Protein: | HUL4 |
Organism: | Saccharomyces cerevisiae |
Length: | 892 amino acids |
Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HUL4.
Description | E-value | Query Range |
Subject Range |
|
0.0 | [1..892] | [1..892] |
|
0.0 | [208..890] | [224..872] |
|
0.0 | [208..890] | [231..870] |
|
0.0 | [109..891] | [2421..3226] |
|
0.0 | [208..890] | [245..883] |
Region A: Residues: [1-448] |
1 11 21 31 41 51 | | | | | | 1 MVSLFDKLNA KKDGRDGSVS KELLSHSVAH TKNRLPKSGR RTSERSLAAS VKDGSCSNSK 60 61 SNKRNSSASV SGEEDKSCLI SLNCLCCGVP LRFPASITKF RCSACQVTVI VKEPEINSNL 120 121 ESSTHISCTL EGLQMVVRRC HDDLQRLKKT GILDKERKGL IFQPVITYLL DRFHDVSILN 180 181 RSFLVHDGGK NIKMLNYEVL QRFYSILSNL PTRKPYYSML CCCNDLLKRI TINKGENLQI 240 241 LQYRWLLIIL NIPTIRTCLI RDRKSKNVFE TQQIRAVSYE LAKRCIGYLS NLSTKTSQQL 300 301 IQSLRRTPTD NFSYQVEILN LYINFQFSRL LSNELSNRTA KNNVKPEDEM RSRLRRHHTT 360 361 GHEFLSTRPI SAQSNDKQGS GFTHPVNNKM KFKFFQYEED WHIHSAAKLT FIYYVANTRR 420 421 NGRGALSIQS FYNITLDFID YKQDFDHW |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
Region A: Residues: [449-559] |
1 11 21 31 41 51 | | | | | | 1 RGVAQKTKMN QLIEEWGNST TKKCFSFCKY PFILSLGIKI SIMEYEIRRI MEHEAEQAFL 60 61 ISLDKGKSVD VYFKIKVRRD VISHDSLRCI KEHQGDLLKS LRIEFVNEPG I |
Detection Method: | |
Confidence: | 710.0103 |
Match: | 1c4zA_ |
Description: | Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap) |
Matching Structure (courtesy of the PDB): |
Region A: Residues: [560-662] |
1 11 21 31 41 51 | | | | | | 1 DAGGLRKEWF FLLTKSLFNP MNGLFIYIKE SSRSWFAIDP PNFDKSKGKN SQLELYYLFG 60 61 VVMGLAIFNS TILDLQFPKA LYKKLCSEPL SFEDYSELFP ETS |
Region B: Residues: [731-774] |
1 11 21 31 41 51 | | | | | | 1 VEFYLEKSIE PQYNKFVSGF KRVFAECNSI KLFNSEELER LVCG |
Detection Method: | |
Confidence: | 710.0103 |
Match: | 1c4zA_ |
Description: | Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap) |
Matching Structure (courtesy of the PDB): |
Region A: Residues: [663-730] |
1 11 21 31 41 51 | | | | | | 1 RNLIKMLNYT EDNFEDVFSL TFETTYRNNN WILNDSKSSK EYVTVELCEN GRNVPITQSN 60 61 KHEFVMKW |
Region B: Residues: [775-892] |
1 11 21 31 41 51 | | | | | | 1 DEEQTKFDFK SLRSVTKYVG GFSDDSRAVC WFWEIIESWD YPLQKKLLQF VTASDRIPAT 60 61 GISTIPFKIS LLGSHDSDDL PLAHTCFNEI CLWNYSSKKK LELKLLWAIN ESEGYGFR |
Detection Method: | |
Confidence: | 710.0103 |
Match: | 1c4zA_ |
Description: | Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap) |
Matching Structure (courtesy of the PDB): |
Region A: Residues: [509-892] |
1 11 21 31 41 51 | | | | | | 1 ISLDKGKSVD VYFKIKVRRD VISHDSLRCI KEHQGDLLKS LRIEFVNEPG IDAGGLRKEW 60 61 FFLLTKSLFN PMNGLFIYIK ESSRSWFAID PPNFDKSKGK NSQLELYYLF GVVMGLAIFN 120 121 STILDLQFPK ALYKKLCSEP LSFEDYSELF PETSRNLIKM LNYTEDNFED VFSLTFETTY 180 181 RNNNWILNDS KSSKEYVTVE LCENGRNVPI TQSNKHEFVM KWVEFYLEKS IEPQYNKFVS 240 241 GFKRVFAECN SIKLFNSEEL ERLVCGDEEQ TKFDFKSLRS VTKYVGGFSD DSRAVCWFWE 300 301 IIESWDYPLQ KKLLQFVTAS DRIPATGIST IPFKISLLGS HDSDDLPLAH TCFNEICLWN 360 361 YSSKKKLELK LLWAINESEG YGFR |
Detection Method: | |
Confidence: | 122.0 |
Match: | 1c4zA |
Description: | Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap) |
Matching Structure (courtesy of the PDB): |
Term | Confidence | Notes |
ubiquitin-protein ligase activity | 7.14616396317218 | bayes_pls_golite062009 |
small conjugating protein ligase activity | 6.99796579811325 | bayes_pls_golite062009 |
acid-amino acid ligase activity | 6.03005793772151 | bayes_pls_golite062009 |
ligase activity, forming carbon-nitrogen bonds | 4.50502148129705 | bayes_pls_golite062009 |
sodium channel inhibitor activity | 3.64966529121446 | bayes_pls_golite062009 |
proline-rich region binding | 3.26053533977534 | bayes_pls_golite062009 |
phosphothreonine binding | 2.3451206920409 | bayes_pls_golite062009 |
phosphoserine binding | 2.3451206920409 | bayes_pls_golite062009 |
binding | 2.32045312021486 | bayes_pls_golite062009 |
ion channel inhibitor activity | 2.14402963004533 | bayes_pls_golite062009 |
channel inhibitor activity | 2.14402963004533 | bayes_pls_golite062009 |
RNA polymerase binding | 1.8762146737407 | bayes_pls_golite062009 |
ligase activity | 1.85936914071714 | bayes_pls_golite062009 |
protein binding | 1.29390544644063 | bayes_pls_golite062009 |
sodium channel regulator activity | 1.19047973745862 | bayes_pls_golite062009 |
catalytic activity | 1.15152367676155 | bayes_pls_golite062009 |
transcription factor binding | 0.585725073778084 | bayes_pls_golite062009 |
nucleic acid binding | 0.509776214744915 | bayes_pls_golite062009 |
transcription regulator activity | 0.376852535152545 | bayes_pls_golite062009 |
ubiquitin-ubiquitin ligase activity | 0.373649200425601 | bayes_pls_golite062009 |
DNA binding | 0.187697131456126 | bayes_pls_golite062009 |
channel regulator activity | 0.072778668515899 | bayes_pls_golite062009 |
0.051942165438844 | bayes_pls_golite062009 |