YRC Public Data Repository - Protein Structure Prediction

Protein:	FPR2
Organism:	Saccharomyces cerevisiae
Length:	135 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FPR2.

Description	E-value	Query Range	Subject Range
gi\|151942480 - gi\|151942480\|gb\|EDN60836.1\| PPIase [Saccharomyces cerevisiae YJM789] FPR2 - Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin;... FKBP2_YEAST - Peptidyl-prolyl cis-trans isomerase FPR2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN... gi\|190404563 - gi\|190404563\|gb\|EDV07830.1\| FK506-binding protein 2 precursor [Saccharomyces cerevisiae RM11-1a]	6.0E-42	[1..135]	[1..135]
gi\|7428434 - pir\|\|S75144 FKBP-type peptidyl-prolyl cis-trans isomerase - Synechocystis sp. (strain PCC 6803) gi\|16329650, gi\|... - gi\|1652134\|dbj\|BAA17058.1\| FKBP-type peptidyl-prolyl cis-trans isomerase [Synechocystis sp. PCC 6803...	2.0E-39	[17..132]	[87..201]
gi\|17228073, gi\|... - gi\|17228073\|ref\|NP_484621.1\| FKBP-type peptidyl-prolyl cis-trans isomerase [Nostoc sp. PCC 7120], gi... gi\|25292526 - pir\|\|AH1878 FKBP-type peptidyl-prolyl cis-trans isomerase [imported] - Nostoc sp. (strain PCC 7120)	2.0E-39	[10..132]	[45..165]
gi\|220943670, gi... - gi\|220953604\|gb\|ACL89345.1\| Fkbp13-PA [synthetic construct], gi\|220943670\|gb\|ACL84378.1\| Fkbp13-PA [... FBpp0309698, Fkb... - The gene Fkbp13 is referred to in FlyBase by the symbol Dmel\Fkbp13 (CG9847, FBgn0010470). It is a p...	3.0E-38	[1..134]	[1..135]
gi\|14270308 - gi\|14270308\|emb\|CAC39452.1\| immunophilin FKBP-52 [Mus musculus]	6.0E-38	[24..132]	[25..133]
gi\|2231756 - gi\|2231756\|gb\|AAC45711.1\| macrophage infectivity potentiator [Legionella wadsworthii]	1.0E-37	[9..135]	[110..233]
gi\|17427796 - gi\|17427796\|emb\|CAD14486.1\| probable fkbp-type peptidyl-prolyl cis-trans isomerase (ppiase)(immunoph... gi\|17545503 - gi\|17545503\|ref\|NP_518905.1\| FKBP-type peptidyl-prolyl cis-trans isomerase [Ralstonia solanacearum G...	2.0E-37	[20..131]	[3..117]
gi\|123994911, gi... - gi\|60655019\|gb\|AAX32073.1\| FK506 binding protein 2 [synthetic construct], gi\|60655017\|gb\|AAX32072.1\|... FKBP2 - FK506 binding protein 2, 13kDa	2.0E-37	[1..133]	[1..138]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	3.0E-37	[2..132]	[3..129]

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Predicted Domain #1

Region A:
Residues: [1-135]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMFNIYLFVT FFSTILAGSL SDLEIGIIKR IPVEDCLIKA MPGDKVKVHY TGSLLESGTV  60
   61 FDSSYSRGSP IAFELGVGRV IKGWDQGVAG MCVGEKRKLQ IPSSLAYGER GVPGVIPPSA 120
  121 DLVFDVELVD VKSAA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	266.37734
Match:	1yat__
Description:	Calcineurin (FKBP12.6)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
peptidyl-prolyl cis-trans isomerase activity	4.0615867467963	bayes_pls_golite062009
cis-trans isomerase activity	3.99265212272703	bayes_pls_golite062009
macrolide binding	2.8097578502972	bayes_pls_golite062009
FK506 binding	2.69770241359364	bayes_pls_golite062009
isomerase activity	2.31710030777753	bayes_pls_golite062009
binding	1.48382710721672	bayes_pls_golite062009
transcription regulator activity	1.30296015727078	bayes_pls_golite062009
catalytic activity	0.885282592863018	bayes_pls_golite062009
intracellular ligand-gated calcium channel activity	0.753553267055211	bayes_pls_golite062009
ryanodine-sensitive calcium-release channel activity	0.753553267055211	bayes_pls_golite062009
unfolded protein binding	0.27473817613726	bayes_pls_golite062009
drug binding	0.271484008777704	bayes_pls_golite062009
protein binding	0.244588415454215	bayes_pls_golite062009
histone binding	0.221748741603068	bayes_pls_golite062009
transcription elongation regulator activity	0.21145105012677	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: