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View Structure Prediction Details

Protein: DPL1
Organism: Saccharomyces cerevisiae
Length: 589 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DPL1.

Description E-value Query
Range
Subject
Range
SGPL_YEAST - Sphingosine-1-phosphate lyase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DPL1 PE=1 ...
DPL1 - Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base p...
0.0 [1..589] [1..589]
gi|3417234 - gi|3417234|gb|AAC31639.1| dopa decarboxylase [Aedes aegypti]
0.0 [86..541] [6..482]
gi|112984466, gi... - gi|13899133|gb|AAK48988.1|AF372836_1 dopa decarboxylase [Bombyx mori], gi|112984466|ref|NP_001037174...
0.0 [94..540] [4..471]
gi|15824041 - gi|15824041|dbj|BAB68549.1| dopa decarboxylase [Mythimna separata]
0.0 [96..541] [6..472]
Ddc-PC - The gene Dopa decarboxylase is referred to in FlyBase by the symbol Dmel\Ddc (CG10697, FBgn0000422)....
0.0 [94..542] [39..507]
gi|7768790 - gi|7768790|dbj|BAA95568.1| dopa decarboxylase [Tenebrio molitor]
0.0 [95..541] [5..472]
gi|15799267 - gi|15799267|dbj|BAB68545.1| dopa decarboxylase [Mamestra brassicae]
0.0 [96..541] [6..472]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [94..542] [39..507]

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Predicted Domain #1
Region A:
Residues: [1-79]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGVSNKTVS INGWYGMPIH LLREEGDFAQ FMILTINELK IAIHGYLRNT PWYNMLKDYL  60
   61 FVIFCYKLIS NFFYLLKVY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [80-162]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GPVRLAVRTY EHSSRRLFRW LLDSPFLRGT VEKEVTKVKQ SIEDELIRSD SQLMNFPQLP  60
   61 SNGIPQDDVI EELNKLNDLI PHT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 107.0
Match: 1js3A_
Description: DOPA decarboxylase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
serine C-palmitoyltransferase activity 4.27273846204139 bayes_pls_golite062009
C-palmitoyltransferase activity 4.27273846204139 bayes_pls_golite062009
catalytic activity 2.29878871754893 bayes_pls_golite062009
transferase activity, transferring nitrogenous groups 1.18577404365776 bayes_pls_golite062009
transaminase activity 1.15255422926249 bayes_pls_golite062009
transferase activity 0.737426388870721 bayes_pls_golite062009
transcription regulator activity 0.691073358419788 bayes_pls_golite062009
binding 0.661198018681765 bayes_pls_golite062009
DNA binding 0.579562080072574 bayes_pls_golite062009
nucleic acid binding 0.547593348248892 bayes_pls_golite062009
C-acyltransferase activity 0.46392133442786 bayes_pls_golite062009
transcription factor activity 0.352624414131738 bayes_pls_golite062009
4-aminobutyrate transaminase activity 0.122706514261728 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [163-589]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QWKEGKVSGA VYHGGDDLIH LQTIAYEKYC VANQLHPDVF PAVRKMESEV VSMVLRMFNA  60
   61 PSDTGCGTTT SGGTESLLLA CLSAKMYALH HRGITEPEII APVTAHAGFD KAAYYFGMKL 120
  121 RHVELDPTTY QVDLGKVKKF INKNTILLVG SAPNFPHGIA DDIEGLGKIA QKYKLPLHVD 180
  181 SCLGSFIVSF MEKAGYKNLP LLDFRVPGVT SISCDTHKYG FAPKGSSVIM YRNSDLRMHQ 240
  241 YYVNPAWTGG LYGSPTLAGS RPGAIVVGCW ATMVNMGENG YIESCQEIVG AAMKFKKYIQ 300
  301 ENIPDLNIMG NPRYSVISFS SKTLNIHELS DRLSKKGWHF NALQKPVALH MAFTRLSAHV 360
  361 VDEICDILRT TVQELKSESN SKPSPDGTSA LYGVAGSVKT AGVADKLIVG FLDALYKLGP 420
  421 GEDTATK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 107.0
Match: 1js3A_
Description: DOPA decarboxylase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle