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View Structure Prediction Details

Protein: SSA4
Organism: Saccharomyces cerevisiae
Length: 642 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SSA4.

Description E-value Query
Range
Subject
Range
HSP70_TRIRU - Heat shock 70 kDa protein OS=Trichophyton rubrum GN=HSP70 PE=2 SV=1
0.0 [1..642] [1..654]
gi|6969976 - gi|6969976|gb|AAF34134.1| high molecular weight heat shock protein [Malus x domestica]
0.0 [2..642] [7..650]
gi|2894792, gi|1... - gi|2894792|gb|AAC02807.1| heat shock protein 70 [Cryptosporidium parvum], gi|1616783|gb|AAB16853.1| ...
0.0 [2..611] [6..617]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [2..642] [6..641]
HSP70_TRYCR - Heat shock 70 kDa protein OS=Trypanosoma cruzi GN=HSP70 PE=3 SV=1
0.0 [4..610] [6..615]
HSP70_LEIDO - Heat shock 70 kDa protein OS=Leishmania donovani GN=HSP70 PE=3 SV=1
0.0 [4..642] [6..653]
HSP7C_ICTPU - Heat shock cognate 71 kDa protein OS=Ictalurus punctatus GN=hsc70 PE=2 SV=1
0.0 [2..611] [4..613]
gi|1620381 - gi|1620381|emb|CAA69891.1| 70 kD heat shock protein [Takifugu rubripes]
0.0 [2..522] [6..526]

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Predicted Domain #1
Region A:
Residues: [1-173]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKAVGIDLG TTYSCVAHFA NDRVEIIAND QGNRTTPSYV AFTDTERLIG DAAKNQAAMN  60
   61 PHNTVFDAKR LIGRKFDDPE VTNDAKHYPF KVIDKGGKPV VQVEYKGETK TFTPEEISSM 120
  121 ILTKMKETAE NFLGTEVKDA VVTVPAYFND SQRQATKDAG TIAGLNVLRI INE

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [364-381]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DEAVAYGAAV QAAILTGD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2750.0
Match: 1hjoA_
Description: Heat shock protein 70kDa, ATPase fragment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
unfolded protein binding 7.97191512372019 bayes_pls_golite062009
structural molecule activity 3.59589495899762 bayes_pls_golite062009
structural constituent of cytoskeleton 2.46121037473545 bayes_pls_golite062009
carbohydrate kinase activity 2.33338276303563 bayes_pls_golite062009
cytoskeletal protein binding 2.20983242331685 bayes_pls_golite062009
binding 2.11855816699924 bayes_pls_golite062009
protein binding 2.00711904074672 bayes_pls_golite062009
hydrolase activity 1.88613511243568 bayes_pls_golite062009
hexokinase activity 1.70516840340504 bayes_pls_golite062009
transcription regulator activity 1.68670098354938 bayes_pls_golite062009
nucleic acid binding 1.43834016708999 bayes_pls_golite062009
peptidase activity 1.4127499531612 bayes_pls_golite062009
DNA binding 1.36804228074586 bayes_pls_golite062009
transporter activity 1.2883466875237 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.16749728168925 bayes_pls_golite062009
kinase activity 1.11102445353265 bayes_pls_golite062009
actin binding 1.03829083423378 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.953663805249074 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.900931843471417 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.898645342556399 bayes_pls_golite062009
pyrophosphatase activity 0.875671218597808 bayes_pls_golite062009
substrate-specific transporter activity 0.796517590178929 bayes_pls_golite062009
transcription factor activity 0.783439770973386 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.78242344952806 bayes_pls_golite062009
protein transporter activity 0.780308299678282 bayes_pls_golite062009
ATPase activity 0.687771333492666 bayes_pls_golite062009
myosin binding 0.607451856096 bayes_pls_golite062009
glucose binding 0.53527958884988 bayes_pls_golite062009
glucokinase activity 0.47468456642723 bayes_pls_golite062009
catalytic activity 0.296484721581333 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.186218331473028 bayes_pls_golite062009
chromatin binding 0.155140608043269 bayes_pls_golite062009
protease binding 0.121259015422625 bayes_pls_golite062009
chaperone binding 0.00111313452804307 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [174-229]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTAAAIAYGL DKKSQKEHNV LIFDLGGGTF DVSLLSIDEG VFEVKATAGD THLGGE

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [305-363]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADLFRSTLEP VEKVLADSKL DKSQIDEIVL VGGSTRIPKV QKLVSDFFNG KEPNRSINP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2750.0
Match: 1hjoA_
Description: Heat shock protein 70kDa, ATPase fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [230-304]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DFDSRLVNFL AEEFKRKNKK DLTTNQRSLR RLRTAAERAK RTLSSSAQTS IEIDSLFEGI  60
   61 DFYTSITRAR FEELC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2750.0
Match: 1hjoA_
Description: Heat shock protein 70kDa, ATPase fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [382-554]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QSSTTQDLLL LDVAPLSLGI ETAGGIMTKL IPRNSTIPTK KSEVFSTYAD NQPGVLIQVF  60
   61 EGERTRTKDN NLLGKFELSG IPPAPRGVPQ IEVTFDIDAN GILNVSAVEK GTGKSNKITI 120
  121 TNDKGRLSKE DIDKMVAEAE KFKAEDEQEA QRVQAKNQLE SYAFTLKNSV SEN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 740.08661
Match: 1ckrA_
Description: DnaK
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [555-642]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NFKEKVGEED ARKLEAAAQD AINWLDASQA ASTEEYKERQ KELEGVANPI MSKFYGAAGG  60
   61 APGAGPVPGA GAGPTGAPDN GPTVEEVD

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.5
Match: 1dkxA
Description: DnaK
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle