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View Structure Prediction Details

Protein: YHR020W
Organism: Saccharomyces cerevisiae
Length: 688 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YHR020W.

Description E-value Query
Range		 Subject
Range
YHI0_YEAST - Putative proline--tRNA ligase YHR020W OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YH...
YHR020W - Protein of unknown function that may interact with ribosomes, based on co-purification experiments; ...
 0.0 [1..688] [1..688]
SPBC19C7.06 - proline-tRNA ligase
PRS1_SCHPO - Putative proline--tRNA ligase C19C7.06 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=prs...
 0.0 [7..688] [33..716]
SYP_ENCCU - Proline--tRNA ligase OS=Encephalitozoon cuniculi (strain GB-M1) GN=ECU02_1360 PE=1 SV=1
SYP_ENCCU - Prolyl-tRNA synthetase OS=Encephalitozoon cuniculi GN=ECU02_1360 PE=1 SV=1
 0.0 [180..688] [20..520]
SYP_CLOST - Prolyl-tRNA synthetase OS=Clostridium sticklandii GN=proS PE=1 SV=1
SYP_CLOSD - Proline--tRNA ligase OS=Clostridium sticklandii (strain ATCC 12662 / DSM 519 / JCM 1433 / NCIB 10654...
 0.0 [178..688] [2..481]
SYP_PYRHO - Prolyl-tRNA synthetase OS=Pyrococcus horikoshii GN=proS PE=3 SV=2
SYP_PYRHO - Proline--tRNA ligase OS=Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 1001...
 0.0 [179..688] [2..480]
SYPC_ARATH - Proline--tRNA ligase, cytoplasmic OS=Arabidopsis thaliana GN=At3g62120 PE=2 SV=1
 0.0 [145..688] [5..530]
SYP_PYRAB - Prolyl-tRNA synthetase OS=Pyrococcus abyssi GN=proS PE=3 SV=1
SYP_PYRAB - Proline--tRNA ligase OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=proS PE=3 SV=1
 0.0 [179..688] [2..480]
SYP_PYRFU - Prolyl-tRNA synthetase OS=Pyrococcus furiosus GN=proS PE=3 SV=1
SYP_PYRFU - Proline--tRNA ligase OS=Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) GN=proS ...
 0.0 [189..688] [5..479]
SYP_SULTO - Proline--tRNA ligase OS=Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) GN=proS...
SYP_SULTO - Prolyl-tRNA synthetase OS=Sulfolobus tokodaii GN=proS PE=3 SV=1
 0.0 [192..688] [9..483]
SYT_DEIRA - Threonine--tRNA ligase OS=Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4...
SYT_DEIRA - Threonine--tRNA ligase OS=Deinococcus radiodurans GN=thrS PE=3 SV=1
 0.0 [2..580] [49..648]

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Predicted Domain #1
Region A:
Residues: [1-586] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPVSEAFAKL CVNEKPPAES AVAVKSLVFK PKTPKSATPV PIVVVALQST TTPSALIANA  60
   61 TSSKDPRLAR DDLVKQAFQS ESARAFILGD LANATSNFHL LIDHELGTVD GDTILQLNDS 120
  121 TYMKKSDMMK FLNNFEDSQK VVDFSQEVSK ETATEGKKQQ KKQQPSKAGT AAAAAAAALE 180
  181 DAKLIGITVD KALDFPGWYQ QILTKGEMLD YYDVSGCYIL RPPSYAIWEN IQKWFDDKIK 240
  241 AIGVQNAYFP MFVSSRVLEK EKDHVEGFAP EVAWVTRAGS SELEEPIAIR PTSETVMYPY 300
  301 YAKWVQSYRD LPLKLNQWNS VVRWEFKHPQ PFLRTREFLW QEGHTAHLTA KDAEEEVLQI 360
  361 LDFYAGVYEE LLAVPVVKGR KTEKEKFAGG DFTTTCEGYI PQTGRGIQGA TSHHLGQNFS 420
  421 KMFNLSVENP LGSDHPKIFA YQNSWGLSTR VIGVMVMIHS DNKGLVIPPR VSQFQSVVIP 480
  481 VGITKKTSEE QRKHIHETAR SVESRLKKVG IRAFGDYNDN YTPGWKFSQY ELKGIPIRIE 540
  541 LGPKDIEKNQ VVVVRRNDSK KYVVSFDELE ARIPEILEEM QGDLFK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 143.9897
Match: 1qf6A_
Description: Threonyl-tRNA synthetase (ThrRS), C-terminal domain; Threonyl-tRNA synthetase (ThrRS), N-terminal 'additional' domain; Threonyl-tRNA synthetase (ThrRS), second 'additional' domain; Threonyl-tRNA synthetase (ThrRS)
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [587-688] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KAKELFDTHR VIVNEWSGFV PALNKKNVIL APWCGVMECE EDIKESSAKK DDGEEFEEDD  60
   61 KAPSMGAKSL CIPFDQPVLN EGQKCIKCER IAVNYCMFGR SY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1170.0
Match: 1h4qA_
Description: Prolyl-tRNA synthetase (ProRS) domain; C-terminal domain of ProRS; Prolyl-tRNA synthetase (ProRS)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
proline-tRNA ligase activity 7.67335999089351 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 6.0520403280225 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 6.0520403280225 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 6.04138870254626 bayes_pls_golite062009
ligase activity 4.85905957427768 bayes_pls_golite062009
phenylalanine-tRNA ligase activity 3.22631630581238 bayes_pls_golite062009
glycine-tRNA ligase activity 2.29229136935761 bayes_pls_golite062009
threonine-tRNA ligase activity 2.18642354927 bayes_pls_golite062009
serine-tRNA ligase activity 2.07594942154162 bayes_pls_golite062009
alanine-tRNA ligase activity 1.82594054955281 bayes_pls_golite062009
lysine-tRNA ligase activity 1.72324031407565 bayes_pls_golite062009
histidine-tRNA ligase activity 1.72215103383322 bayes_pls_golite062009
binding 1.30923742450698 bayes_pls_golite062009
asparagine-tRNA ligase activity 0.921492123574877 bayes_pls_golite062009
catalytic activity 0.902495165806215 bayes_pls_golite062009
RNA binding 0.576453255038334 bayes_pls_golite062009
protein binding 0.358563180490135 bayes_pls_golite062009
transcription regulator activity 0.236290074198593 bayes_pls_golite062009
nucleic acid binding 0.202044919116061 bayes_pls_golite062009
aspartate-tRNA ligase activity 0.00572514744734753 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [605-688] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FVPALNKKNV ILAPWCGVME CEEDIKESSA KKDDGEEFEE DDKAPSMGAK SLCIPFDQPV  60
   61 LNEGQKCIKC ERIAVNYCMF GRSY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 116.0
Match: 1h4qA
Description: Prolyl-tRNA synthetase (ProRS) domain; C-terminal domain of ProRS; Prolyl-tRNA synthetase (ProRS)
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle