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View Structure Prediction Details

Protein: RGA2
Organism: Saccharomyces cerevisiae
Length: 1009 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RGA2.

Description E-value Query
Range		 Subject
Range
RGA2_YEAST - Rho-type GTPase-activating protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RGA...
RGA2 - GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of se...
gi|190404685 - gi|190404685|gb|EDV07952.1| rho-GTPase Activating protein [Saccharomyces cerevisiae RM11-1a]
 0.0 [1..1009] [1..1009]
rga4 - GTPase activating protein Rga4
RGA4_SCHPO - Probable Rho-type GTPase-activating protein 4 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843)...
 0.0 [1..1006] [12..932]
RHG12_MACFA - Rho GTPase-activating protein 12 OS=Macaca fascicularis GN=ARHGAP12 PE=2 SV=1
 0.0 [177..1006] [96..845]
MYO9A_RAT - Unconventional myosin-IXa OS=Rattus norvegicus GN=Myo9a PE=1 SV=1
 0.0 [189..1002] [1478..2315]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [38..1006] [8..891]
gi|7657353, gi|6... - gi|7657353|ref|NP_056557.1| myosin IXb [Mus musculus], gi|6002741|gb|AAF00118.1|AF143683_1 unconvent...
 0.0 [274..1002] [1080..1842]

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Predicted Domain #1
Region A:
Residues: [1-70] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSADPINDQS SLCVRCNKSI ASSQVYELES KKWHDQCFTC YKCDKKLNAD SDFLVLDIGT  60
   61 LICYDCSDKC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 38.228787
Match: 1b8tA_
Description: Cysteine-rich (intestinal) protein, CRP, CRIP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.53476602786095 bayes_pls_golite062009
cytoskeletal protein binding 2.31497455728997 bayes_pls_golite062009
actin binding 2.12981903473593 bayes_pls_golite062009
transcription regulator activity 1.49086416765132 bayes_pls_golite062009
protein binding 1.39455913713025 bayes_pls_golite062009
DNA binding 1.27439935466101 bayes_pls_golite062009
nucleic acid binding 1.07089120477749 bayes_pls_golite062009
receptor activity 1.05205471090697 bayes_pls_golite062009
actin filament binding 0.924007456077191 bayes_pls_golite062009
transcription factor activity 0.73645718855149 bayes_pls_golite062009
sequence-specific DNA binding 0.00178877672043032 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [71-149] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TNCGDKIDDT AIILPSSNEA YCSNCFRCCR CSNRIKNLKY AKTKRGLCCM DCHEKLLRKK  60
   61 QLLLENQTKN SSKEDFPIK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 38.228787
Match: 1b8tA_
Description: Cysteine-rich (intestinal) protein, CRP, CRIP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 2.61981913117676 bayes_pls_golite062009
binding 2.59846425523141 bayes_pls_golite062009
DNA binding 2.33064128336595 bayes_pls_golite062009
cytoskeletal protein binding 2.1457670954804 bayes_pls_golite062009
nucleic acid binding 2.11285031339066 bayes_pls_golite062009
actin binding 2.03209305727522 bayes_pls_golite062009
transcription factor activity 1.89582335878776 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
actin filament binding 0.81690252782831 bayes_pls_golite062009
sequence-specific DNA binding 0.78609133101699 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.42661918396987 bayes_pls_golite062009
transcription repressor activity 0.24744905965946 bayes_pls_golite062009
G-protein coupled receptor activity 0.156446003827888 bayes_pls_golite062009
transcription activator activity 0.0526130265453202 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [150-225] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPERSVKRPL SPTRINGKSD VSTNNTAISK NLVSSNEDQQ LTPQVLVSQE RDESSLNDNN  60
   61 DNDNSKDREE TSSHAR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.154902
Match: 1bw5__
Description: Insulin gene enhancer protein isl-1
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [226-580] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TVSIDDILNS TLEHDSNSIE EQSLVDNEDY INKMGEDVTY RLLKPQRANR DSIVVKDPRI  60
   61 PNSNSNANRF FSIYDKEETD KDDTDNKENE IIVNTPRNST DKITSPLNSP MAVQMNEEVE 120
  121 PPHGLALTLS EATKENNKSS QGIQTSTSKS MNHVSPITRT DTVEMKTSTS SSTLRLSDNG 180
  181 SFSRPQTADN LLPHKKVAPS PNKKLSRSFS LKSKNFVHNL KSKTSEMLDP KHPHHSTSIQ 240
  241 ESDTHSGWGV SSTHTNIRKS KAKKNPVSRG QSDSTIYNTL PQHGNFTVPE FNHKKAQSSL 300
  301 GSISKKQNSN DTATNRRING SFTSSSSGHH IAMFRTPPLE SGPLFKRPSL SSESA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [581-725] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HHRSSSLQTS RSTNALLEDD STKVDATDES ATSLEKDFYF TELTLRKLKL DVRELEGTKK  60
   61 KLLQDVENLR LAKERLLNDV DNLTREKDKQ SASSRESLEQ KENIATSITV KSPSSNSDRK 120
  121 GSISNASPKP RFWKIFSSAK DHQVG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.898 0.023 pheromone-dependent signal transduction involved in conjugation with cellular fusion a.24.14 FAT domain of focal adhesion kinase

Predicted Domain #6
Region A:
Residues: [726-879] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLESQQRSPN SSSGGTTNIA QKEISSPKLI RVHDELPSPG KVPLSPSPKR LDYTPDGSHL  60
   61 YGSSLQARCA YEKSTVPIII RCCIDRIEKD DIGLNMEGLY RKSGSQTLVE EIENEFAQNN 120
  121 SLHSDTLSPK LNALLNQDIH AVASVLKRYL RKLP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 193.30103
Match: 1rgp__
Description: p50 RhoGAP domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
Rho GTPase activator activity 4.58620967349979 bayes_pls_golite062009
cytoskeletal protein binding 3.42802398019084 bayes_pls_golite062009
Rac GTPase activator activity 3.29568423512865 bayes_pls_golite062009
actin binding 3.13452682535963 bayes_pls_golite062009
GTPase regulator activity 2.70614727793157 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 2.68579854252375 bayes_pls_golite062009
binding 2.36195429973813 bayes_pls_golite062009
microfilament motor activity 2.30141000926447 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 2.06038764955701 bayes_pls_golite062009
motor activity 2.04743766323523 bayes_pls_golite062009
enzyme regulator activity 1.9750017471254 bayes_pls_golite062009
small GTPase regulator activity 1.95738547986197 bayes_pls_golite062009
diacylglycerol binding 1.75824354852133 bayes_pls_golite062009
tubulin binding 1.56332747753627 bayes_pls_golite062009
actin filament binding 1.49148700086734 bayes_pls_golite062009
protein binding 1.29100556128076 bayes_pls_golite062009
Ras GTPase activator activity 1.09070479183477 bayes_pls_golite062009
actin-dependent ATPase activity 1.07737775291413 bayes_pls_golite062009
Ras guanyl-nucleotide exchange factor activity 0.958295643211986 bayes_pls_golite062009
myosin heavy chain kinase activity 0.847021935833721 bayes_pls_golite062009
GTPase activator activity 0.717730683557543 bayes_pls_golite062009
microtubule binding 0.648232426961013 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.36751853312336 bayes_pls_golite062009
transcription regulator activity 0.348246993470003 bayes_pls_golite062009
Rho GTPase binding 0.33949271618205 bayes_pls_golite062009
enzyme activator activity 0.298334474872045 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [880-1009] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPVLSFSIYD ALIDLVRNNQ LIERLPLNND KFLDSPQKVT IYEMVLKSLL EIFKILPVEH  60
   61 QEVLKVLAAH IGKVRRCSER NLMNLHNLSL VFAPSLIHDF DGEKDIVDMK ERNYIVEFIL 120
  121 GNYRDIFKQA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 193.30103
Match: 1rgp__
Description: p50 RhoGAP domain
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle