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View Structure Prediction Details

Protein: SIP2
Organism: Saccharomyces cerevisiae
Length: 415 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SIP2.

Description E-value Query
Range
Subject
Range
SIP2 - One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the respo...
SIP2_YEAST - SNF1 protein kinase subunit beta-2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SIP2 ...
0.0 [1..415] [1..415]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [7..413] [15..486]
gi|119618560, gi... - gi|2439516|gb|AAB71326.1| AMP-activated protein kinase beta; 95% similar to X95577 (PID:g1185269) [H...
1.0E-85 [114..412] [23..282]
AAKB1_MOUSE - 5'-AMP-activated protein kinase subunit beta-1 OS=Mus musculus GN=Prkab1 PE=1 SV=2
4.0E-80 [114..412] [23..270]
AAKB1_RAT - 5'-AMP-activated protein kinase subunit beta-1 OS=Rattus norvegicus GN=Prkab1 PE=1 SV=4
2.0E-79 [114..412] [23..270]

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Predicted Domain #1
Region A:
Residues: [1-97]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGTTTSHPAQ KKQTTKKCRA PIMSDVREKP SNAQGCEPQE MDAVSKKVTE LSLNKCSDSQ  60
   61 DAGQPSREGS ITKKKSTLLL RDEDEPTMPK LSVMETA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.567 a.4.5 "Winged helix" DNA-binding domain
View Download 0.398 d.1.1 Microbial ribonucleases
View Download 0.433 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.409 a.7.5 Tubulin chaperone cofactor A
View Download 0.444 a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.567 a.4.5 "Winged helix" DNA-binding domain
View Download 0.444 a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.433 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.409 a.7.5 Tubulin chaperone cofactor A
View Download 0.398 d.1.1 Microbial ribonucleases
View Download 0.386 d.88.1 SRF-like
View Download 0.357 f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.345 a.64.1 Saposin
View Download 0.334 d.150.1 4'-phosphopantetheinyl transferase
View Download 0.329 d.82.2 Frataxin-like
View Download 0.328 d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.326 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.317 a.130.1 Chorismate mutase II
View Download 0.284 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.281 d.102.1 Regulatory factor Nef
View Download 0.277 a.4.5 "Winged helix" DNA-binding domain
View Download 0.255 b.9.1 Neurophysin II
View Download 0.251 a.39.1 EF-hand
View Download 0.241 a.4.1 Homeodomain-like
View Download 0.233 a.58.1 Chemotaxis receptor methyltransferase CheR, N-terminal domain
View Download 0.231 a.2.3 Chaperone J-domain
View Download 0.226 c.13.2 Anti-sigma factor antagonist SpoIIaa
View Download 0.226 d.58.17 Metal-binding domain
View Download 0.217 c.3.1 FAD/NAD(P)-binding domain
View Download 0.212 a.133.1 Phospholipase A2, PLA2
View Download 0.210 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.204 a.74.1 Cyclin-like
View Download 0.203 a.112.1 Description not found.
View Download 0.203 a.29.2 Bromodomain
View Download 0.201 a.4.1 Homeodomain-like

Predicted Domain #2
Region A:
Residues: [98-415]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VDTDSGSSST SDDEEGDIIA QTTEPKQDAS PDDDRSGHSS PREEGQQQIR AKEASGGPSE  60
   61 IKSSLMVPVE IRWQQGGSKV YVTGSFTKWR KMIGLIPDSD NNGSFHVKLR LLPGTHRFRF 120
  121 IVDNELRVSD FLPTATDQMG NFVNYIEVRQ PEKNPTNEKI RSKEADSMRP PTSDRSSIAL 180
  181 QIGKDPDDFG DGYTRFHEDL SPRPPLEYTT DIPAVFTDPS VMERYYYTLD RQQSNTDTSW 240
  241 LTPPQLPPQL ENVILNKYYA TQDQFNENNS GALPIPNHVV LNHLVTSSIK HNTLCVASIV 300
  301 RYKQKYVTQI LYTPIESS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
AMP-activated protein kinase activity 4.78975226545815 bayes_pls_golite062009
binding 2.65544526722793 bayes_pls_golite062009
voltage-gated potassium channel activity 2.18099602369564 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.66390525860632 bayes_pls_golite062009
kinase activity 1.64560031716993 bayes_pls_golite062009
cation channel activity 1.61654093209843 bayes_pls_golite062009
ligand-gated channel activity 1.56948414427108 bayes_pls_golite062009
ligand-gated ion channel activity 1.56948414427108 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.53194692728729 bayes_pls_golite062009
protein binding 1.50286160643298 bayes_pls_golite062009
gated channel activity 1.48812502999143 bayes_pls_golite062009
cation transmembrane transporter activity 1.46948685366075 bayes_pls_golite062009
protein kinase activity 1.44964326848891 bayes_pls_golite062009
transferase activity 1.26709925711174 bayes_pls_golite062009
signal transducer activity 1.12993648323166 bayes_pls_golite062009
molecular transducer activity 1.12993648323166 bayes_pls_golite062009
ion channel activity 1.10689326077049 bayes_pls_golite062009
protein serine/threonine kinase activity 0.726369450752205 bayes_pls_golite062009
cytoskeletal protein binding 0.60798225319459 bayes_pls_golite062009
actin binding 0.54002000529721 bayes_pls_golite062009
enzyme binding 0.37496592438035 bayes_pls_golite062009
inward rectifier potassium channel activity 0.252254893587557 bayes_pls_golite062009
potassium channel activity 0.0778382534131277 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle