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View Structure Prediction Details

Protein: AST2
Organism: Saccharomyces cerevisiae
Length: 430 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AST2.

Description E-value Query
Range		 Subject
Range
ADHX_SPAAU - Alcohol dehydrogenase class-3 OS=Sparus aurata PE=2 SV=1
 0.0 [43..424] [3..374]
ADHX_SAAHA - Alcohol dehydrogenase class-3 OS=Saara hardwickii PE=1 SV=1
 0.0 [47..424] [4..371]
gi|2570190 - gi|2570190|dbj|BAA22979.1| alcohol dehydrogenase [Arabidopsis thaliana]
 0.0 [42..427] [2..377]
gi|6684357 - gi|6684357|gb|AAF23539.1|AF110441_1 alcohol dehydrogenase [Halimolobos perplexa var. lemhiensis]
 0.0 [42..427] [2..377]
ADHX_ORYSJ - Alcohol dehydrogenase class-3 OS=Oryza sativa subsp. japonica GN=Os02g0815500 PE=2 SV=1
ADHX_ORYSA - Alcohol dehydrogenase class 3 (EC 1.1.1.1) (Alcohol dehydrogenase class III) (S-(hydroxymethyl)gluta...
 0.0 [40..429] [2..381]
ADHH_GADMO - Alcohol dehydrogenase class-3 chain H OS=Gadus morhua PE=1 SV=1
 0.0 [42..424] [1..373]

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Predicted Domain #1
Region A:
Residues: [1-210] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEKILENKD PKLEAMTVDH EVSAPKPIPV DEPTLTRVAR PLRHVRHIPV KSLVFHSKHG  60
   61 PITFSYENKI KLPISKNKLV VQVNYVGLNP VDMKIRNGYT KPIYGEAGIG REYSGVITHV 120
  121 GDNLTNRWNV GDDVYGIYYH PKLAIGALQS SLLIDPRVDP ILMRPKNTLS PEKAAGSLFC 180
  181 LGTALNLLAQ LKEKDQLNTE SNVLINGGTS

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [359-430] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WSYDYSHFYF DPNIKIIPKK NDWIHECGKL LNEGVVDCVV DKVYSWKNFK EAFSYMATQR  60
   61 AQGKLIMKVE GF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 125.0
Match: 1tehA_
Description: Alcohol dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
oxidoreductase activity 4.14217990101505 bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors 2.13774251017711 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1.96417104841008 bayes_pls_golite062009
catalytic activity 1.79741889688267 bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity 1.68027744358887 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor 1.22416351603098 bayes_pls_golite062009
chaperone binding 1.19079350615542 bayes_pls_golite062009
DNA binding 1.02274180655721 bayes_pls_golite062009
transcription regulator activity 0.955628854752953 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 0.905392379451071 bayes_pls_golite062009
nucleic acid binding 0.901776352952123 bayes_pls_golite062009
alcohol dehydrogenase activity, zinc-dependent 0.839863523675468 bayes_pls_golite062009
transporter activity 0.793769336118517 bayes_pls_golite062009
structural molecule activity 0.75267483298133 bayes_pls_golite062009
ligase activity 0.742884668104576 bayes_pls_golite062009
transmembrane transporter activity 0.635891484075352 bayes_pls_golite062009
substrate-specific transporter activity 0.555188550031886 bayes_pls_golite062009
binding 0.553666136934364 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH 0.51503848775098 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.410307505174239 bayes_pls_golite062009
transcription factor activity 0.368443846770004 bayes_pls_golite062009
ion transmembrane transporter activity 0.29802814097478 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 0.261132005311306 bayes_pls_golite062009
active transmembrane transporter activity 0.239024094835991 bayes_pls_golite062009
cation transmembrane transporter activity 0.212092278332619 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.113340150368917 bayes_pls_golite062009
pyrophosphatase activity 0.0696058100530442 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.0591634687578807 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0560606007580392 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [211-358] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVGMFAIQLL KRYYKVSKKL VVVTSGNGAA VLSEHFPDLK DEIIFINYLS CRGKSSKPLR  60
   61 RMLDTGKVVD YDDFNTLKET EDYTQGKFNV VLDFIGGYDI LSHSSSLIHA KGAYITTVGD 120
  121 YVGNYKKDVF DSWDNPSANA RKMFGSML

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 125.0
Match: 1tehA_
Description: Alcohol dehydrogenase
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle