| Protein: | GIS1 |
| Organism: | Saccharomyces cerevisiae |
| Length: | 894 amino acids |
| Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GIS1.
| Description | E-value | Query Range |
Subject Range |
|
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0.0 | [1..894] | [1..894] |
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|
0.0 | [247..893] | [359..1056] |
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0.0 | [299..893] | [244..826] |
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0.0 | [335..893] | [16..628] |
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Region A: Residues: [1-79] |
1 11 21 31 41 51
| | | | | |
1 MEIKPVEVID GVPVFKPSMM EFANFQYFID EITKFGIENG IVKVIPPKEW LELLEGSPPA 60
61 ESLKTIQLDS PIQQQAKRW
|
| Detection Method: |  |
| Confidence: | 28.508638 |
| Match: | PF02375 |
| Description: | jmjN domain |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
|
Region A: Residues: [80-136] |
1 11 21 31 41 51
| | | | | |
1 DKHENGVFSI ENEYDNKSYN LTQWKNLAES LDSRISQGDF NDKTLKENCR VDSQQDC
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| Detection Method: | |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
| MCM Score |
SCOP Match |
SCOP Description | ||
| View | Download | 0.424 | a.8.1 | Bacterial immunoglobulin/albumin-binding domains |
| View | Download | 0.670 | a.5.1 | DNA helicase RuvA subunit, C-terminal domain |
| View | Download | 0.482 | a.164.1 | C-terminal domain of DFF45/ICAD (DFF-C domain) |
| View | Download | 0.490 | a.52.1 | Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin |
| View | Download | 0.462 | a.57.1 | Protein HNS-dependent expression A; HdeA |
| View | Download | 0.448 | a.22.1 | Histone-fold |
| View | Download | 0.442 | a.29.4 | RecG, N-terminal domain |
| View | Download | 0.374 | d.47.1 | Ribosomal protein L11, N-terminal domain |
| View | Download | 0.365 | a.5.1 | DNA helicase RuvA subunit, C-terminal domain |
| View | Download | 0.356 | a.44.1 | Disulphide-bond formation facilitator (DSBA), insertion domain |
| View | Download | 0.331 | a.32.1 | Transcription factor IIA (TFIIA), alpha-helical domain |
| View | Download | 0.298 | a.16.1 | S15/NS1 RNA-binding domain |
| View | Download | 0.270 | d.58.17 | Metal-binding domain |
| View | Download | 0.242 | a.44.1 | Disulphide-bond formation facilitator (DSBA), insertion domain |
| View | Download | 0.231 | a.24.13 | Domain of the SRP/SRP receptor G-proteins |
| View | Download | 0.228 | a.32.1 | Transcription factor IIA (TFIIA), alpha-helical domain |
| View | Download | 0.227 | a.44.1 | Disulphide-bond formation facilitator (DSBA), insertion domain |
| View | Download | 0.215 | a.52.1 | Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin |
| View | Download | 0.214 | a.5.6 | Hypothetical protein MTH1615 |
|
Region A: Residues: [137-307] |
1 11 21 31 41 51
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1 YDLAQLQILE SDFWKTIAFS KPFYAVDENS SIFPYDLTLW NLNNLPDSIN SSNRRLLTGQ 60
61 SKCIFPWHLD EQNKCSINYL HFGAPKQWYS IPSANTDQFL KILSKEPSSN KENCPAFIRH 120
121 QNIITSPDFL RKNNIKFNRV VQFQHEFIIT FPYCMYSGFN YGYNFGESIE F
|
| Detection Method: | |
| Confidence: | 50.327902 |
| Match: | PF02373 |
| Description: | JmjC domain |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
| Term | Confidence | Notes |
| nucleic acid binding | 2.97176528779183 | bayes_pls_golite062009 |
| binding | 2.95955830245165 | bayes_pls_golite062009 |
| DNA binding | 2.78082210591574 | bayes_pls_golite062009 |
| transcription regulator activity | 2.53889200428466 | bayes_pls_golite062009 |
| chromatin binding | 2.17816148863289 | bayes_pls_golite062009 |
| transcription factor activity | 1.71320052881408 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 1.03479741823043 | bayes_pls_golite062009 |
| protein binding | 1.02778071153188 | bayes_pls_golite062009 |
| transcription activator activity | 0.90850120023053 | bayes_pls_golite062009 |
| histone binding | 0.687710658383448 | bayes_pls_golite062009 |
| transcription repressor activity | 0.373557406294709 | bayes_pls_golite062009 |
| catalytic activity | 0.245893663605433 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 0.2354474590082 | bayes_pls_golite062009 |
| transcription factor binding | 0.1746219785248 | bayes_pls_golite062009 |
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Region A: Residues: [308-395] |
1 11 21 31 41 51
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1 ILDQQAVVRK QPLKCGCGNK KEERKSGPFS NLSYDSNESE QRGSITDNDN DLFQKVRSFD 60
61 ELLNHSSQEL QNLEDNKNPL FSNINMNR
|
| Detection Method: | |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
| MCM Score |
GO Score |
GO Term |
SCOP Match |
SCOP Description | ||
| View | Download | 0.253 | 0.027 | phospholipid metabolic process | a.2.3 | Chaperone J-domain |
| View | Download | 0.238 | 0.006 | phospholipid metabolic process | a.37.1 | A DNA-binding domain in eukaryotic transcription factors |
| View | Download | 0.216 | 0.003 | phospholipid metabolic process | d.58.44 | Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains |
|
Region A: Residues: [396-465] |
1 11 21 31 41 51
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1 PQSSSLRSTT PNGVNQFLNM NQTTISRISS PLLSRMMDLS NIVEPTLDDP GSKFKRKVLT 60
61 PQLPQMNIPS
|
| Detection Method: | |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
| MCM Score |
SCOP Match |
SCOP Description | ||
| View | Download | 0.448 | a.22.1 | Histone-fold |
| View | Download | 0.490 | a.52.1 | Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin |
| View | Download | 0.462 | a.57.1 | Protein HNS-dependent expression A; HdeA |
| View | Download | 0.442 | a.29.4 | RecG, N-terminal domain |
| View | Download | 0.356 | a.44.1 | Disulphide-bond formation facilitator (DSBA), insertion domain |
| View | Download | 0.355 | a.52.1 | Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin |
| View | Download | 0.323 | a.64.2 | Bacteriocin AS-48 |
| View | Download | 0.323 | a.24.13 | Domain of the SRP/SRP receptor G-proteins |
| View | Download | 0.316 | a.52.1 | Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin |
| View | Download | 0.299 | a.64.1 | Saposin |
| View | Download | 0.274 | a.56.1 | CO dehydrogenase ISP C-domain like |
| View | Download | 0.263 | a.4.1 | Homeodomain-like |
| View | Download | 0.259 | a.46.2 | Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain |
| View | Download | 0.258 | a.12.1 | Kix domain of CBP (creb binding protein) |
| View | Download | 0.258 | a.5.1 | DNA helicase RuvA subunit, C-terminal domain |
| View | Download | 0.257 | a.48.3 | Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 |
| View | Download | 0.234 | a.60.9 | lambda integrase-like, N-terminal domain |
| View | Download | 0.232 | a.21.1 | HMG-box |
| View | Download | 0.229 | a.101.1 | Uteroglobin-like |
| View | Download | 0.222 | a.58.1 | Chemotaxis receptor methyltransferase CheR, N-terminal domain |
| View | Download | 0.214 | a.28.1 | ACP-like |
| View | Download | 0.211 | a.74.1 | Cyclin-like |
| View | Download | 0.210 | a.112.1 | Description not found. |
| View | Download | 0.210 | a.7.6 | Ribosomal protein S20 |
| View | Download | 0.207 | a.46.1 | Methionine synthase domain |
| View | Download | 0.205 | f.15.1 | Small-conductance potassium channel |
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Region A: Residues: [466-615] |
1 11 21 31 41 51
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1 NSSNFGTPSL TNTNSLLSNI TATSTNPSTT TNGSQNHNNV NANGINTSAA ASINNNISST 60
61 NNSANNSSSN NNVSTVPSSM MHSSTLNGTS GLGGDNDDNM LALSLATLAN SATASPRLTL 120
121 PPLSSPMNPN GHTSYNGNMM NNNSGNGSNG
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| Detection Method: | |
| Confidence: | 17.69897 |
| Match: | 2gliA_ |
| Description: | Five-finger GLI1 |
Matching Structure (courtesy of the PDB): |
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Region A: Residues: [616-694] |
1 11 21 31 41 51
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1 SNSYSNGVTT AAATTTSAPH NLSIVSPNPT YSPNPLSLYL TNSKNPLNSG LAPLSPSTSN 60
61 IPFLKRNNVV TLNISREAS
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| Detection Method: | |
| Confidence: | 89.24799 |
| Match: | 1a1iA_ |
| Description: | ZIF268 |
Matching Structure (courtesy of the PDB): |
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Region A: Residues: [695-775] |
1 11 21 31 41 51
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1 KSPISSFVND YRSPLGVSNP LMYSSTINDY SNGTGIRQNS NNINPLDAGP SFSPLHKKPK 60
61 ILNGNDNSNL DSNNFDYSFT G
|
| Detection Method: | |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
| MCM Score |
GO Score |
GO Term |
SCOP Match |
SCOP Description | ||
| View | Download | 0.345 | 0.030 | phospholipid metabolic process | a.74.1 | Cyclin-like |
| View | Download | 0.578 | 0.025 | phospholipid metabolic process | a.60.2 | RuvA domain 2-like |
| View | Download | 0.453 | 0.023 | phospholipid metabolic process | a.56.1 | CO dehydrogenase ISP C-domain like |
| View | Download | 0.388 | N/A | N/A | a.44.1 | Disulphide-bond formation facilitator (DSBA), insertion domain |
| View | Download | 0.291 | N/A | N/A | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.275 | N/A | N/A | a.24.13 | Domain of the SRP/SRP receptor G-proteins |
| View | Download | 0.272 | N/A | N/A | a.76.1 | Iron-dependent represor protein, dimerization domain |
| View | Download | 0.245 | N/A | N/A | a.22.1 | Histone-fold |
| View | Download | 0.237 | N/A | N/A | d.26.1 | FKBP-like |
| View | Download | 0.236 | N/A | N/A | a.46.2 | Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain |
| View | Download | 0.234 | N/A | N/A | a.60.12 | DNA polymerase beta-like, second domain |
| View | Download | 0.228 | N/A | N/A | a.60.13 | Putative methyltransferase TM0872, insert domain |
| View | Download | 0.212 | N/A | N/A | a.74.1 | Cyclin-like |
| View | Download | 0.206 | N/A | N/A | a.70.1 | N-terminal domain of the delta subunit of the F1F0-ATP synthase |
| View | Download | 0.201 | N/A | N/A | a.44.1 | Disulphide-bond formation facilitator (DSBA), insertion domain |
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Region A: Residues: [776-848] |
1 11 21 31 41 51
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1 NKQESNPSIL NNNTNNNDNY RTSSMNNNGN NYQAHSSKFG ENEVIMSDHG KIYICRECNR 60
61 QFSSGHHLTR HKK
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| Detection Method: | |
| Confidence: | 2.69897 |
| Match: | 2drpA_ |
| Description: | Tramtrack protein (two zinc-finger peptide) |
Matching Structure (courtesy of the PDB): |
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Region A: Residues: [849-894] |
1 11 21 31 41 51
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1 SVHSGEKPHS CPRCGKRFKR RDHVLQHLNK KIPCTQEMEN TKLAES
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| Detection Method: | |
| Confidence: | 78.30103 |
| Match: | 2adr__ |
| Description: | ADR1 |
Matching Structure (courtesy of the PDB): |
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