YRC Public Data Repository - Protein Structure Prediction

Protein:	YEL020C
Organism:	Saccharomyces cerevisiae
Length:	560 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YEL020C.

Description	E-value	Query Range	Subject Range
gi\|7436698 - pir\|\|C70341 acetolactate synthase (EC 4.1.3.18) large chain - Aquifex aeolicus gi\|15605942, gi\|... - gi\|2983101\|gb\|AAC06706.1\| acetolactate synthase large subunit [Aquifex aeolicus VF5], gi\|15605942\|re...	0.0	[4..547]	[5..553]
Q66EL8\|Q66EL8_YERPS - Acetolactate synthase III, valine sensitive, large subunit FAD and thiamine PPi binding - Yersinia p... gi\|77631655, gi\|... - gi\|77631655\|ref\|ZP_00794241.1\| COG0028: Thiamine pyrophosphate-requiring enzymes [acetolactate synth... gi\|161511301 - gi\|161511301\|ref\|NP_994917.2\| acetolactate synthase 3 catalytic subunit [Yersinia pestis biovar Micr... gi\|161484748 - gi\|161484748\|ref\|NP_670937.2\| acetolactate synthase 3 catalytic subunit [Yersinia pestis KIM] gi\|186894031, gi... - gi\|186894031\|ref\|YP_001871143.1\| acetolactate synthase 3 catalytic subunit [Yersinia pseudotuberculo... gi\|169752280, gi... - gi\|170025746\|ref\|YP_001722251.1\| acetolactate synthase 3 catalytic subunit [Yersinia pseudotuberculo... gi\|229837069, gi... - gi\|229837069\|ref\|ZP_04457234.1\| acetolactate synthase isozyme III large subunit [Yersinia pestis Pes... gi\|150260425, gi... - gi\|150260425\|ref\|ZP_01917153.1\| acetolactate synthase isozyme III large subunit [Yersinia pestis CA8... gi\|229696794, gi... - gi\|229840428\|ref\|ZP_04460587.1\| acetolactate synthase isozyme III large subunit [Yersinia pestis bio... gi\|229843030, gi... - gi\|229843030\|ref\|ZP_04463180.1\| acetolactate synthase isozyme III large subunit [Yersinia pestis bio... gi\|89104759 - gi\|89104759\|ref\|ZP_01177293.1\| COG0028: Thiamine pyrophosphate-requiring enzymes [acetolactate synth... gi\|108809551, gi... - gi\|108809551\|ref\|YP_653467.1\| acetolactate synthase 3 catalytic subunit [Yersinia pestis Antiqua], g... gi\|77633509 - gi\|77633509\|ref\|ZP_00795637.1\| COG0028: Thiamine pyrophosphate-requiring enzymes [acetolactate synth... gi\|229682102, gi... - gi\|229900763\|ref\|ZP_04515887.1\| acetolactate synthase isozyme III large subunit [Yersinia pestis Nep... gi\|25291303 - pir\|\|AI0066 acetolactate synthase (EC 4.1.3.18) isozyme III large chain [imported] - Yersinia pestis... gi\|218927736, gi... - gi\|218927736\|ref\|YP_002345611.1\| acetolactate synthase 3 catalytic subunit [Yersinia pestis CO92], g... gi\|51588307, gi\|... - gi\|51595025\|ref\|YP_069216.1\| acetolactate synthase 3 catalytic subunit [Yersinia pseudotuberculosis ...	0.0	[1..558]	[1..572]
gi\|6478282 - gi\|6478282\|gb\|AAF13791.1\|AF129502_2 acetohydroxy acid synthase large subunit [Buchnera aphidicola] ILVI_BUCSC - Acetolactate synthase large subunit OS=Buchnera aphidicola subsp. Schlechtendalia chinensis GN=ilvI ...	0.0	[1..560]	[1..566]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[1..558]	[31..601]
ILVI_BUCAP - Acetolactate synthase large subunit OS=Buchnera aphidicola subsp. Schizaphis graminum GN=ilvI PE=3 S... ILVI_BUCAP - Acetolactate synthase large subunit OS=Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) GN... gi\|3435164 - gi\|3435164\|gb\|AAC32333.1\| acetohydroxy acid synthase large subunit [Buchnera aphidicola]	0.0	[3..560]	[4..563]
gi\|25291271 - pir\|\|A85490 hypothetical protein ilvI [imported] - Escherichia coli (strain O157:H7, substrain EDL9... gi\|12512777, gi\|... - gi\|15799761\|ref\|NP_285773.1\| acetolactate synthase III large subunit [Escherichia coli O157:H7 EDL93...	0.0	[1..558]	[29..599]
gi\|7436700 - pir\|\|C69059 acetolactate synthase (EC 4.1.3.18) large chain - Methanobacterium thermoautotrophicum (... gi\|15679441, gi\|... - gi\|2622556\|gb\|AAB85919.1\| acetolactate synthase, large subunit [Methanothermobacter thermautotrophic...	0.0	[3..550]	[4..543]
gi\|17232105, gi\|... - gi\|17232105\|ref\|NP_488653.1\| acetolactate synthase 3 catalytic subunit [Nostoc sp. PCC 7120], gi\|171... gi\|25291313 - pir\|\|AE2382 acetohydroxy acid synthase [imported] - Nostoc sp. (strain PCC 7120)	0.0	[2..558]	[32..591]
ILVI_HAEIN - Acetolactate synthase large subunit OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 ... ILVI_HAEIN - Acetolactate synthase large subunit OS=Haemophilus influenzae GN=ilvI PE=3 SV=1 gi\|145273548, gi... - gi\|145641734\|ref\|ZP_01797310.1\| acetolactate synthase III large subunit [Haemophilus influenzae R302... gi\|145641734 - gi\|145641734\|ref\|ZP_01797310.1\| acetolactate synthase III large subunit [Haemophilus influenzae R302...	0.0	[2..560]	[3..563]

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Predicted Domain #1

Region A:
Residues: [1-185]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTTATQHFA QLLQKYGIDT VFGIVGIPIV QLADTMVANG IKFIPCRNEQ AASYAASAYG  60
   61 YISDKPGVLL IVGGPGLIHA LAGIYNSMSN RWPLLVIAGS SSQSDIHKGG FQELDQVSLL 120
  121 SPFLKFTGKL TPDNIDMITQ KALNYCIQGT AGVSYIDVPA DFIEYEKPLE GNDRTGNELP 180
  181 MILTP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	408.0103
Match:	1powA_
Description:	Pyruvate oxidase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
acetolactate synthase activity	12.903449876837	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	12.3239025230705	bayes_pls_golite062009
pyruvate dehydrogenase activity	5.28857071459273	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	5.21233670052586	bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity	5.08663245333808	bayes_pls_golite062009
transketolase activity	2.50501741089295	bayes_pls_golite062009
catalytic activity	2.25537597692103	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	2.15444163802756	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	1.98546381612935	bayes_pls_golite062009
thiamin pyrophosphate binding	1.87247313698582	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	1.82969293063325	bayes_pls_golite062009
deoxyhypusine synthase activity	1.46517585302326	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	1.0611726850452	bayes_pls_golite062009
protein deacetylase activity	0.882978552120903	bayes_pls_golite062009
histone deacetylase activity	0.881399086357632	bayes_pls_golite062009
cation transmembrane transporter activity	0.78591260444574	bayes_pls_golite062009
hydrolase activity	0.536729211484905	bayes_pls_golite062009
ion transmembrane transporter activity	0.51426028502998	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	0.492590326775569	bayes_pls_golite062009
oxidoreductase activity	0.459800433209317	bayes_pls_golite062009
transferase activity	0.413024577830522	bayes_pls_golite062009
NAD-dependent histone deacetylase activity	0.38348854354211	bayes_pls_golite062009
NAD-dependent protein deacetylase activity	0.38348854354211	bayes_pls_golite062009
deacetylase activity	0.382228826641711	bayes_pls_golite062009
binding	0.313299160093284	bayes_pls_golite062009
transcription regulator activity	0.217707914161459	bayes_pls_golite062009
nucleic acid binding	0.0424046736878951	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [186-354]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NICGPDPSKI KKVVQLILQH KNKNILIVIG KGAVKNSHEI RRLVNTFNLP FLPTPMAKGI  60
   61 VPDSSPLNVS SARSQALKIA DIVLVLGARL NWILHFGTSP KWNSESIFIQ FDSNPETLGD 120
  121 NNVSPGADLS IWGDIGLSVT ALVEELTRQD SCWKYSGVKQ EIREKIQLN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	408.0103
Match:	1powA_
Description:	Pyruvate oxidase
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [355-560]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QTRLLRKEKT RGAQLNYNQV YGTLRPLIDD YRTILVTEGA NTMDIARISF PTDAPRRRLD  60
   61 AGTNATMGIG LGYALACKAS HPELDVVLIQ GDSAFGFSAM EIETAVRCQL ALVIVVMNNS 120
  121 GIYHGEKDIE GDLPPTALSK NCRYDLVGKG LGANDFFVNT ISELSRCFQQ AVQLSRTKRE 180
  181 TSVINVIIEP GEQKQIAFAW QNKPRL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	408.0103
Match:	1powA_
Description:	Pyruvate oxidase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: