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View Structure Prediction Details

Protein: SPC110
Organism: Saccharomyces cerevisiae
Length: 944 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPC110.

Description E-value Query
Range		 Subject
Range
MYH4_PIG - Myosin-4 OS=Sus scrofa GN=MYH4 PE=2 SV=1
 0.0 [4..924] [993..1910]
MYH4_RABIT - Myosin-4 OS=Oryctolagus cuniculus GN=MYH4 PE=1 SV=1
 0.0 [4..924] [994..1911]
gi|9800488, gi|1... - gi|9800488|gb|AAF99315.1|AF272034_1 fast myosin heavy chain isoform 3 [Gallus gallus], gi|165973976|...
 0.0 [4..924] [996..1913]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [4..932] [10..935]
MYH2_BOVIN - Myosin-2 OS=Bos taurus GN=MYH2 PE=2 SV=1
 0.0 [4..924] [996..1913]

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Predicted Domain #1
Region A:
Residues: [1-77] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDEASHLPNG SLKNMEFTPV GFIKSKRNTT QTQVVSPTKV PNANNGDENE GPVKKRQRRS  60
   61 IDDTIDSTRL FSEASQF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [78-409] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDSFPEIKAN IPPSPRSGNV DKSRKRNLID DLKKDVPMSQ PLKEQEVREH QMKKERFDRA  60
   61 LESKLLGKRH ITYANSDISN KELYINEIKS LKHEIKELRK EKNDTLNNYD TLEEETDDLK 120
  121 NRLQALEKEL DAKNKIVNSR KVDDHSGCIE EREQMERKLA ELERKLKTVK DQVLELENNS 180
  181 DVQSLKLRSK EDELKNLMNE LNELKSNAEE KDTQLEFKKN ELRKRTNELN ELKIKSDEMD 240
  241 LQLKQKQNES KRLKDELNEL ETKFSENGSQ SSAKENELKM LKNKIAELEE EISTKNSQLI 300
  301 AKEGKLASLM AQLTQLESKL NQRDSQLGSR EE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 63.68867
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [410-478] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELKKTNDKLQ KDIRIAREET VSKDERIIDL QKKVKQLEND LFVIKKTHSE SKTITDNELE  60
   61 SKDKLIKIL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.39794
Match: 2tmaA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [479-649] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENDLKVAQEK YSKMEKELKE REFNYKISES KLEDEKTTLN EKISNLAAEN SQLKNKIEDN  60
   61 STATHHMKEN YEKQLESLRK DIEEYKESAK DSEDKIEELK IRIAENSAKV SEKRSKDIKQ 120
  121 KDEQISDLTQ NLKLQEDEIS SLKSIIDRYK KDFNQLKSEQ SNIQHDLNLQ I

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 14.1
Match: 1hciA
Description: alpha-actinin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.87991790206998 bayes_pls_golite062009
cytoskeletal protein binding 2.1457670954804 bayes_pls_golite062009
transcription regulator activity 2.122580758085 bayes_pls_golite062009
DNA binding 1.98453325263719 bayes_pls_golite062009
nucleic acid binding 1.93681952439958 bayes_pls_golite062009
actin binding 1.48871115327078 bayes_pls_golite062009
transcription factor activity 1.36872096268289 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.09150919349912 bayes_pls_golite062009
sequence-specific DNA binding 1.03881604759993 bayes_pls_golite062009
protein binding 1.03780839342631 bayes_pls_golite062009
chromatin binding 0.545627011042409 bayes_pls_golite062009
actin filament binding 0.26311995282891 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.18367441245103 bayes_pls_golite062009
transcription activator activity 0.174325083775401 bayes_pls_golite062009
transcription factor binding 0.14097776282047 bayes_pls_golite062009
centromeric DNA binding 0.09491254824772 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [650-847] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LNLENKLIES EDELKSLRDS QKIEIENWKR KYNNLSLEND RLLTEKESAS DKEREISILN  60
   61 RKLDEMDKEK WNLQESKEKY KRELQKVITA NDRLRREKEE LNENSNNIRI MEDKMTRIKK 120
  121 NYLSEITSLQ EENRRLEERL ILNERRKDND STMQLNDIIS YYKLKYHSEV RHNNDLKVIN 180
  181 DYLNKVLALG TRRLRLDT

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 14.1
Match: 1hciA
Description: alpha-actinin
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [848-944] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKGEHSLNIS LPDDDELDRD YYNSHVYTRY HDYEYPLRFN LNRRGPYFER RLSFKTVALL  60
   61 VLACVRMKRI AFYRRSDDNR LRILRDRIES SSGRISW

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.609 0.961 central plaque of spindle pole body a.39.1 EF-hand

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle