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View Structure Prediction Details

Protein: DYS1
Organism: Saccharomyces cerevisiae
Length: 387 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DYS1.

Description E-value Query
Range
Subject
Range
DHPS - deoxyhypusine synthase
gi|190689417, gi... - gi|190690779|gb|ACE87164.1| deoxyhypusine synthase protein [synthetic construct], gi|190689417|gb|AC...
0.0 [6..379] [7..358]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [6..379] [7..358]
DYS1 - Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesi...
gi|207344688 - gi|207344688|gb|EDZ71748.1| YHR068Wp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190405850 - gi|190405850|gb|EDV09117.1| deoxyhypusine synthase [Saccharomyces cerevisiae RM11-1a]
DHYS_YEAST - Deoxyhypusine synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DYS1 PE=1 SV=1
0.0 [1..387] [1..387]
DHYS_SENVE - Deoxyhypusine synthase OS=Senecio vernalis GN=DHS1 PE=2 SV=1
0.0 [1..381] [1..364]
DHYS_ARATH - Deoxyhypusine synthase OS=Arabidopsis thaliana GN=DHS PE=2 SV=1
0.0 [5..380] [3..360]
DHYS_TOBAC - Deoxyhypusine synthase OS=Nicotiana tabacum GN=DHS1 PE=2 SV=1
0.0 [9..380] [8..369]
DHYS_SOLLC - Deoxyhypusine synthase OS=Solanum lycopersicum GN=DHS PE=2 SV=1
0.0 [8..379] [9..370]
DHYS_DIACA - Deoxyhypusine synthase OS=Dianthus caryophyllus GN=DHS PE=2 SV=1
0.0 [1..384] [1..370]

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Predicted Domain #1
Region A:
Residues: [1-387]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDINEKLPE LLQDAVLKAS VPIPDDFVKV QGIDYSKPEA TNMRATDLIE AMKTMGFQAS  60
   61 SVGTACEIID SMRSWRGKHI DELDDHEKKG CFDEEGYQKT TIFMGYTSNL ISSGVRETLR 120
  121 YLVQHKMVDA VVTSAGGVEE DLIKCLAPTY LGEFALKGKS LRDQGMNRIG NLLVPNDNYC 180
  181 KFEEWIVPIL DKMLEEQDEY VKKHGADCLE ANQDVDSPIW TPSKMIDRFG KEINDESSVL 240
  241 YWAHKNKIPI FCPSLTDGSI GDMLFFHTFK ASPKQLRVDI VGDIRKINSM SMAAYRAGMI 300
  301 ILGGGLIKHH IANACLMRNG ADYAVYINTG QEYDGSDAGA RPDEAVSWGK IKAEAKSVKL 360
  361 FADVTTVLPL IVAATFASGK PIKKVKN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1340.0
Match: 1dhs__
Description: Deoxyhypusine synthase, DHS
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
deoxyhypusine synthase activity 4.8590235726137 bayes_pls_golite062009
transcription regulator activity 2.51117258094456 bayes_pls_golite062009
protein deacetylase activity 2.11398191156761 bayes_pls_golite062009
DNA binding 2.09930834951157 bayes_pls_golite062009
histone deacetylase activity 2.08718650273166 bayes_pls_golite062009
binding 2.06552694538163 bayes_pls_golite062009
nucleic acid binding 2.00972611627502 bayes_pls_golite062009
NAD-dependent protein deacetylase activity 1.93141177609772 bayes_pls_golite062009
NAD-dependent histone deacetylase activity 1.93141177609772 bayes_pls_golite062009
protein binding 1.52593340148652 bayes_pls_golite062009
deacetylase activity 1.15111805612466 bayes_pls_golite062009
transcription factor binding 1.07103864164531 bayes_pls_golite062009
transcription factor activity 1.0180828203704 bayes_pls_golite062009
catalytic activity 0.739210399081789 bayes_pls_golite062009
transcription repressor activity 0.516307124442946 bayes_pls_golite062009
transferase activity 0.483523935618287 bayes_pls_golite062009
transcription cofactor activity 0.42635585193838 bayes_pls_golite062009
transcription corepressor activity 0.23414654967509 bayes_pls_golite062009
hydrolase activity 0.169696911903799 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle