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View Structure Prediction Details

Protein: UTP4
Organism: Saccharomyces cerevisiae
Length: 776 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for UTP4.

Description E-value Query
Range
Subject
Range
YY46_NOSS1 - Uncharacterized WD repeat-containing protein alr3466 OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=...
gi|25530855 - pir||AC2239 WD-40 repeat protein [imported] - Nostoc sp. (strain PCC 7120)
0.0 [1..684] [855..1479]
gi|17225210 - gi|17225210|gb|AAL37301.1|AF323585_1 beta transducin-like protein HET-D2Y [Podospora anserina]
0.0 [2..548] [823..1316]

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Predicted Domain #1
Region A:
Residues: [1-73]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSLLSVLK EKSRSLKIRN KPVKMTSQER MIVHRCRFVD FTPATITSLA FSHKSNINKL  60
   61 TPSDLRLAIG RSN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.669 a.4.5 "Winged helix" DNA-binding domain
View Download 0.598 a.39.1 EF-hand
View Download 0.502 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.531 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.456 a.5.6 Hypothetical protein MTH1615
View Download 0.436 a.59.1 PAH2 domain
View Download 0.429 a.4.5 "Winged helix" DNA-binding domain
View Download 0.429 a.65.1 Annexin
View Download 0.384 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.382 a.179.1 Replisome organizer (g39p helicase loader/inhibitor protein)
View Download 0.371 d.16.1 FAD-linked reductases, C-terminal domain
View Download 0.358 a.4.5 "Winged helix" DNA-binding domain
View Download 0.353 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.353 a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.350 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.349 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.345 a.28.1 ACP-like
View Download 0.333 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.330 a.76.1 Iron-dependent represor protein, dimerization domain
View Download 0.326 a.4.1 Homeodomain-like
View Download 0.321 d.29.1 Ribosomal protein L31e
View Download 0.313 a.3.1 Cytochrome c
View Download 0.309 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.308 a.74.1 Cyclin-like
View Download 0.304 c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.299 d.8.1 Urease, gamma-subunit
View Download 0.296 a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.279 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.276 a.64.1 Saposin
View Download 0.275 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.271 a.77.1 DEATH domain
View Download 0.253 a.77.1 DEATH domain
View Download 0.234 a.39.1 EF-hand
View Download 0.230 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.215 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.214 a.24.4 Hemerythrin
View Download 0.214 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.208 a.77.1 DEATH domain

Predicted functions:

Term Confidence Notes
snoRNA binding 6.03079504484743 bayes_pls_golite062009
3.41022148055944 bayes_pls_golite062009
RNA binding 3.0829625416797 bayes_pls_golite062009
binding 2.42570478946173 bayes_pls_golite062009
transcription regulator activity 2.3610959773142 bayes_pls_golite062009
nucleic acid binding 2.30918780727915 bayes_pls_golite062009
protein binding 2.26925404328312 bayes_pls_golite062009
DNA binding 1.71685536470455 bayes_pls_golite062009
cytoskeletal protein binding 1.5283366007575 bayes_pls_golite062009
structural molecule activity 1.31060431370834 bayes_pls_golite062009
transcription activator activity 1.23969853550045 bayes_pls_golite062009
transcription factor activity 1.08768505897883 bayes_pls_golite062009
actin binding 0.794986868016276 bayes_pls_golite062009
transcription repressor activity 0.658573452658359 bayes_pls_golite062009
transcription factor binding 0.489473003915035 bayes_pls_golite062009
transcription cofactor activity 0.30761651528651 bayes_pls_golite062009
ligase activity 0.280267687917718 bayes_pls_golite062009
tubulin binding 0.194781260474147 bayes_pls_golite062009
transcription corepressor activity 0.182612389752591 bayes_pls_golite062009
microtubule binding 0.167936232702449 bayes_pls_golite062009
mRNA binding 0.0519838181830878 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [74-166]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNIEIWNPRN NWFQEMVIEG GKDRSIEGLC WSNVNGESLR LFSIGGSTVV TEWDLATGLP  60
   61 LRNYDCNSGV IWSISINDSQ DKLSVGCDNG TVV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 79.30103
Match: 1gg2B_
Description: beta1-subunit of the signal-transducing G protein heterotrimer
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [167-504]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LIDISGGPGV LEHDTILMRQ EARVLTLAWK KDDFVIGGCS DGRIRIWSAQ KNDENMGRLL  60
   61 HTMKVDKAKK ESTLVWSVIY LPRTDQIASG DSTGSIKFWD FQFATLNQSF KAHDADVLCL 120
  121 TTDTDNNYVF SAGVDRKIFQ FSQNTNKSQK NNRWVNSSNR LLHGNDIRAI CAYQSKGADF 180
  181 LVSGGVEKTL VINSLTSFSN GNYRKMPTVE PYSKNVLVNK EQRLVVSWSE STVKIWTMGT 240
  241 DSSTEQNYKL VCKLTLKDDQ NISTCSLSPD GQVLVVGRPS TTKVFHLQPV GNKLKVTKLD 300
  301 NDLLLRTSTK LVKFIDNSKI VICSCEDDVF IVDLESEE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 96.24799
Match: 1erjA_
Description: Tup1, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [505-692]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DEKPQEVELL EVTSTKSSIK VPYINRINHL EVDQNIAVIS RGCGVVDILD LKARISKPLA  60
   61 RLNNFITAVH INTSRKSVVV ITADNKIYEF NMNLNSEAEN EDSESVLTQW SKNNTDNLPK 120
  121 EWKTLKENCV GIFSDIENSS RLWFWGATWI SRIDFDVDFP INKRRKQKKR THEGLTITDE 180
  181 SNFMNDEE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [693-776]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDEDDDIDME ISENLNVLLN QGNKIKSTDV QRNEESSGHF FFTDKYKPLL FVDLISSNEL  60
   61 AIIERNPLTF HSKQKAFIQP KLVF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.528 d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.400 b.101.1 Ribonuclease domain of colicin E3
View Download 0.463 d.105.1 Clathrin adaptor appendage, alpha and beta chain-specific domain
View Download 0.458 d.17.2 Copper amine oxidase, domains 1 and 2
View Download 0.360 d.129.1 TATA-box binding protein-like
View Download 0.346 d.9.1 Interleukin 8-like chemokines
View Download 0.281 d.17.2 Copper amine oxidase, domains 1 and 2
View Download 0.258 d.169.1 C-type lectin-like
View Download 0.242 b.55.1 PH domain-like
View Download 0.229 b.55.1 PH domain-like
View Download 0.222 g.41.3 Zinc beta-ribbon
View Download 0.222 b.11.1 gamma-Crystallin-like
View Download 0.203 d.17.1 Cystatin/monellin


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle