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View Structure Prediction Details

Protein: CCC2
Organism: Saccharomyces cerevisiae
Length: 1004 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CCC2.

Description E-value Query
Range		 Subject
Range
CCC2 - Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytos...
ATU2_YEAST - Copper-transporting ATPase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CCC2 PE=1 SV=...
 0.0 [1..1004] [1..1004]
ATP7A - ATPase, Cu++ transporting, alpha polypeptide
 0.0 [2..983] [377..1449]
gi|6006293, gi|6... - gi|6006306|dbj|BAA84777.1| ATPase 7B [Rattus norvegicus], gi|6006304|dbj|BAA84776.1| ATPase 7B [Ratt...
 0.0 [2..989] [354..1408]
AT7B_MOUSE, ATP7... - Copper-transporting ATPase 2 OS=Mus musculus GN=Atp7b PE=1 SV=1, (Q64446) Copper-transporting ATPase...
 0.0 [2..989] [361..1418]
ATP7B_SHEEP - Copper-transporting ATPase 2 OS=Ovis aries GN=ATP7B PE=2 SV=1
 0.0 [3..989] [401..1461]

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Predicted Domain #1
Region A:
Residues: [1-75] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MREVILAVHG MTCSACTNTI NTQLRALKGV TKCDISLVTN ECQVTYDNEV TADSIKEIIE  60
   61 DCGFDCEILR DSEIT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 350.68867
Match: 1fvqA_
Description: Copper transporter domain ccc2a
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
copper chaperone activity 9.82063669832995 bayes_pls_golite062009
copper-dependent protein binding 9.4886676850819 bayes_pls_golite062009
metallochaperone activity 8.74818422646376 bayes_pls_golite062009
copper ion transmembrane transporter activity 8.43432598400875 bayes_pls_golite062009
copper-exporting ATPase activity 8.28760545731379 bayes_pls_golite062009
copper-transporting ATPase activity 8.16711362928142 bayes_pls_golite062009
superoxide dismutase copper chaperone activity 7.67724993505658 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 7.20908701283122 bayes_pls_golite062009
copper ion binding 5.41725082570189 bayes_pls_golite062009
metal ion transmembrane transporter activity 5.4007166857771 bayes_pls_golite062009
cation transmembrane transporter activity 4.61622753861072 bayes_pls_golite062009
ion transmembrane transporter activity 4.52484959112186 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 4.12792340516867 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 4.10264569844449 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 3.70964017127302 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism 3.27250923701445 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 2.98847682261773 bayes_pls_golite062009
metal ion binding 2.69806984896689 bayes_pls_golite062009
cation binding 2.69806984896689 bayes_pls_golite062009
ion binding 2.69078950610234 bayes_pls_golite062009
transition metal ion binding 2.52520930681159 bayes_pls_golite062009
transporter activity 2.43435890488191 bayes_pls_golite062009
transmembrane transporter activity 2.32163502360862 bayes_pls_golite062009
binding 2.31155280022787 bayes_pls_golite062009
substrate-specific transporter activity 2.28845421748925 bayes_pls_golite062009
primary active transmembrane transporter activity 1.62116507842838 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 1.61680623728503 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 1.59572740343301 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 1.5925429451548 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 1.59219836319916 bayes_pls_golite062009
active transmembrane transporter activity 1.53883152283038 bayes_pls_golite062009
hydrolase activity 1.26149508477113 bayes_pls_golite062009
ATPase activity 1.12732384636594 bayes_pls_golite062009
nucleoside-triphosphatase activity 1.1123150216263 bayes_pls_golite062009
pyrophosphatase activity 1.04872000948037 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 1.03270166246194 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1.02977205960797 bayes_pls_golite062009
ATPase activity, coupled 1.02520458852568 bayes_pls_golite062009
protein binding 0.889287086236279 bayes_pls_golite062009
cation-transporting ATPase activity 0.75722873989123 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [76-163] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AISTKEGLLS VQGMTCGSCV STVTKQVEGI EGVESVVVSL VTEECHVIYE PSKTTLETAR  60
   61 EMIEDCGFDS NIIMDGNGNA DMTEKTVI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 56.0
Match: 1kqkA_
Description: Potential copper-translocating P-type ATPase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
copper chaperone activity 9.82063669832995 bayes_pls_golite062009
copper-dependent protein binding 9.4886676850819 bayes_pls_golite062009
metallochaperone activity 8.74818422646376 bayes_pls_golite062009
copper ion transmembrane transporter activity 8.43432598400875 bayes_pls_golite062009
copper-exporting ATPase activity 8.28760545731379 bayes_pls_golite062009
copper-transporting ATPase activity 8.16711362928142 bayes_pls_golite062009
superoxide dismutase copper chaperone activity 7.67724993505658 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 7.20908701283122 bayes_pls_golite062009
copper ion binding 5.41725082570189 bayes_pls_golite062009
metal ion transmembrane transporter activity 5.4007166857771 bayes_pls_golite062009
cation transmembrane transporter activity 4.61622753861072 bayes_pls_golite062009
ion transmembrane transporter activity 4.52484959112186 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 4.12792340516867 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 4.10264569844449 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 3.70964017127302 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism 3.27250923701445 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 2.98847682261773 bayes_pls_golite062009
metal ion binding 2.69806984896689 bayes_pls_golite062009
cation binding 2.69806984896689 bayes_pls_golite062009
ion binding 2.69078950610234 bayes_pls_golite062009
transition metal ion binding 2.52520930681159 bayes_pls_golite062009
transporter activity 2.43435890488191 bayes_pls_golite062009
transmembrane transporter activity 2.32163502360862 bayes_pls_golite062009
binding 2.31155280022787 bayes_pls_golite062009
substrate-specific transporter activity 2.28845421748925 bayes_pls_golite062009
primary active transmembrane transporter activity 1.62116507842838 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 1.61680623728503 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 1.59572740343301 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 1.5925429451548 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 1.59219836319916 bayes_pls_golite062009
active transmembrane transporter activity 1.53883152283038 bayes_pls_golite062009
hydrolase activity 1.26149508477113 bayes_pls_golite062009
ATPase activity 1.12732384636594 bayes_pls_golite062009
nucleoside-triphosphatase activity 1.1123150216263 bayes_pls_golite062009
pyrophosphatase activity 1.04872000948037 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 1.03270166246194 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1.02977205960797 bayes_pls_golite062009
ATPase activity, coupled 1.02520458852568 bayes_pls_golite062009
protein binding 0.889287086236279 bayes_pls_golite062009
cation-transporting ATPase activity 0.75722873989123 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [164-282] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKVTKAFEDE SPLILSSVSE RFQFLLDLGV KSIEISDDMH TLTIKYCCNE LGIRDLLRHL  60
   61 ERTGYKFTVF SNLDNTTQLR LLSKEDEIRF WKKNSIKSTL LAIICMLLYM IVPMMWPTI

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 11.46
Match: 1k0vA
Description: Copper chaperone
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [283-335] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VQDRIFPYKE TSFVRGLFYR DILGVILASY IQFSVGFYFY KAAWASLKHG SGT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 SCOP
Match		 SCOP Description
View Download 0.630 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.473 a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.529 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.488 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.461 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.436 a.74.1 Cyclin-like
View Download 0.430 a.5.2 UBA-like
View Download 0.419 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.397 a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.395 a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.379 a.32.1 Transcription factor IIA (TFIIA), alpha-helical domain
View Download 0.372 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.360 a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.347 a.74.1 Cyclin-like
View Download 0.347 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.330 a.4.5 "Winged helix" DNA-binding domain
View Download 0.318 a.108.1 Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View Download 0.306 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.300 a.9.1 Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
View Download 0.293 a.140.3 Rho termination factor, N-terminal domain
View Download 0.291 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.287 d.58.17 Metal-binding domain
View Download 0.269 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.264 f.13.1 Family A G protein-coupled receptor-like
View Download 0.262 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.261 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.258 d.58.17 Metal-binding domain
View Download 0.253 a.3.1 Cytochrome c
View Download 0.249 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.246 a.144.1 PABC (PABP) domain
View Download 0.244 a.140.1 LEM domain
View Download 0.242 a.77.1 DEATH domain
View Download 0.241 a.5.2 UBA-like
View Download 0.239 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.236 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.225 a.144.1 PABC (PABP) domain
View Download 0.224 a.5.7 4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View Download 0.216 a.9.1 Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
View Download 0.214 a.38.1 Helix-loop-helix DNA-binding domain
View Download 0.213 a.32.1 Transcription factor IIA (TFIIA), alpha-helical domain
View Download 0.206 a.144.2 Ribosomal protein L20
View Download 0.201 a.32.1 Transcription factor IIA (TFIIA), alpha-helical domain

Predicted Domain #5
Region A:
Residues: [336-409] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTLVCVSTT CAYTFSVFSL VHNMFHPSST GKLPRIVFDT SIMIISYISI GKYLETLAKS  60
   61 QTSTALSKLI QLTP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [554-1004] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPPVAFTANT KADNFFICLQ TATSVVIVAC PCALGLATPT AIMVGTGVGA QNGVLIKGGE  60
   61 VLEKFNSITT FVFDKTGTLT TGFMVVKKFL KDSNWVGNVD EDEVLACIKA TESISDHPVS 120
  121 KAIIRYCDGL NCNKALNAVV LESEYVLGKG IVSKCQVNGN TYDICIGNEA LILEDALKKS 180
  181 GFINSNVDQG NTVSYVSVNG HVFGLFEIND EVKHDSYATV QYLQRNGYET YMITGDNNSA 240
  241 AKRVAREVGI SFENVYSDVS PTGKCDLVKK IQDKEGNNKV AVVGDGINDA PALALSDLGI 300
  301 AISTGTEIAI EAADIVILCG NDLNTNSLRG LANAIDISLK TFKRIKLNLF WALCYNIFMI 360
  361 PIAMGVLIPW GITLPPMLAG LAMAFSSVSV VLSSLMLKKW TPPDIESHGI SDFKSKFSIG 420
  421 NFWSRLFSTR AIAGEQDIES QAGLMSNEEV L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 221.9897
Match: 1eulA_
Description: Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M

Predicted Domain #6
Region A:
Residues: [410-553] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVCSIISDVE RNETKEIPIE LLQVNDIVEI KPGMKIPADG IITRGESEID ESLMTGESIL  60
   61 VPKKTGFPVI AGSVNGPGHF YFRTTTVGEE TKLANIIKVM KEAQLSKAPI QGYADYLASI 120
  121 FVPGILILAV LTFFIWCFIL NISA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 221.9897
Match: 1eulA_
Description: Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle