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View Structure Prediction Details

Protein: DPL1
Organism: Saccharomyces cerevisiae
Length: 589 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DPL1.

Description E-value Query
Range		 Subject
Range
SGPL_YEAST - Sphingosine-1-phosphate lyase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DPL1 PE=1 ...
DPL1 - Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base p...
 0.0 [1..589] [1..589]
gi|3417234 - gi|3417234|gb|AAC31639.1| dopa decarboxylase [Aedes aegypti]
 0.0 [86..541] [6..482]
gi|112984466, gi... - gi|13899133|gb|AAK48988.1|AF372836_1 dopa decarboxylase [Bombyx mori], gi|112984466|ref|NP_001037174...
 0.0 [94..540] [4..471]
gi|15824041 - gi|15824041|dbj|BAB68549.1| dopa decarboxylase [Mythimna separata]
 0.0 [96..541] [6..472]
Ddc-PC - The gene Dopa decarboxylase is referred to in FlyBase by the symbol Dmel\Ddc (CG10697, FBgn0000422)....
 0.0 [94..542] [39..507]
gi|7768790 - gi|7768790|dbj|BAA95568.1| dopa decarboxylase [Tenebrio molitor]
 0.0 [95..541] [5..472]
gi|15799267 - gi|15799267|dbj|BAB68545.1| dopa decarboxylase [Mamestra brassicae]
 0.0 [96..541] [6..472]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [94..542] [39..507]

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Predicted Domain #1
Region A:
Residues: [1-79] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGVSNKTVS INGWYGMPIH LLREEGDFAQ FMILTINELK IAIHGYLRNT PWYNMLKDYL  60
   61 FVIFCYKLIS NFFYLLKVY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 SCOP
Match		 SCOP Description
View Download 0.685 a.3.1 Cytochrome c
View Download 0.688 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.727 a.90.1 Transcription factor STAT-4 N-domain
View Download 0.645 c.47.2 RNA 3'-terminal phosphate cyclase, RPTC, insert domain
View Download 0.744 d.50.2 Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain
View Download 0.744 d.50.2 Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain
View Download 0.727 a.90.1 Transcription factor STAT-4 N-domain
View Download 0.690 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.688 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.685 a.3.1 Cytochrome c
View Download 0.627 a.51.1 Cytochrome c oxidase subunit h
View Download 0.590 a.47.2 t-snare proteins
View Download 0.565 a.24.17 Group V grass pollen allergen
View Download 0.561 b.61.3 D-aminopeptidase, middle and C-terminal domains
View Download 0.560 a.46.1 Methionine synthase domain
View Download 0.554 a.2.3 Chaperone J-domain
View Download 0.548 a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.535 a.2.2 Ribosomal protein L29 (L29p)
View Download 0.535 d.50.1 dsRNA-binding domain-like
View Download 0.512 a.50.1 Anaphylotoxins (complement system)
View Download 0.511 d.52.5 Probable GTPase Der, C-terminal domain
View Download 0.496 d.50.1 dsRNA-binding domain-like
View Download 0.479 a.29.2 Bromodomain
View Download 0.459 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.457 d.87.2 CO dehydrogenase flavoprotein C-terminal domain-like
View Download 0.452 a.2.3 Chaperone J-domain
View Download 0.449 a.64.1 Saposin
View Download 0.434 d.54.1 Enolase N-terminal domain-like
View Download 0.392 a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.382 a.159.2 FF domain
View Download 0.379 a.61.1 Retroviral matrix proteins
View Download 0.379 d.129.2 Phosphoglucomutase, C-terminal domain
View Download 0.375 a.74.1 Cyclin-like
View Download 0.374 a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.371 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.371 f.13.1 Family A G protein-coupled receptor-like
View Download 0.370 b.71.1 Glycosyl hydrolase domain
View Download 0.370 a.4.5 "Winged helix" DNA-binding domain
View Download 0.367 i.1.1 Ribosome and ribosomal fragments
View Download 0.365 b.43.4 Riboflavin synthase domain-like
View Download 0.358 b.71.1 Glycosyl hydrolase domain
View Download 0.345 a.4.12 TrpR-like
View Download 0.333 g.7.1 Snake toxin-like
View Download 0.333 a.2.7 tRNA-binding arm
View Download 0.330 a.71.2 Helical domain of Sec23/24
View Download 0.327 a.16.1 S15/NS1 RNA-binding domain
View Download 0.325 a.72.1 Functional domain of the splicing factor Prp18
View Download 0.321 g.18.1 Complement control module/SCR domain
View Download 0.317 d.129.1 TATA-box binding protein-like
View Download 0.314 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.314 a.4.5 "Winged helix" DNA-binding domain
View Download 0.308 a.30.1 ROP protein
View Download 0.305 a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.305 a.3.1 Cytochrome c
View Download 0.300 c.55.4 Translational machinery components
View Download 0.300 d.105.1 Clathrin adaptor appendage, alpha and beta chain-specific domain
View Download 0.295 d.58.12 eEF-1beta-like
View Download 0.289 a.64.1 Saposin
View Download 0.287 d.58.17 Metal-binding domain
View Download 0.286 a.108.1 Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View Download 0.280 a.7.1 Spectrin repeat
View Download 0.277 a.7.6 Ribosomal protein S20
View Download 0.274 d.214.1 Hypothetical protein MTH1880
View Download 0.269 b.1.1 Immunoglobulin
View Download 0.265 d.10.1 DNA-binding domain
View Download 0.265 a.85.1 Hemocyanin, N-terminal domain
View Download 0.262 a.156.1 S13-like H2TH domain
View Download 0.260 b.40.6 MOP-like
View Download 0.259 a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.259 a.4.1 Homeodomain-like
View Download 0.258 d.15.1 Ubiquitin-like
View Download 0.256 d.10.1 DNA-binding domain
View Download 0.255 b.13.3 Description not found.
View Download 0.255 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.252 a.24.4 Hemerythrin
View Download 0.251 a.16.1 S15/NS1 RNA-binding domain
View Download 0.249 d.101.1 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5
View Download 0.247 b.15.1 HSP20-like chaperones
View Download 0.246 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.243 a.4.5 "Winged helix" DNA-binding domain
View Download 0.243 b.36.1 PDZ domain-like
View Download 0.243 a.60.5 Barrier-to-autointegration factor, BAF
View Download 0.240 a.118.1 ARM repeat
View Download 0.240 a.105.1 FIS-like
View Download 0.236 a.47.2 t-snare proteins
View Download 0.234 a.29.4 RecG, N-terminal domain
View Download 0.233 a.118.1 ARM repeat
View Download 0.229 b.40.2 Bacterial enterotoxins
View Download 0.225 d.204.1 Ribosome binding protein Y (YfiA homologue)
View Download 0.223 a.130.1 Chorismate mutase II
View Download 0.221 a.24.17 Group V grass pollen allergen
View Download 0.216 b.1.2 Fibronectin type III
View Download 0.215 d.109.1 Actin depolymerizing proteins
View Download 0.202 d.233.1 Inhibitor of vertebrate lysozyme, Ivy
View Download 0.201 a.2.9 C-terminal UvrC-binding domain of UvrB

Predicted Domain #2
Region A:
Residues: [80-162] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GPVRLAVRTY EHSSRRLFRW LLDSPFLRGT VEKEVTKVKQ SIEDELIRSD SQLMNFPQLP  60
   61 SNGIPQDDVI EELNKLNDLI PHT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 107.0
Match: 1js3A_
Description: DOPA decarboxylase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
serine C-palmitoyltransferase activity 4.27273846204139 bayes_pls_golite062009
C-palmitoyltransferase activity 4.27273846204139 bayes_pls_golite062009
catalytic activity 2.29878871754893 bayes_pls_golite062009
transferase activity, transferring nitrogenous groups 1.18577404365776 bayes_pls_golite062009
transaminase activity 1.15255422926249 bayes_pls_golite062009
transferase activity 0.737426388870721 bayes_pls_golite062009
transcription regulator activity 0.691073358419788 bayes_pls_golite062009
binding 0.661198018681765 bayes_pls_golite062009
DNA binding 0.579562080072574 bayes_pls_golite062009
nucleic acid binding 0.547593348248892 bayes_pls_golite062009
C-acyltransferase activity 0.46392133442786 bayes_pls_golite062009
transcription factor activity 0.352624414131738 bayes_pls_golite062009
4-aminobutyrate transaminase activity 0.122706514261728 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [163-589] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QWKEGKVSGA VYHGGDDLIH LQTIAYEKYC VANQLHPDVF PAVRKMESEV VSMVLRMFNA  60
   61 PSDTGCGTTT SGGTESLLLA CLSAKMYALH HRGITEPEII APVTAHAGFD KAAYYFGMKL 120
  121 RHVELDPTTY QVDLGKVKKF INKNTILLVG SAPNFPHGIA DDIEGLGKIA QKYKLPLHVD 180
  181 SCLGSFIVSF MEKAGYKNLP LLDFRVPGVT SISCDTHKYG FAPKGSSVIM YRNSDLRMHQ 240
  241 YYVNPAWTGG LYGSPTLAGS RPGAIVVGCW ATMVNMGENG YIESCQEIVG AAMKFKKYIQ 300
  301 ENIPDLNIMG NPRYSVISFS SKTLNIHELS DRLSKKGWHF NALQKPVALH MAFTRLSAHV 360
  361 VDEICDILRT TVQELKSESN SKPSPDGTSA LYGVAGSVKT AGVADKLIVG FLDALYKLGP 420
  421 GEDTATK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 107.0
Match: 1js3A_
Description: DOPA decarboxylase
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle