes_pls_golite062009
protein binding 1.29390544644063 bayes_pls_golite062009
sodium channel regulator activity 1.19047973745862 bayes_pls_golite062009
catalytic activity 1.15152367676155 bayes_pls_golite062009
transcription factor binding 0.585725073778084 bayes_pls_golite062009
nucleic acid binding 0.509776214744915 bayes_pls_golite062009
transcription regulator activity 0.376852535152545 bayes_pls_golite062009
ubiquitin-ubiquitin ligase activity 0.373649200425601 bayes_pls_golite062009
DNA binding 0.187697131456126 bayes_pls_golite062009
channel regulator activity 0.072778668515899 bayes_pls_golite062009
0.051942165438844 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle