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View Structure Prediction Details

Protein: SCC2
Organism: Saccharomyces cerevisiae
Length: 1493 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SCC2.

Description E-value Query
Range
Subject
Range
SCC2_YEAST - Sister chromatid cohesion protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SCC2...
SCC2 - Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for loading of cohesin complexes...
0.0 [1..1493] [1..1493]
mis4 - cohesin loading factor Mis4
MIS4_SCHPO - Sister chromatid cohesion protein mis4 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=mis...
0.0 [277..1385] [319..1476]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [243..1382] [649..1912]
gi|11358123, gi|... - gi|9755809|emb|CAC01753.1| putative protein [Arabidopsis thaliana], gi|15242325|ref|NP_197058.1| bin...
6.0E-99 [423..1406] [452..1499]

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Predicted Domain #1
Region A:
Residues: [1-354]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYPGKDKNI PGRIIEALED LPLSYLVPKD GLAALVNAPM RVSLPFDKTI FTSADDGRDV  60
   61 NINVLGTANS TTSSIKNEAE KERLVFKRPS NFTSSANSVD YVPTNFLEGL SPLAQSVLST 120
  121 HKGLNDSINI EKKSEIVSRP EAKHKLESVT SNAGNLSFND NSSNKKTKTS TGVTMTQANL 180
  181 AEQYLNDLKN ILDIVGFDQN SAEIGNIEYW LQLPNKKFVL TTNCLTKLQM TIKNITDNPQ 240
  241 LSNSIEITWL LRLLDVMVCN IKFSKSSLKM GLDDSMLRYI ALLSTIVLFN IFLLGKNDSN 300
  301 LHRESYIMEP VNFLSDLIES LKILTIEYGS LKIEFDTFQE ALELLPKYIR NGPF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [355-1408]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDDNVTAKLV YIFSDLLMNN DIEATTNIQF QSFWDNVKRI SSDILVSLFG SFDQQRGFII  60
   61 EELLSHIEKL PTKRIQKKLR KVGNQNIYIT DFTFTLMSML ENINCYSFCN QMKDIAPENI 120
  121 DLLKNEYKKQ EEFLFNIVEH INDTILERFF KNPSALRYVI DNFVQDLLLL ISSPQWPVTE 180
  181 KILSSLLKRL LSVYSPSMQV SANIETICLQ LIGNIGSTIF DIKCSTRDHE DNNLIKMINY 240
  241 PETLPHFFKS FEECIAYNET IKCRRSATRF LWNLRLGTIL ILEEYTKDAK EQIITVDNEL 300
  301 KKILEQIKDG GLGPELENRE ADFSTIKLDY FSILHAFELL NLYDPYLKLI LSLLAKDKIK 360
  361 LRSTAIKCLS MLASKDKVIL SNPMVKETIH RRLNDSSASV KDAILDLVSI NSSYFEFYQQ 420
  421 INNNYNDDSI MVRKHVLRIN EKMYDETNDI VTKVYVIARI LMKIEDEEDN IIDMARLILL 480
  481 NRWILKVHEV LDQPEKLKEI SSSVLLVMSR VAIMNEKCSQ LFDLFLNFYL LNKEAHSKEA 540
  541 YDKITHVLTI LTDFLVQKIV ELNSDDTNEK NSIVDKQNFL NLLAKFADST VSFLTKDHIT 600
  601 ALYPYMVSDE KSDFHYYILQ VFRCTFEKLA NFKQKFLYDL ETTLLSRLPK MNVREIDEAM 660
  661 PLIWSVATHR HDTARVAKAC SSCLSHLHPY INKANNEEAA IVVDGKLQRL IYLSTGFARF 720
  721 CFPKPSNDKI AFLQEGETLY EHITKCLLVL SKDKITHVIR RVAVKNLTKL CGNHPKLFNS 780
  781 RHVLHLLDKE FQSDQLDIKL VILESLYDLF LLEERKSVRN TGVNSTLSSN SILKKKLLKT 840
  841 NRVEFANDGV CSALATRFLD NILQLCLLRD LKNSLVAIRL LKLILKFGYT NPSHSIPTVI 900
  901 ALFASTSQYI RHVAYELLED LFEKYETLVF SSLSRGVTKA IHYSIHTDEK YYYKHDHFLS 960
  961 LLEKLCGTGK KNGPKFFKVL KRIMQSYLDD ITDLTSTNSS VQKSIFVLCT NISNITFVSQ1020
 1021 YDLVSLLKTI DLTTDRLKEV IMDEIGDNVS SLSV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [1409-1493]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SEEKLSGIIL IQLSLQDLGT YLLHLYGLRD DVLLLDIVEE SELKNKQLPA KKPDISKFSA  60
   61 QLENIEQYSS NGKLLTYFRK HVKDT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.632 a.39.1 EF-hand
View Download 0.688 a.1.1 Globin-like
View Download 0.750 f.14.1 Voltage-gated potassium channels
View Download 0.713 d.45.1 ClpS-like
View Download 0.578 a.76.1 Iron-dependent represor protein, dimerization domain
View Download 0.518 a.64.1 Saposin
View Download 0.503 a.4.5 "Winged helix" DNA-binding domain
View Download 0.499 a.28.1 ACP-like
View Download 0.485 d.58.49 YajQ-like
View Download 0.426 d.52.4 YhbC-like, N-terminal domain
View Download 0.410 b.9.1 Neurophysin II
View Download 0.408 a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.408 d.58.17 Metal-binding domain
View Download 0.405 a.29.2 Bromodomain
View Download 0.399 a.24.17 Group V grass pollen allergen
View Download 0.396 d.50.3 PI-Pfui intein middle domain
View Download 0.396 a.4.1 Homeodomain-like
View Download 0.395 d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.393 a.156.1 S13-like H2TH domain
View Download 0.390 a.77.1 DEATH domain
View Download 0.381 d.67.2 Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain
View Download 0.380 a.3.1 Cytochrome c
View Download 0.372 a.130.1 Chorismate mutase II
View Download 0.369 a.60.13 Putative methyltransferase TM0872, insert domain
View Download 0.369 a.179.1 Replisome organizer (g39p helicase loader/inhibitor protein)
View Download 0.364 a.69.2 Ypt/Rab-GAP domain of gyp1p
View Download 0.360 a.39.1 EF-hand
View Download 0.335 a.7.6 Ribosomal protein S20
View Download 0.333 a.4.5 "Winged helix" DNA-binding domain
View Download 0.333 a.61.1 Retroviral matrix proteins
View Download 0.330 a.151.1 Glutamyl tRNA-reductase dimerization domain
View Download 0.322 a.76.1 Iron-dependent represor protein, dimerization domain
View Download 0.317 d.237.1 Hypothetical protein YjiA, C-terminal domain
View Download 0.313 d.58.3 Protease propeptides/inhibitors
View Download 0.312 c.15.1 BRCT domain
View Download 0.311 a.16.1 S15/NS1 RNA-binding domain
View Download 0.303 a.29.2 Bromodomain
View Download 0.294 a.118.1 ARM repeat
View Download 0.294 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.289 a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.289 a.118.1 ARM repeat
View Download 0.272 c.47.1 Thioredoxin-like
View Download 0.271 c.24.1 Methylglyoxal synthase-like
View Download 0.271 d.150.1 4'-phosphopantetheinyl transferase
View Download 0.270 a.4.1 Homeodomain-like
View Download 0.255 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.254 d.80.1 Tautomerase/MIF
View Download 0.249 a.4.5 "Winged helix" DNA-binding domain
View Download 0.244 d.203.1 DsrC, the gamma subunit of dissimilatory sulfite reductase
View Download 0.243 d.51.1 Eukaryotic type KH-domain (KH-domain type I)
View Download 0.237 a.3.1 Cytochrome c
View Download 0.231 d.58.5 GlnB-like
View Download 0.228 a.78.1 Fatty acid responsive transcription factor FadR, C-terminal domain
View Download 0.226 d.58.43 Mechanosensitive channel protein MscS (YggB), C-terminal domain
View Download 0.223 d.58.4 Dimeric alpha+beta barrel
View Download 0.220 a.68.1 Wiscott-Aldrich syndrome protein, WASP, C-terminal domain
View Download 0.218 a.4.1 Homeodomain-like
View Download 0.217 a.21.1 HMG-box
View Download 0.213 a.37.1 A DNA-binding domain in eukaryotic transcription factors
View Download 0.210 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.210 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.209 a.7.8 GAT domain
View Download 0.208 a.29.2 Bromodomain

Predicted Domain #4
Region A:
Residues: [381-480]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NIQFQSFWDN VKRISSDILV SLFGSFDQQR GFIIEELLSH IEKLPTKRIQ KKLRKVGNQN  60
   61 IYITDFTFTL MSMLENINCY SFCNQMKDIA PENIDLLKNE 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [481-1309]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YKKQEEFLFN IVEHINDTIL ERFFKNPSAL RYVIDNFVQD LLLLISSPQW PVTEKILSSL  60
   61 LKRLLSVYSP SMQVSANIET ICLQLIGNIG STIFDIKCST RDHEDNNLIK MINYPETLPH 120
  121 FFKSFEECIA YNETIKCRRS ATRFLWNLRL GTILILEEYT KDAKEQIITV DNELKKILEQ 180
  181 IKDGGLGPEL ENREADFSTI KLDYFSILHA FELLNLYDPY LKLILSLLAK DKIKLRSTAI 240
  241 KCLSMLASKD KVILSNPMVK ETIHRRLNDS SASVKDAILD LVSINSSYFE FYQQINNNYN 300
  301 DDSIMVRKHV LRINEKMYDE TNDIVTKVYV IARILMKIED EEDNIIDMAR LILLNRWILK 360
  361 VHEVLDQPEK LKEISSSVLL VMSRVAIMNE KCSQLFDLFL NFYLLNKEAH SKEAYDKITH 420
  421 VLTILTDFLV QKIVELNSDD TNEKNSIVDK QNFLNLLAKF ADSTVSFLTK DHITALYPYM 480
  481 VSDEKSDFHY YILQVFRCTF EKLANFKQKF LYDLETTLLS RLPKMNVREI DEAMPLIWSV 540
  541 ATHRHDTARV AKACSSCLSH LHPYINKANN EEAAIVVDGK LQRLIYLSTG FARFCFPKPS 600
  601 NDKIAFLQEG ETLYEHITKC LLVLSKDKIT HVIRRVAVKN LTKLCGNHPK LFNSRHVLHL 660
  661 LDKEFQSDQL DIKLVILESL YDLFLLEERK SVRNTGVNST LSSNSILKKK LLKTNRVEFA 720
  721 NDGVCSALAT RFLDNILQLC LLRDLKNSLV AIRLLKLILK FGYTNPSHSI PTVIALFAST 780
  781 SQYIRHVAYE LLEDLFEKYE TLVFSSLSRG VTKAIHYSIH TDEKYYYKH

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.13
Match: 2ie3A
Description: No description for 2ie3A was found.

Predicted functions:

Term Confidence Notes
binding 2.81296846555705 bayes_pls_golite062009
protein transporter activity 2.6734690782599 bayes_pls_golite062009
protein binding 1.81870125631028 bayes_pls_golite062009
nucleic acid binding 1.78701774446386 bayes_pls_golite062009
transporter activity 1.44589191111517 bayes_pls_golite062009
substrate-specific transporter activity 1.19535295481088 bayes_pls_golite062009
transcription regulator activity 1.08645493064764 bayes_pls_golite062009
DNA binding 0.956143892328242 bayes_pls_golite062009
protein transmembrane transporter activity 0.824035252349223 bayes_pls_golite062009
structure-specific DNA binding 0.384349606267362 bayes_pls_golite062009
transcription factor activity 0.371244009721798 bayes_pls_golite062009
RNA binding 0.369141052569571 bayes_pls_golite062009
transmembrane transporter activity 0.338017015160581 bayes_pls_golite062009
signal sequence binding 0.262155773896291 bayes_pls_golite062009
nuclear localization sequence binding 0.19122877456451 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.0946244209704199 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [1310-1493]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DHFLSLLEKL CGTGKKNGPK FFKVLKRIMQ SYLDDITDLT STNSSVQKSI FVLCTNISNI  60
   61 TFVSQYDLVS LLKTIDLTTD RLKEVIMDEI GDNVSSLSVS EEKLSGIILI QLSLQDLGTY 120
  121 LLHLYGLRDD VLLLDIVEES ELKNKQLPAK KPDISKFSAQ LENIEQYSSN GKLLTYFRKH 180
  181 VKDT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle