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View Structure Prediction Details

Protein: SPC110
Organism: Saccharomyces cerevisiae
Length: 944 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPC110.

Description E-value Query
Range		 Subject
Range
MYH4_PIG - Myosin-4 OS=Sus scrofa GN=MYH4 PE=2 SV=1
 0.0 [4..924] [993..1910]
MYH4_RABIT - Myosin-4 OS=Oryctolagus cuniculus GN=MYH4 PE=1 SV=1
 0.0 [4..924] [994..1911]
gi|9800488, gi|1... - gi|9800488|gb|AAF99315.1|AF272034_1 fast myosin heavy chain isoform 3 [Gallus gallus], gi|165973976|...
 0.0 [4..924] [996..1913]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [4..932] [10..935]
MYH2_BOVIN - Myosin-2 OS=Bos taurus GN=MYH2 PE=2 SV=1
 0.0 [4..924] [996..1913]

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Predicted Domain #1
Region A:
Residues: [1-77] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDEASHLPNG SLKNMEFTPV GFIKSKRNTT QTQVVSPTKV PNANNGDENE GPVKKRQRRS  60
   61 IDDTIDSTRL FSEASQF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 SCOP
Match		 SCOP Description
View Download 0.542 d.58.7 RNA-binding domain, RBD
View Download 0.447 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.635 d.58.3 Protease propeptides/inhibitors
View Download 0.569 d.58.4 Dimeric alpha+beta barrel
View Download 0.429 d.57.1 DNA damage-inducible protein DinI
View Download 0.426 d.58.12 eEF-1beta-like
View Download 0.401 d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.384 a.77.1 DEATH domain
View Download 0.369 d.45.1 ClpS-like
View Download 0.368 d.58.17 Metal-binding domain
View Download 0.345 d.58.5 GlnB-like
View Download 0.332 d.51.1 Eukaryotic type KH-domain (KH-domain type I)
View Download 0.327 a.6.1 Putative DNA-binding domain
View Download 0.289 d.19.1 MHC antigen-recognition domain
View Download 0.280 b.40.2 Bacterial enterotoxins
View Download 0.272 d.58.43 Mechanosensitive channel protein MscS (YggB), C-terminal domain
View Download 0.263 d.15.1 Ubiquitin-like
View Download 0.257 d.9.2 Description not found.
View Download 0.249 d.94.1 HPr-like
View Download 0.241 d.101.1 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5
View Download 0.240 d.54.1 Enolase N-terminal domain-like
View Download 0.234 a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.234 d.58.14 Ribosomal protein S6
View Download 0.233 d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.229 a.2.2 Ribosomal protein L29 (L29p)
View Download 0.221 d.58.18 Regulatory domain in the aminoacid metabolism
View Download 0.218 d.58.49 YajQ-like
View Download 0.216 d.82.2 Frataxin-like
View Download 0.205 g.52.1 Inhibitor of apoptosis (IAP) repeat
View Download 0.202 f.16.1 Gated mechanosensitive channel
View Download 0.201 d.56.1 GroEL-intermediate domain like

Predicted Domain #2
Region A:
Residues: [78-409] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDSFPEIKAN IPPSPRSGNV DKSRKRNLID DLKKDVPMSQ PLKEQEVREH QMKKERFDRA  60
   61 LESKLLGKRH ITYANSDISN KELYINEIKS LKHEIKELRK EKNDTLNNYD TLEEETDDLK 120
  121 NRLQALEKEL DAKNKIVNSR KVDDHSGCIE EREQMERKLA ELERKLKTVK DQVLELENNS 180
  181 DVQSLKLRSK EDELKNLMNE LNELKSNAEE KDTQLEFKKN ELRKRTNELN ELKIKSDEMD 240
  241 LQLKQKQNES KRLKDELNEL ETKFSENGSQ SSAKENELKM LKNKIAELEE EISTKNSQLI 300
  301 AKEGKLASLM AQLTQLESKL NQRDSQLGSR EE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 63.68867
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [410-478] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELKKTNDKLQ KDIRIAREET VSKDERIIDL QKKVKQLEND LFVIKKTHSE SKTITDNELE  60
   61 SKDKLIKIL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.39794
Match: 2tmaA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [479-649] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENDLKVAQEK YSKMEKELKE REFNYKISES KLEDEKTTLN EKISNLAAEN SQLKNKIEDN  60
   61 STATHHMKEN YEKQLESLRK DIEEYKESAK DSEDKIEELK IRIAENSAKV SEKRSKDIKQ 120
  121 KDEQISDLTQ NLKLQEDEIS SLKSIIDRYK KDFNQLKSEQ SNIQHDLNLQ I

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 14.1
Match: 1hciA
Description: alpha-actinin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.87991790206998 bayes_pls_golite062009
cytoskeletal protein binding 2.1457670954804 bayes_pls_golite062009
transcription regulator activity 2.122580758085 bayes_pls_golite062009
DNA binding 1.98453325263719 bayes_pls_golite062009
nucleic acid binding 1.93681952439958 bayes_pls_golite062009
actin binding 1.48871115327078 bayes_pls_golite062009
transcription factor activity 1.36872096268289 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.09150919349912 bayes_pls_golite062009
sequence-specific DNA binding 1.03881604759993 bayes_pls_golite062009
protein binding 1.03780839342631 bayes_pls_golite062009
chromatin binding 0.545627011042409 bayes_pls_golite062009
actin filament binding 0.26311995282891 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.18367441245103 bayes_pls_golite062009
transcription activator activity 0.174325083775401 bayes_pls_golite062009
transcription factor binding 0.14097776282047 bayes_pls_golite062009
centromeric DNA binding 0.09491254824772 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [650-847] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LNLENKLIES EDELKSLRDS QKIEIENWKR KYNNLSLEND RLLTEKESAS DKEREISILN  60
   61 RKLDEMDKEK WNLQESKEKY KRELQKVITA NDRLRREKEE LNENSNNIRI MEDKMTRIKK 120
  121 NYLSEITSLQ EENRRLEERL ILNERRKDND STMQLNDIIS YYKLKYHSEV RHNNDLKVIN 180
  181 DYLNKVLALG TRRLRLDT

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 14.1
Match: 1hciA
Description: alpha-actinin
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [848-944] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKGEHSLNIS LPDDDELDRD YYNSHVYTRY HDYEYPLRFN LNRRGPYFER RLSFKTVALL  60
   61 VLACVRMKRI AFYRRSDDNR LRILRDRIES SSGRISW

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.609 0.961 central plaque of spindle pole body a.39.1 EF-hand
View Download 0.626 0.961 central plaque of spindle pole body a.29.2 Bromodomain
View Download 0.566 0.961 central plaque of spindle pole body a.71.2 Helical domain of Sec23/24
View Download 0.535 0.961 central plaque of spindle pole body d.58.20 NAD-binding domain of HMG-CoA reductase
View Download 0.618 0.961 central plaque of spindle pole body a.181.1 Antibiotic binding domain of TipA-like multidrug resistance regulators
View Download 0.529 0.961 central plaque of spindle pole body a.77.1 DEATH domain
View Download 0.511 0.961 central plaque of spindle pole body a.29.2 Bromodomain
View Download 0.505 0.961 central plaque of spindle pole body a.46.1 Methionine synthase domain
View Download 0.473 0.961 central plaque of spindle pole body c.44.2 Enzyme IIB-cellobiose
View Download 0.472 0.961 central plaque of spindle pole body a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.469 0.961 central plaque of spindle pole body a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.460 0.961 central plaque of spindle pole body a.29.4 RecG, N-terminal domain
View Download 0.433 0.961 central plaque of spindle pole body a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.422 0.961 central plaque of spindle pole body f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.415 0.961 central plaque of spindle pole body a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.395 0.961 central plaque of spindle pole body a.90.1 Transcription factor STAT-4 N-domain
View Download 0.391 0.961 central plaque of spindle pole body a.151.1 Glutamyl tRNA-reductase dimerization domain
View Download 0.388 0.961 central plaque of spindle pole body a.74.1 Cyclin-like
View Download 0.384 0.961 central plaque of spindle pole body a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.372 0.961 central plaque of spindle pole body a.1.1 Globin-like
View Download 0.366 0.961 central plaque of spindle pole body a.1.1 Globin-like
View Download 0.365 0.961 central plaque of spindle pole body i.11.1 Computational models partly based on NMR data
View Download 0.364 0.961 central plaque of spindle pole body a.118.1 ARM repeat
View Download 0.357 0.961 central plaque of spindle pole body f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.350 0.961 central plaque of spindle pole body d.51.1 Eukaryotic type KH-domain (KH-domain type I)
View Download 0.350 0.961 central plaque of spindle pole body d.197.1 Protein-L-isoaspartyl O-methyltransferase, C-terminal domain
View Download 0.336 0.961 central plaque of spindle pole body a.133.1 Phospholipase A2, PLA2
View Download 0.332 0.961 central plaque of spindle pole body a.24.17 Group V grass pollen allergen
View Download 0.318 0.961 central plaque of spindle pole body a.3.1 Cytochrome c
View Download 0.315 0.961 central plaque of spindle pole body a.24.4 Hemerythrin
View Download 0.313 0.961 central plaque of spindle pole body a.91.1 Regulator of G-protein signalling, RGS
View Download 0.309 0.961 central plaque of spindle pole body a.64.1 Saposin
View Download 0.308 0.961 central plaque of spindle pole body d.27.1 Ribosomal protein S16
View Download 0.301 0.961 central plaque of spindle pole body b.34.9 Tudor/PWWP/MBT
View Download 0.301 0.961 central plaque of spindle pole body a.64.1 Saposin
View Download 0.300 0.961 central plaque of spindle pole body d.58.26 GHMP Kinase, C-terminal domain
View Download 0.299 0.961 central plaque of spindle pole body a.22.1 Histone-fold
View Download 0.293 0.961 central plaque of spindle pole body a.24.3 Cytochromes
View Download 0.280 0.961 central plaque of spindle pole body a.7.8 GAT domain
View Download 0.279 0.961 central plaque of spindle pole body a.4.5 "Winged helix" DNA-binding domain
View Download 0.269 0.961 central plaque of spindle pole body a.40.1 Calponin-homology domain, CH-domain
View Download 0.260 0.961 central plaque of spindle pole body a.24.3 Cytochromes
View Download 0.253 0.961 central plaque of spindle pole body a.48.1 N-terminal domain of cbl (N-cbl)
View Download 0.251 0.961 central plaque of spindle pole body a.4.5 "Winged helix" DNA-binding domain
View Download 0.248 0.961 central plaque of spindle pole body a.91.1 Regulator of G-protein signalling, RGS
View Download 0.243 0.961 central plaque of spindle pole body d.50.3 PI-Pfui intein middle domain
View Download 0.242 0.961 central plaque of spindle pole body a.126.1 Serum albumin-like
View Download 0.239 0.961 central plaque of spindle pole body a.7.7 BAG domain
View Download 0.238 0.961 central plaque of spindle pole body a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.234 0.961 central plaque of spindle pole body a.24.11 Bacterial GAP domain
View Download 0.230 0.961 central plaque of spindle pole body a.136.1 Repressor of bacterial conjugation FinO
View Download 0.228 0.961 central plaque of spindle pole body a.156.1 S13-like H2TH domain
View Download 0.228 0.961 central plaque of spindle pole body a.1.1 Globin-like
View Download 0.222 0.961 central plaque of spindle pole body g.45.1 Pyk2-associated protein beta ARF-GAP domain
View Download 0.214 0.961 central plaque of spindle pole body a.24.3 Cytochromes
View Download 0.205 0.961 central plaque of spindle pole body a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain

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