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View Structure Prediction Details

Protein: YAP1801
Organism: Saccharomyces cerevisiae
Length: 637 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YAP1801.

Description E-value Query
Range		 Subject
Range
AP18A_YEAST - Clathrin coat assembly protein AP180A OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YA...
YAP1801 - Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1802p, member...
 0.0 [1..637] [1..637]
gi|15079267, gi|... - gi|74189804|dbj|BAE36872.1| unnamed protein product [Mus musculus], gi|15079267|gb|AAH11470.1| Pical...
 0.0 [2..627] [20..651]
PICAL_RAT - Phosphatidylinositol-binding clathrin assembly protein OS=Rattus norvegicus GN=Picalm PE=1 SV=1
 0.0 [2..627] [20..636]
CAP9_ARATH - Putative clathrin assembly protein At1g14910 OS=Arabidopsis thaliana GN=At1g14910 PE=2 SV=2
 0.0 [3..604] [31..611]
unc-11 - status:Confirmed UniProt:Q9XZI6 protein_id:AAK68212.1
 0.0 [2..512] [35..539]

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Predicted Domain #1
Region A:
Residues: [1-122] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTYFKLVKG ATKIKSAPPK QKYLDPILLG TSNEEDFYEI VKGLDSRIND TAWTIVYKSL  60
   61 LVVHLMIREG SKDVALRYYS RNLEFFDIEN IRGSNGSASG DMRALDRYDN YLKVRCREFG 120
  121 KI

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [167-192] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ALIKNKYTQY DLSNELIIFG FKLLIQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 298.519517
Match: 1hf8A_
Description: Clathrin assembly lymphoid myeloid leukaemia protein, Calm
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
clathrin binding 2.70535896247543 bayes_pls_golite062009
binding 2.34501465852339 bayes_pls_golite062009
protein binding 1.7891964555817 bayes_pls_golite062009
phosphatidylinositol-4,5-bisphosphate binding 1.20269437433936 bayes_pls_golite062009
phosphoinositide binding 0.87586037360588 bayes_pls_golite062009
phospholipid binding 0.84481265656013 bayes_pls_golite062009
lipid binding 0.176990783274449 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [123-166] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKDYVRDGYR TLKLNSGNYG SSRNKQHSIN IALDHVESLE VQIQ

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [193-271] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLLALYNALN EGIITLLESF FELSHHNAER TLDLYKTFVD LTEHVVRYLK SGKTAGLKIP  60
   61 VIKHITTKLV RSLEEHLIE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 298.519517
Match: 1hf8A_
Description: Clathrin assembly lymphoid myeloid leukaemia protein, Calm
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [272-338] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDKTHNTFVP VDSSQGSAGA VVAKSTAQER LEQIREQKRI LEAQLKNEQV AISPALTTVT  60
   61 AAQSYNP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.332 0.921 clathrin binding a.39.1 EF-hand

Predicted Domain #4
Region A:
Residues: [339-637] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FGTDSSMHTN IPMAVANQTQ QIANNPFVSQ TQPQVMNTPT AHTEPANLNV PEYAAVQHTV  60
   61 NFNPVQDAGV SAQQTGYYSI NNHLTPTFTG AGFGGYSVSQ DTTAASNQQV SHSQTGSNNP 120
  121 FALHNAATIA TGNPAHENVL NNPFSRPNFD EQNTNMPLQQ QIISNPFQNQ TYNQQQFQQQ 180
  181 KMPLSSINSV MTTPTSMQGS MNIPQRFDKM EFQAHYTQNH LQQQQQQQQQ QQQQQQQQPQ 240
  241 QGYYVPATAG ANPVTNITGT VQPQNFPFYP QQQPQPEQSQ TQQPVLGNQY ANNLNLIDM

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle