YRC Public Data Repository - Protein Structure Prediction

Protein:	BNR1
Organism:	Saccharomyces cerevisiae
Length:	1375 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BNR1.

Description	E-value	Query Range	Subject Range
BNR1 - Formin, nucleates the formation of linear actin filaments, involved in cell processes such as buddin... BNR1_YEAST - BNI1-related protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=BNR1 PE=1 SV=1	0.0	[1..1375]	[1..1375]
SEPA_EMENI - Cytokinesis protein sepA OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194... SEPA_EMENI - Cytokinesis protein sepA OS=Emericella nidulans GN=sepA PE=3 SV=2	0.0	[96..598]	[276..806]
gi\|3327146 - gi\|3327146\|dbj\|BAA31641.1\| KIAA0666 protein [Homo sapiens]	0.0	[86..595]	[46..528]
gi\|4101720, gi\|9... - gi\|9789953\|ref\|NP_062653.1\| lymphocyte specific formin related protein [Mus musculus], pir\|\|T13963 f...	0.0	[589..1328]	[334..1018]
FH1_ARATH - Formin-like protein 1 OS=Arabidopsis thaliana GN=FH1 PE=1 SV=1	0.0	[600..1277]	[319..997]
gi\|6691125 - gi\|6691125\|gb\|AAF24497.1\|AF213696_1 FH protein NFH2 [Nicotiana tabacum]	2.0E-92	[692..1277]	[230..795]

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Predicted Domain #1

Region A:
Residues: [1-162]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSSPNKKTY RYPRRSLSLH ARDRVSEARK LEELNLNDGL VAAGLQLVGV ALEKQGTGSH  60
   61 IYMKQKNFSA NDVSSSPMVS EEVNGSEMDF NPKCMPQDAS LVERMFDELL KDGTFFWGAA 120
  121 YKNLQNISLR RKWLLICKIR SSNHWGKKKV TSSTTYSTHL AT

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [163-291]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NELAENAHFL DGLVRNLSTG GMKLSKALYK LEKFLRKQSF LQLFLKDEIY LTTLIEKTLP  60
   61 LISKELQFVY LRCFKILMNN PLARIRALHS EPLIRWFTEL LTDQNSNLKC QLLSMELLLL 120
  121 LTYVEGSTG

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	8.79
Match:	1jpwA
Description:	beta-Catenin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
actin binding	3.34487439883854	bayes_pls_golite062009
binding	2.6374633159018	bayes_pls_golite062009
cytoskeletal protein binding	2.61566088685247	bayes_pls_golite062009
protein transporter activity	2.56209426863971	bayes_pls_golite062009
protein binding	1.73688475473996	bayes_pls_golite062009
protein transmembrane transporter activity	0.856755253686635	bayes_pls_golite062009
transporter activity	0.825258162383893	bayes_pls_golite062009
enzyme regulator activity	0.698613639309592	bayes_pls_golite062009
substrate-specific transporter activity	0.500493982824973	bayes_pls_golite062009
nucleic acid binding	0.345785895390889	bayes_pls_golite062009
signal sequence binding	0.27824906981293	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.248376041999546	bayes_pls_golite062009
pyrophosphatase activity	0.20813279031582	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.197447861665299	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.196910953077117	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	0.0332743336452223	bayes_pls_golite062009
GTPase regulator activity	0.0268373969988844	bayes_pls_golite062009
guanyl ribonucleotide binding	0.00234756529236324	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [292-393]

      1          11         21         31         41         51         
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    1 CELIWDQLSI LFTDWLEWFD KILADDIAIH SSLYLNWNQL KIDYSTTFLL LINSILQGFN  60
   61 NKTALEILNF LKKNNIHNTI TFLELAYKDD PNSVVIMEQI KQ

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	8.79
Match:	1jpwA
Description:	beta-Catenin
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [394-522]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FKSKESAIFD SMIKTTNDTN SLHPTKDIAR IESEPLCLEN CLLLKAKDSP VEAPINEIIQ  60
   61 SLWKILDSQK PYSESIKLLK LINSLLFYLI DSFQVSTNPS FDETLESAEN VDYVFQDSVN 120
  121 KLLDSLQSD

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	8.79
Match:	1jpwA
Description:	beta-Catenin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
actin binding	4.76659069034376	bayes_pls_golite062009
cytoskeletal protein binding	3.48744511411671	bayes_pls_golite062009
actin filament binding	2.99963220150463	bayes_pls_golite062009
binding	2.86147407357315	bayes_pls_golite062009
protein binding	2.12168271674167	bayes_pls_golite062009
GTPase regulator activity	1.66986263418539	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	1.64990514605397	bayes_pls_golite062009
small GTPase regulator activity	1.2550809703725	bayes_pls_golite062009
enzyme regulator activity	1.25381967078645	bayes_pls_golite062009
profilin binding	0.91195854193678	bayes_pls_golite062009
small GTPase binding	0.8507658747425	bayes_pls_golite062009
GTPase binding	0.82889812790119	bayes_pls_golite062009
guanyl-nucleotide exchange factor activity	0.745321902095093	bayes_pls_golite062009
structural constituent of cytoskeleton	0.35466574267734	bayes_pls_golite062009
structural constituent of muscle	0.276130226777911	bayes_pls_golite062009
pyrophosphatase activity	0.205756341419244	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.195095639672769	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.19455798195809	bayes_pls_golite062009
phosphatidylinositol-4,5-bisphosphate binding	0.0524318525517602	bayes_pls_golite062009

Predicted Domain #5

Region A:
Residues: [523-603]

      1          11         21         31         41         51         
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    1 EIARRAVTEI DDLNAKISHL NEKLNLVENH DKDHLIAKLD ESESLISLKT KEIENLKLQL  60
   61 KATKKRLDQI TTHQRLYDQP P

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	8.79
Match:	1jpwA
Description:	beta-Catenin
Matching Structure (courtesy of the PDB):

Predicted Domain #6

Region A:
Residues: [604-665]

      1          11         21         31         41         51         
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    1 SLASSNLSIA GSIIKNNSHG NIIFQNLAKK QQQQQKISLP KRSTSLLKSK RVTSLSSYLT  60
   61 DA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	6.154902
Match:	1dynA_
Description:	Dynamin
Matching Structure (courtesy of the PDB):

Predicted Domain #7

Region A:
Residues: [666-867]

      1          11         21         31         41         51         
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    1 NNENESQNES EDKSKDSLFQ RSTSTINFNI PSMKNITNMQ NVSLNSILSE LEFSNSLGTQ  60
   61 PNYQSSPVLS SVSSSPKLFP RLSSDSLDNG IQLVPEVVKL PQLPPPPPPP PPPPLPQSLL 120
  121 TEAEAKPDGV SCIAAPAPPP LPDLFKTKTC GAVPPPPPPP PLPESLSMNK GPSNHDLVTP 180
  181 PAPPLPNGLL SSSSVSINPT TT

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	11.94
Match:	1deqA
Description:	Fibrinogen
Matching Structure (courtesy of the PDB):

Predicted Domain #8

Region A:
Residues: [868-951]

      1          11         21         31         41         51         
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    1 DLKPPPTEKR LKQIHWDKVE DIKDTLWEDT FQRQETIKEL QTDGIFSQIE DIFKMKSPTK  60
   61 IANKRNAESS IALSSNNGKS SNEL

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.335	a.118.14	FliG
View	Download	0.298	a.134.1	Fungal elicitin
View	Download	0.449	a.23.4	Mitochondrial import receptor subunit Tom20
View	Download	0.423	a.51.1	Cytochrome c oxidase subunit h
View	Download	0.366	a.179.1	Replisome organizer (g39p helicase loader/inhibitor protein)
View	Download	0.285	a.46.2	Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View	Download	0.241	a.52.1	Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View	Download	0.238	d.68.5	C-terminal domain of ProRS
View	Download	0.235	a.74.1	Cyclin-like
View	Download	0.233	a.46.2	Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View	Download	0.214	a.65.1	Annexin
View	Download	0.214	a.76.1	Iron-dependent represor protein, dimerization domain
View	Download	0.213	a.3.1	Cytochrome c
View	Download	0.203	a.4.1	Homeodomain-like
View	Download	0.201	a.83.1	Guanido kinase N-terminal domain

Predicted Domain #9

Region A:
Residues: [952-999]

      1          11         21         31         41         51         
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    1 KKISFLSRDL AQQFGINLHM FSQLSDMEFV MKVLNCDNDI VQNVNILK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [1069-1122]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLIFKLQKID DAISHLNRSP KFKSLMFIIT EIGNHMNKRI VKGIKLKSLT KLAF

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.79
Match:	1l9zH
Description:	DNA-directed RNA polymerase alpha(2), beta, beta-prime and omega subunits
Matching Structure (courtesy of the PDB):

Predicted Domain #10

Region A:
Residues: [1000-1068]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FFCKEELVNI PKSMLNKYEP YSQGKDGKAV SDLQRADRIF LELCINLRFY WNARSKSLLT  60
   61 LSTYERDYY

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [1123-1200]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VRSSIDQNVS FLHFIEKVIR IKYPDIYGFV DDLKNIEDLG KISLEHVESE CHEFHKKIED  60
   61 LVTQFQVGKL SKEENLDP

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.79
Match:	1l9zH
Description:	DNA-directed RNA polymerase alpha(2), beta, beta-prime and omega subunits
Matching Structure (courtesy of the PDB):

Predicted Domain #11

Region A:
Residues: [1201-1323]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RDQIIKKVKF KINRAKTKSE LLIGQCKLTL IDLNKLMKYY GEDPKDKESK NEFFQPFIEF  60
   61 LAMFKKCAKE NIEKEEMERV YEQRKSLLDM RTSSNKKSNG SDENDGEKVN RDAVDLLISK 120
  121 LRE

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.79
Match:	1l9zH
Description:	DNA-directed RNA polymerase alpha(2), beta, beta-prime and omega subunits
Matching Structure (courtesy of the PDB):

Predicted Domain #12

Region A:
Residues: [1324-1375]

      1          11         21         31         41         51         
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    1 VKKDPEPLRR RKSTKLNEIA INVHEGDVKT RKDEDHVLLE RTHAMLNDIQ NI

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.580	a.5.2	UBA-like
View	Download	0.597	a.5.7	4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View	Download	0.361	a.23.5	Hemolysin expression modulating protein HHA
View	Download	0.240	a.2.10	Epsilon subunit of F1F0-ATP synthase C-terminal domain
View	Download	0.229	a.108.1	Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View	Download	0.222	a.4.1	Homeodomain-like
View	Download	0.215	f.14.1	Voltage-gated potassium channels
View	Download	0.206	a.2.7	tRNA-binding arm

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: