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View Structure Prediction Details

Protein: ATG7
Organism: Saccharomyces cerevisiae
Length: 630 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ATG7.

Description E-value Query
Range
Subject
Range
ATG7 - Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzym...
ATG7_YEAST - Ubiquitin-like modifier-activating enzyme ATG7 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S28...
0.0 [1..630] [1..630]
ATG7 - ATG7 autophagy related 7 homolog (S. cerevisiae)
0.0 [7..626] [13..702]
ATG7_MOUSE - Ubiquitin-like modifier-activating enzyme ATG7 OS=Mus musculus GN=Atg7 PE=1 SV=1
0.0 [7..626] [9..697]
Atg7-PA - The gene Autophagy-specific gene 7 is referred to in FlyBase by the symbol Dmel\Atg7 (CG5489, FBgn00...
gi|220948278 - gi|220948278|gb|ACL86682.1| Atg7-PA [synthetic construct]
0.0 [1..627] [1..677]
SPBC6B1.05c - ubiquitin-like conjugating enzyme
ATG7_SCHPO - Ubiquitin-like modifier-activating enzyme atg7 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843...
0.0 [1..629] [1..648]
gi|9758937 - gi|9758937|dbj|BAB09318.1| ubiquitin activating enzyme E1-like protein [Arabidopsis thaliana]
0.0 [6..615] [10..661]
ATG7_PICPA - Ubiquitin-like modifier-activating enzyme ATG7 OS=Komagataella pastoris GN=ATG7 PE=1 SV=1
0.0 [14..628] [12..648]
atg-7 - Yeast YHX1 like status:Confirmed UniProt:Q21591 protein_id:CAA92753.1
0.0 [9..613] [4..636]

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Predicted Domain #1
Region A:
Residues: [1-293]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSERVLSYA PAFKSFLDTS FFQELSRLKL DVLKLDSTCQ PLTVNLDLHN IPKSADQVPL  60
   61 FLTNRSFEKH NNKRTNEVPL QGSIFNFNVL DEFKNLDKQL FLHQRALECW EDGIKDINKC 120
  121 VSFVIISFAD LKKYRFYYWL GVPCFQRPSS TVLHVRPEPS LKGLFSKCQK WFDVNYSKWV 180
  181 CILDADDEIV NYDKCIIRKT KVLAIRDTST MENVPSALTK NFLSVLQYDV PDLIDFKLLI 240
  241 IRQNEGSFAL NATFASIDPQ SSSSNPDMKV SGWERNVQGK LAPRVVDLSS LLD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [294-630]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLKIADQSVD LNLKLMKWRI LPDLNLDIIK NTKVLLLGAG TLGCYVSRAL IAWGVRKITF  60
   61 VDNGTVSYSN PVRQALYNFE DCGKPKAELA AASLKRIFPL MDATGVKLSI PMIGHKLVNE 120
  121 EAQHKDFDRL RALIKEHDII FLLVDSRESR WLPSLLSNIE NKTVINAALG FDSYLVMRHG 180
  181 NRDEQSSKQL GCYFCHDVVA PTDSLTDRTL DQMCTVTRPG VAMMASSLAV ELMTSLLQTK 240
  241 YSGSETTVLG DIPHQIRGFL HNFSILKLET PAYEHCPACS PKVIEAFTDL GWEFVKKALE 300
  301 HPLYLEEISG LSVIKQEVER LGNDVFEWED DESDEIA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 166.30103
Match: 1jw9B_
Description: Molybdenum cofactor biosynthesis protein MoeB
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [300-630]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QSVDLNLKLM KWRILPDLNL DIIKNTKVLL LGAGTLGCYV SRALIAWGVR KITFVDNGTV  60
   61 SYSNPVRQAL YNFEDCGKPK AELAAASLKR IFPLMDATGV KLSIPMIGHK LVNEEAQHKD 120
  121 FDRLRALIKE HDIIFLLVDS RESRWLPSLL SNIENKTVIN AALGFDSYLV MRHGNRDEQS 180
  181 SKQLGCYFCH DVVAPTDSLT DRTLDQMCTV TRPGVAMMAS SLAVELMTSL LQTKYSGSET 240
  241 TVLGDIPHQI RGFLHNFSIL KLETPAYEHC PACSPKVIEA FTDLGWEFVK KALEHPLYLE 300
  301 EISGLSVIKQ EVERLGNDVF EWEDDESDEI A

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 69.39794
Match: 1jw9B
Description: Molybdenum cofactor biosynthesis protein MoeB
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
small protein activating enzyme activity 3.58068602287881 bayes_pls_golite062009
NEDD8 activating enzyme activity 2.11391077579348 bayes_pls_golite062009
small conjugating protein ligase activity 1.84216910649062 bayes_pls_golite062009
binding 1.66028321721112 bayes_pls_golite062009
transcription regulator activity 1.54883560427918 bayes_pls_golite062009
protein binding 1.40907622346701 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.31244773198273 bayes_pls_golite062009
acid-amino acid ligase activity 1.27535252106053 bayes_pls_golite062009
catalytic activity 1.22201444897049 bayes_pls_golite062009
transferase activity 0.680338489823338 bayes_pls_golite062009
URM1 activating enzyme activity 0.207228630005671 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle