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View Structure Prediction Details

Protein: PRE4
Organism: Saccharomyces cerevisiae
Length: 266 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRE4.

Description E-value Query
Range		 Subject
Range
PSA7L_MOUSE - Proteasome subunit alpha type-7-like OS=Mus musculus GN=Psma8 PE=1 SV=1
 3.0E-71 [6..265] [2..246]
PSA_PYRAB - Proteasome subunit alpha OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=psmA PE=3 SV=1
PSMA_PYRAB - Proteasome subunit alpha OS=Pyrococcus abyssi GN=psmA PE=3 SV=1
 5.0E-70 [5..251] [6..234]
PSA_PYRHO - Proteasome subunit alpha OS=Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC ...
PSMA_PYRHO - Proteasome subunit alpha OS=Pyrococcus horikoshii GN=psmA PE=3 SV=1
 1.0E-69 [5..251] [6..234]
PSMA7 - proteasome (prosome, macropain) subunit, alpha type, 7
gi|124126867, gi... - gi|60655637|gb|AAX32382.1| proteasome subunit alpha type 7 [synthetic construct], gi|124126867|gb|AB...
gi|21465659, gi|... - gi|21465659|pdb|1IRU|R Chain R, Crystal Structure Of The Mammalian 20s Proteasome At 2.75 A Resoluti...
 3.0E-69 [9..251] [3..229]
PSA7B_XENLA - Proteasome subunit alpha type-7-B OS=Xenopus laevis GN=psma7-b PE=2 SV=1
 4.0E-69 [9..251] [3..229]
PSA7_CARAU - Proteasome subunit alpha type-7 OS=Carassius auratus GN=psma7 PE=2 SV=1
 6.0E-69 [6..251] [2..231]
PSA_PYRFU - Proteasome subunit alpha OS=Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) GN=p...
PSMA_PYRFU - Proteasome subunit alpha OS=Pyrococcus furiosus GN=psmA PE=3 SV=1
 1.0E-68 [5..251] [6..234]

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Predicted Domain #1
Region A:
Residues: [1-266] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNHDPFSWGR PADSTYGAYN TQIANAGASP MVNTQQPIVT GTSVISMKYD NGVIIAADNL  60
   61 GSYGSLLRFN GVERLIPVGD NTVVGISGDI SDMQHIERLL KDLVTENAYD NPLADAEEAL 120
  121 EPSYIFEYLA TVMYQRRSKM NPLWNAIIVA GVQSNGDQFL RYVNLLGVTY SSPTLATGFG 180
  181 AHMANPLLRK VVDRESDIPK TTVQVAEEAI VNAMRVLYYR DARSSRNFSL AIIDKNTGLT 240
  241 FKKNLQVENM KWDFAKDIKG YGTQKI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1563.0
Match: 1g0uM_
Description: Proteasome beta subunit (catalytic)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
endopeptidase activity 6.91642761177919 bayes_pls_golite062009
peptidase activity 6.84511694091156 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 6.5973571808298 bayes_pls_golite062009
hydrolase activity 4.47652590304822 bayes_pls_golite062009
threonine-type endopeptidase activity 2.98214579292788 bayes_pls_golite062009
threonine-type peptidase activity 2.98214579292788 bayes_pls_golite062009
binding 1.75265921676176 bayes_pls_golite062009
nucleic acid binding 1.39216781236247 bayes_pls_golite062009
catalytic activity 1.19663085909195 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle