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View Structure Prediction Details

Protein: UBR1
Organism: Saccharomyces cerevisiae
Length: 1950 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for UBR1.

Description E-value Query
Range
Subject
Range
UBR1 - E3 ubiquitin ligase (N-recognin), forms heterodimer with Rad6p to ubiquitinate substrates in the N-e...
UBR1_YEAST - E3 ubiquitin-protein ligase UBR1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UBR1 PE...
0.0 [1..1950] [1..1950]
UBR1_KLULA - E3 ubiquitin-protein ligase UBR1 OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / ...
UBR1_KLULA - E3 ubiquitin-protein ligase UBR1 OS=Kluyveromyces lactis GN=UBR1 PE=3 SV=2
0.0 [11..1948] [11..1916]
ubr1 - N-end-recognizing protein Ubr1
UBR1_SCHPO - E3 ubiquitin-protein ligase ubr1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ubr1 PE=3...
0.0 [30..1387] [10..1393]
CE08535 - WBGene00016326 status:Partially_confirmed SW:P91133 protein_id:AAB42328.1
0.0 [120..1334] [13..1265]
UBR1_MOUSE - E3 ubiquitin-protein ligase UBR1 OS=Mus musculus GN=Ubr1 PE=1 SV=1
0.0 [488..1361] [322..1243]
UBR11_SCHPO - E3 ubiquitin-protein ligase ubr11 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ubr11 PE...
ubr11 - N-end-recognizing protein
0.0 [479..1423] [574..1554]
gi|2224639 - gi|2224639|dbj|BAA20806.1| KIAA0349 [Homo sapiens]
0.0 [639..1820] [5..1269]

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Predicted Domain #1
Region A:
Residues: [1-75]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVADDDLGS LQGHIRRTLR SIHNLPYFRY TRGPTERADM SRALKEFIYR YLYFVISNSG  60
   61 ENLPTLFNAH PKQKL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.475 a.16.1 S15/NS1 RNA-binding domain
View Download 0.527 a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.509 f.17.1 F1F0 ATP synthase subunit C
View Download 0.471 d.58.49 YajQ-like
View Download 0.862 a.112.1 Description not found.
View Download 0.862 a.112.1 Description not found.
View Download 0.527 a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.509 f.17.1 F1F0 ATP synthase subunit C
View Download 0.505 a.112.1 Description not found.
View Download 0.494 a.112.1 Description not found.
View Download 0.454 a.7.6 Ribosomal protein S20
View Download 0.442 a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.427 a.24.17 Group V grass pollen allergen
View Download 0.420 a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.396 a.64.1 Saposin
View Download 0.391 a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.385 f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.370 d.52.7 Ribosome-binding factor A, RbfA
View Download 0.357 f.15.1 Small-conductance potassium channel
View Download 0.338 a.39.4 Hypothetical protein MTH865
View Download 0.337 a.2.3 Chaperone J-domain
View Download 0.312 a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.303 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.286 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.277 a.22.1 Histone-fold
View Download 0.275 a.7.7 BAG domain
View Download 0.275 a.2.7 tRNA-binding arm
View Download 0.271 a.2.10 Epsilon subunit of F1F0-ATP synthase C-terminal domain
View Download 0.266 a.2.4 Theta subunit of DNA polymerase III
View Download 0.262 d.52.5 Probable GTPase Der, C-terminal domain
View Download 0.261 a.3.1 Cytochrome c
View Download 0.259 a.58.1 Chemotaxis receptor methyltransferase CheR, N-terminal domain
View Download 0.256 a.64.1 Saposin
View Download 0.255 a.61.1 Retroviral matrix proteins
View Download 0.250 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.247 f.13.1 Family A G protein-coupled receptor-like
View Download 0.246 a.4.5 "Winged helix" DNA-binding domain
View Download 0.243 d.80.1 Tautomerase/MIF
View Download 0.240 a.74.1 Cyclin-like
View Download 0.234 d.150.1 4'-phosphopantetheinyl transferase
View Download 0.232 a.4.1 Homeodomain-like
View Download 0.221 a.151.1 Glutamyl tRNA-reductase dimerization domain
View Download 0.204 a.2.2 Ribosomal protein L29 (L29p)
View Download 0.200 a.26.1 4-helical cytokines
View Download 0.200 a.57.1 Protein HNS-dependent expression A; HdeA

Predicted Domain #2
Region A:
Residues: [76-205]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNPELTVFPD SLEDAVDIDK ITSQQTIPFY KIDESRIGDV HKHTGRNCGR KFKIGEPLYR  60
   61 CHECGCDDTC VLCIHCFNPK DHVNHHVCTD ICTEFTSGIC DCGDEEAWNS PLHCKAEEQE 120
  121 NDISEDPATN 

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 35.853872
Match: PF02207
Description: Putative zinc finger in N-recognin

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.261 N/A N/A b.60.1 Lipocalins
View Download 0.255 N/A N/A b.60.1 Lipocalins

Predicted Domain #3
Region A:
Residues: [206-684]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADIKEEDVWN DSVNIALVEL VLAEVFDYFI DVFNQNIEPL PTIQKDITIK LREMTQQGKM  60
   61 YERAQFLNDL KYENDYMFDG TTTAKTSPSN SPEASPSLAK IDPENYTVII YNDEYHNYSQ 120
  121 ATTALRQGVP DNVHIDLLTS RIDGEGRAML KCSQDLSSVL GGFFAVQTNG LSATLTSWSE 180
  181 YLHQETCKYI ILWITHCLNI PNSSFQTTFR NMMGKTLCSE YLNATECRDM TPVVEKYFSN 240
  241 KFDKNDPYRY IDLSILADGN QIPLGHHKIL PESSTHSLSP LINDVETPTS RTYSNTRLQH 300
  301 ILYFDNRYWK RLRKDIQNVI IPTLASSNLY KPIFCQQVVE IFNHITRSVA YMDREPQLTA 360
  361 IRECVVQLFT CPTNAKNIFE NQSFLDIVWS IIDIFKEFCK VEGGVLIWQR VQKSNLTKSY 420
  421 SISFKQGLYT VETLLSKVHD PNIPLRPKEI ISLLTLCKLF NGAWKIKRKE GEHVLHEDQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [685-1257]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NFISYLEYTT SIYSIIQTAE KVSEKSKDSI DSKLFLNAIR IISSFLGNRS LTYKLIYDSH  60
   61 EVIKFSVSHE RVAFMNPLQT MLSFLIEKVS LKDAYEALED CSDFLKISDF SLRSVVLCSQ 120
  121 IDVGFWVRNG MSVLHQASYY KNNPELGSYS RDIHLNQLAI LWERDDIPRI IYNILDRWEL 180
  181 LDWFTGEVDY QHTVYEDKIS FIIQQFIAFI YQILTERQYF KTFSSLKDRR MDQIKNSIIY 240
  241 NLYMKPLSYS KLLRSVPDYL TEDTTEFDEA LEEVSVFVEP KGLADNGVFK LKASLYAKVD 300
  301 PLKLLNLENE FESSATIIKS HLAKDKDEIA KVVLIPQVSI KQLDKDALNL GAFTRNTVFA 360
  361 KVVYKLLQVC LDMEDSTFLN ELLHLVHGIF RDDELINGKD SIPEAYLSKP ICNLLLSIAN 420
  421 AKSDVFSESI VRKADYLLEK MIMKKPNELF ESLIASFGNQ YVNDYKDKKL RQGVNLQETE 480
  481 KERKRRLAKK HQARLLAKFN NQQTKFMKEH ESEFDEQDND VDMVGEKVYE SEDFTCALCQ 540
  541 DSSSTDFFVI PAYHDHSPIF RPGNIFNPNE FMP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [1258-1556]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWDGFYNDDE KQAYIDDDVL EALKENGSCG SRKVFVSCNH HIHHNCFKRY VQKKRFSSNA  60
   61 FICPLCQTFS NCTLPLCQTS KANTGLSLDM FLESELSLDT LSRLFKPFTE ENYRTINSIF 120
  121 SLMISQCQGF DKAVRKRANF SHKDVSLILS VHWANTISML EIASRLEKPY SISFFRSREQ 180
  181 KYKTLKNILV CIMLFTFVIG KPSMEFEPYP QQPDTVWNQN QLFQYIVRSA LFSPVSLRQT 240
  241 VTEALTTFSR QFLRDFLQGL SDAEQVTKLY AKASKIGDVL KVSEQMLFAL RTISDVRME

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [1557-1826]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GLDSESIIYD LAYTFLLKSL LPTIRRCLVF IKVLHELVKD SENETLVING HEVEEELEFE  60
   61 DTAEFVNKAL KMITEKESLV DLLTTQESIV SHPYLENIPY EYCGIIKLID LSKYLNTYVT 120
  121 QSKEIKLREE RSQHMKNADN RLDFKICLTC GVKVHLRADR HEMTKHLNKN CFKPFGAFLM 180
  181 PNSSEVCLHL TQPPSNIFIS APYLNSHGEV GRNAMRRGDL TTLNLKRYEH LNRLWINNEI 240
  241 PGYISRVMGD EFRVTILSNG FLFAFNREPR 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [1827-1950]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRRIPPTDED DEDMEEGEDG FFTEGNDEMD VDDETGQAAN LFGVGAEGIA GGGVRDFFQF  60
   61 FENFRNTLQP QGNGDDDAPQ NPPPILQFLG PQFDGATIIR NTNPRNLDED DSDDNDDSDE 120
  121 REIW

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.459 a.74.1 Cyclin-like
View Download 0.359 a.177.1 Sigma2 domain of RNA polymerase sigma factors
View Download 0.263 d.96.1 Tetrahydrobiopterin biosynthesis enzymes-like
View Download 0.244 a.1.1 Globin-like
View Download 0.220 c.95.1 Thiolase-like

Predicted Domain #8
Region A:
Residues: [871-1009]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EVDYQHTVYE DKISFIIQQF IAFIYQILTE RQYFKTFSSL KDRRMDQIKN SIIYNLYMKP  60
   61 LSYSKLLRSV PDYLTEDTTE FDEALEEVSV FVEPKGLADN GVFKLKASLY AKVDPLKLLN 120
  121 LENEFESSAT IIKSHLAKD

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.35
Match: 2doaA
Description: No description for 2doaA was found.

Predicted functions:

Term Confidence Notes
hydrolase activity 2.37143167527915 bayes_pls_golite062009
nucleic acid binding 2.23450316335876 bayes_pls_golite062009
binding 2.14387047687719 bayes_pls_golite062009
DNA binding 2.04297552772596 bayes_pls_golite062009
transcription regulator activity 2.02735936435983 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.96945784119904 bayes_pls_golite062009
small conjugating protein ligase activity 1.76884421390271 bayes_pls_golite062009
transcription factor activity 1.26194702122873 bayes_pls_golite062009
acid-amino acid ligase activity 1.24657793410496 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 0.95341825085177 bayes_pls_golite062009
protein binding 0.863483803868456 bayes_pls_golite062009
sequence-specific DNA binding 0.111186019165274 bayes_pls_golite062009

Predicted Domain #9
Region A:
Residues: [1010-1156]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDEIAKVVLI PQVSIKQLDK DALNLGAFTR NTVFAKVVYK LLQVCLDMED STFLNELLHL  60
   61 VHGIFRDDEL INGKDSIPEA YLSKPICNLL LSIANAKSDV FSESIVRKAD YLLEKMIMKK 120
  121 PNELFESLIA SFGNQYVNDY KDKKLRQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #10
Region A:
Residues: [1157-1327]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVNLQETEKE RKRRLAKKHQ ARLLAKFNNQ QTKFMKEHES EFDEQDNDVD MVGEKVYESE  60
   61 DFTCALCQDS SSTDFFVIPA YHDHSPIFRP GNIFNPNEFM PMWDGFYNDD EKQAYIDDDV 120
  121 LEALKENGSC GSRKVFVSCN HHIHHNCFKR YVQKKRFSSN AFICPLCQTF S

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #11
Region A:
Residues: [1328-1554]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NCTLPLCQTS KANTGLSLDM FLESELSLDT LSRLFKPFTE ENYRTINSIF SLMISQCQGF  60
   61 DKAVRKRANF SHKDVSLILS VHWANTISML EIASRLEKPY SISFFRSREQ KYKTLKNILV 120
  121 CIMLFTFVIG KPSMEFEPYP QQPDTVWNQN QLFQYIVRSA LFSPVSLRQT VTEALTTFSR 180
  181 QFLRDFLQGL SDAEQVTKLY AKASKIGDVL KVSEQMLFAL RTISDVR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #12
Region A:
Residues: [1555-1654]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEGLDSESII YDLAYTFLLK SLLPTIRRCL VFIKVLHELV KDSENETLVI NGHEVEEELE  60
   61 FEDTAEFVNK ALKMITEKES LVDLLTTQES IVSHPYLENI 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #13
Region A:
Residues: [1655-1805]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PYEYCGIIKL IDLSKYLNTY VTQSKEIKLR EERSQHMKNA DNRLDFKICL TCGVKVHLRA  60
   61 DRHEMTKHLN KNCFKPFGAF LMPNSSEVCL HLTQPPSNIF ISAPYLNSHG EVGRNAMRRG 120
  121 DLTTLNLKRY EHLNRLWINN EIPGYISRVM G

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #14
Region A:
Residues: [1806-1950]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DEFRVTILSN GFLFAFNREP RPRRIPPTDE DDEDMEEGED GFFTEGNDEM DVDDETGQAA  60
   61 NLFGVGAEGI AGGGVRDFFQ FFENFRNTLQ PQGNGDDDAP QNPPPILQFL GPQFDGATII 120
  121 RNTNPRNLDE DDSDDNDDSD EREIW

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.459 a.74.1 Cyclin-like
View Download 0.359 a.177.1 Sigma2 domain of RNA polymerase sigma factors
View Download 0.324 a.74.1 Cyclin-like
View Download 0.263 d.96.1 Tetrahydrobiopterin biosynthesis enzymes-like
View Download 0.256 a.74.1 Cyclin-like


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle