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Protein Overview: HUL4_YEAST

General Information:
Name(s) found: HUL4_YEAST [Swiss-Prot]
Description(s) found:
  • Probable E3 ubiquitin-protein ligase HUL4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HUL4 PE=1 SV=2 [Swiss-Prot]
    • Organism: Saccharomyces cerevisiae S288c
    Length: 892 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVSLFDKLNA KKDGRDGSVS KELLSHSVAH TKNRLPKSGR RTSERSLAAS VKDGSCSNSK  60
   61 SNKRNSSASV SGEEDKSCLI SLNCLCCGVP LRFPASITKF RCSACQVTVI VKEPEINSNL 120
  121 ESSTHISCTL EGLQMVVRRC HDDLQRLKKT GILDKERKGL IFQPVITYLL DRFHDVSILN 180
  181 RSFLVHDGGK NIKMLNYEVL QRFYSILSNL PTRKPYYSML CCCNDLLKRI TINKGENLQI 240
  241 LQYRWLLIIL NIPTIRTCLI RDRKSKNVFE TQQIRAVSYE LAKRCIGYLS NLSTKTSQQL 300
  301 IQSLRRTPTD NFSYQVEILN LYINFQFSRL LSNELSNRTA KNNVKPEDEM RSRLRRHHTT 360
  361 GHEFLSTRPI SAQSNDKQGS GFTHPVNNKM KFKFFQYEED WHIHSAAKLT FIYYVANTRR 420
  421 NGRGALSIQS FYNITLDFID YKQDFDHWRG VAQKTKMNQL IEEWGNSTTK KCFSFCKYPF 480
  481 ILSLGIKISI MEYEIRRIME HEAEQAFLIS LDKGKSVDVY FKIKVRRDVI SHDSLRCIKE 540
  541 HQGDLLKSLR IEFVNEPGID AGGLRKEWFF LLTKSLFNPM NGLFIYIKES SRSWFAIDPP 600
  601 NFDKSKGKNS QLELYYLFGV VMGLAIFNST ILDLQFPKAL YKKLCSEPLS FEDYSELFPE 660
  661 TSRNLIKMLN YTEDNFEDVF SLTFETTYRN NNWILNDSKS SKEYVTVELC ENGRNVPITQ 720
  721 SNKHEFVMKW VEFYLEKSIE PQYNKFVSGF KRVFAECNSI KLFNSEELER LVCGDEEQTK 780
  781 FDFKSLRSVT KYVGGFSDDS RAVCWFWEII ESWDYPLQKK LLQFVTASDR IPATGISTIP 840
  841 FKISLLGSHD SDDLPLAHTC FNEICLWNYS SKKKLELKLL WAINESEGYG FR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..448] deduced N/A No confident structure predictions are available.
    2 View Details [449..559] PSI-BLAST 710.0103 Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap)
    3 View Details [560..662]
    [731..774]    		 PSI-BLAST 710.0103 Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap)
    4 View Details [663..730]
    [775..892]    		 PSI-BLAST 710.0103 Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap)
    5 View Details [509..892] PSI-BLAST 122.0 Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  7.14616396317218 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  6.99796579811325 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  6.03005793772151 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  4.50502148129705 bayes_pls_golite062009
  • sodium channel inhibitor activity
    		•  3.64966529121446 bayes_pls_golite062009
  • proline-rich region binding
    		•  3.26053533977534 bayes_pls_golite062009
  • phosphothreonine binding
    		•  2.3451206920409 bayes_pls_golite062009
  • phosphoserine binding
    		•  2.3451206920409 bayes_pls_golite062009
  • binding
    		•  2.32045312021486 bayes_pls_golite062009
  • ion channel inhibitor activity
    		•  2.14402963004533 bayes_pls_golite062009
  • channel inhibitor activity
    		•  2.14402963004533 bayes_pls_golite062009
  • RNA polymerase binding
    		•  1.8762146737407 bayes_pls_golite062009
  • ligase activity
    		•  1.85936914071714 bayes_pls_golite062009
  • protein binding
    		•  1.29390544644063 bayes_pls_golite062009
  • sodium channel regulator activity
    		•  1.19047973745862 bayes_pls_golite062009
  • catalytic activity
    		•  1.15152367676155 bayes_pls_golite062009
  • transcription factor binding
    		•  0.585725073778084 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.509776214744915 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.376852535152545 bayes_pls_golite062009
  • ubiquitin-ubiquitin ligase activity
    		•  0.373649200425601 bayes_pls_golite062009
  • DNA binding
    		•  0.187697131456126 bayes_pls_golite062009
  • channel regulator activity
    		•  0.072778668515899 bayes_pls_golite062009
    		• 0.051942165438844 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.72

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle