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View Structure Prediction Details

Protein: FAR1
Organism: Saccharomyces cerevisiae
Length: 830 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FAR1.

Description E-value Query
Range
Subject
Range
gi|171498 - gi|171498|gb|AAA34600.1| factor arrest protein [Saccharomyces cerevisiae]
0.0 [51..830] [1..780]

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Predicted Domain #1
Region A:
Residues: [1-174]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKTPTRVSFE KKIHTPPSGD RDAERSPPKK FLRGLSGKVF RKTPEFKKQQ MPTFGYIEES  60
   61 QFTPNLGLMM SKRGNIPKPL NLSKPISPPP SLKKTAGSVA SGFSKTGQLS ALQSPVNITS 120
  121 SNKYNIKATN LTTSLLRESI SDSTTMCDTL SDINLTVMDE DYRIDGDSYY EEDS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.432 c.2.1 NAD(P)-binding Rossmann-fold domains

Predicted Domain #2
Region A:
Residues: [175-521]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTFMISLERN IKKCNSQFSP KRYIGEKCLI CEESISSTFT GEKVVESTCS HTSHYNCYLM  60
   61 LFETLYFQGK FPECKICGEV SKPKDKDIVP EMVSKLLTGA GAHDDGPSSN MQQQWIDLKT 120
  121 ARSFTGEFPQ FTPQEQLIRT ADISCDGFRT PRLSNSNQFE AVSYLDSPFL NSPFVNKMAT 180
  181 TDPFDLSDDE KLDCDDEIDE SAAEVWFSKT GGEHVMVSVK FQEMRTSDDL GVLQDVNHVD 240
  241 HEELEEREKE WKKKIDQYIE TNVDKDSEFG SLILFDKLMY SDDGEQWVDN NLVILFSKFL 300
  301 VLFDFEEMKI LGKIPRDQFY QVIKFNEDVL LCSLKSTNIP EIYLRFN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 2.70912934275371 bayes_pls_golite062009
transcription regulator activity 2.28868969987463 bayes_pls_golite062009
nucleic acid binding 1.91032952208441 bayes_pls_golite062009
DNA binding 1.68057595006321 bayes_pls_golite062009
protein binding 1.48593945455888 bayes_pls_golite062009
small conjugating protein ligase activity 1.29842157714791 bayes_pls_golite062009
ligase activity 1.14926486052218 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.11631628759929 bayes_pls_golite062009
transcription factor activity 0.94885431027576 bayes_pls_golite062009
transcription factor binding 0.910854221571241 bayes_pls_golite062009
acid-amino acid ligase activity 0.405909265264862 bayes_pls_golite062009
transcription repressor activity 0.185296082082721 bayes_pls_golite062009
catalytic activity 0.168711389690753 bayes_pls_golite062009
transcription cofactor activity 0.0236792532316743 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [522-830]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENCEKWLLPK WKYCLENSSL ETLPLSEIVS TVKELSHVNI IGALGAPPDV ISAQSHDSRL  60
   61 PWKRLHSDTP LKLIVCLNLS HADGELYRKR VLKSVHQILD GLNTDDLLGI VVVGRDGSGV 120
  121 VGPFGTFIGM INKNWDGWTT FLDNLEVVNP NVFRDEKQQY KVTLQTCERL ASTSAYVDTD 180
  181 DHIATGYAKQ ILVLNGSDVV DIEHDQKLKK AFDQLSYHWR YEISQRRMTP LNASIKQFLE 240
  241 ELHTKRYLDV TLRLPQATFE QVYLGDMAAG EQKTRLIMDE HPHSSLIEIE YFDLVKQQRI 300
  301 HQTLEVPNL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [458-566]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GEQWVDNNLV ILFSKFLVLF DFEEMKILGK IPRDQFYQVI KFNEDVLLCS LKSTNIPEIY  60
   61 LRFNENCEKW LLPKWKYCLE NSSLETLPLS EIVSTVKELS HVNIIGALG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [567-830]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APPDVISAQS HDSRLPWKRL HSDTPLKLIV CLNLSHADGE LYRKRVLKSV HQILDGLNTD  60
   61 DLLGIVVVGR DGSGVVGPFG TFIGMINKNW DGWTTFLDNL EVVNPNVFRD EKQQYKVTLQ 120
  121 TCERLASTSA YVDTDDHIAT GYAKQILVLN GSDVVDIEHD QKLKKAFDQL SYHWRYEISQ 180
  181 RRMTPLNASI KQFLEELHTK RYLDVTLRLP QATFEQVYLG DMAAGEQKTR LIMDEHPHSS 240
  241 LIEIEYFDLV KQQRIHQTLE VPNL

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.0
Match: 1t6bY
Description: Crystal structure of B. anthracis Protective Antigen complexed with human Anthrax toxin receptor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.68315152218267 bayes_pls_golite062009
nucleic acid binding 1.69563050637199 bayes_pls_golite062009
DNA binding 1.5974492205508 bayes_pls_golite062009
protein binding 1.42792331963866 bayes_pls_golite062009
protein complex binding 1.2199981922324 bayes_pls_golite062009
receptor binding 1.00252885030613 bayes_pls_golite062009
receptor activity 0.898641472317111 bayes_pls_golite062009
signal transducer activity 0.670518084602683 bayes_pls_golite062009
molecular transducer activity 0.670518084602683 bayes_pls_golite062009
structural molecule activity 0.344350079952659 bayes_pls_golite062009
peptide binding 0.0829901132484674 bayes_pls_golite062009
catalytic activity 0.0380261580236634 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle