YRC Public Data Repository - Protein Structure Prediction

Protein:	PPT1
Organism:	Saccharomyces cerevisiae
Length:	513 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PPT1.

Description	E-value	Query Range	Subject Range
HGNC:9322\|MIM:60... - phosphatase 5, catalytic subunit PPP5C - protein phosphatase 5, catalytic subunit gi\|60654849, gi\|... - gi\|60654849\|gb\|AAX31989.1\| protein phosphatase 5 catalytic subunit [synthetic construct], gi\|6065484...	0.0	[4..513]	[20..496]
gi\|16930441, gi\|... - gi\|33589766\|gb\|AAQ22649.1\| At2g42810/F7D19.19 [Arabidopsis thaliana], gi\|20197966\|gb\|AAD21727.2\| put...	0.0	[7..509]	[8..478]
gi\|2407639 - gi\|2407639\|gb\|AAB70574.1\| protein phosphatase 5; PP5 [Xenopus laevis]	0.0	[4..513]	[13..489]
PPP5_RAT - Serine/threonine-protein phosphatase 5 OS=Rattus norvegicus GN=Ppp5c PE=1 SV=1	0.0	[4..513]	[20..496]
PPP5_MOUSE - Serine/threonine-protein phosphatase 5 OS=Mus musculus GN=Ppp5c PE=2 SV=2	0.0	[4..513]	[20..496]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[4..508]	[20..491]
PPT1 - Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the n... PPT1_YEAST - Serine/threonine-protein phosphatase T OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=P...	0.0	[1..513]	[1..513]

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Predicted Domain #1

Region A:
Residues: [1-44]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTPTAADRA KALERKNEGN VFVKEKHFLK AIEKYTEAID LDST

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	262.440336
Match:	1a17__
Description:	Protein phosphatase 5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphoprotein phosphatase activity	11.6417995308386	bayes_pls_golite062009
protein serine/threonine phosphatase activity	10.6440947462013	bayes_pls_golite062009
phosphatase activity	10.5525832502704	bayes_pls_golite062009
phosphoric ester hydrolase activity	10.3702645338723	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	9.02791306892273	bayes_pls_golite062009
calcium-dependent protein serine/threonine phosphatase activity	6.04386346716682	bayes_pls_golite062009
hydrolase activity	4.67522104695122	bayes_pls_golite062009
myosin phosphatase activity	4.20017318089013	bayes_pls_golite062009
transcription regulator activity	2.36571535004008	bayes_pls_golite062009
DNA binding	1.71381351716702	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.68552051869632	bayes_pls_golite062009
kinase activity	1.67788383575784	bayes_pls_golite062009
nucleic acid binding	1.61516860680687	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.57807175808088	bayes_pls_golite062009
protein kinase activity	1.4514460578232	bayes_pls_golite062009
binding	1.44538582463569	bayes_pls_golite062009
catalytic activity	1.39852585255405	bayes_pls_golite062009
transferase activity	1.3407391509244	bayes_pls_golite062009
protein binding	1.33435965029646	bayes_pls_golite062009
transcription factor activity	1.01338808398786	bayes_pls_golite062009
protein serine/threonine kinase activity	0.66803085638835	bayes_pls_golite062009
transcription factor binding	0.518146612491969	bayes_pls_golite062009
signal transducer activity	0.474250625448338	bayes_pls_golite062009
molecular transducer activity	0.474250625448338	bayes_pls_golite062009
structural molecule activity	0.364610105488011	bayes_pls_golite062009
transcription cofactor activity	0.30464889749774	bayes_pls_golite062009
transcription activator activity	0.0593768116971065	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [45-166]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QSIYFSNRAF AHFKVDNFQS ALNDCDEAIK LDPKNIKAYH RRALSCMALL EFKKARKDLN  60
   61 VLLKAKPNDP AATKALLTCD RFIREERFRK AIGGAENEAK ISLCQTLNLS SFDANADLAN 120
  121 YE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	262.440336
Match:	1a17__
Description:	Protein phosphatase 5
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [167-513]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GPKLEFEQLY DDKNAFKGAK IKNMSQEFIS KMVNDLFLKG KYLPKKYVAA IISHADTLFR  60
   61 QEPSMVELEN NSTPDVKISV CGDTHGQFYD VLNLFRKFGK VGPKHTYLFN GDFVDRGSWS 120
  121 CEVALLFYCL KILHPNNFFL NRGNHESDNM NKIYGFEDEC KYKYSQRIFN MFAQSFESLP 180
  181 LATLINNDYL VMHGGLPSDP SATLSDFKNI DRFAQPPRDG AFMELLWADP QEANGMGPSQ 240
  241 RGLGHAFGPD ITDRFLRNNK LRKIFRSHEL RMGGVQFEQK GKLMTVFSAP NYCDSQGNLG 300
  301 GVIHVVPGHG ILQAGRNDDQ NLIIETFEAV EHPDIKPMAY SNGGFGL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	628.0
Match:	1fjmA_
Description:	Protein phosphatase-1 (PP-1)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: