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View Structure Prediction Details

Protein: MATALPHA1, HMLALPHA1
Organism: Saccharomyces cerevisiae
Length: 175 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MATALPHA1, HMLALPHA1.

Description E-value Query
Range		 Subject
Range
MATALPHA1, HMLALPHA1 - Transcriptional co-activator involved in regulation of mating-type-specific gene expression; targets...
MTAL1_YEAST, HMA... - Mating-type protein ALPHA1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MATALPHA1 PE=...
gi|190406385 - gi|190406385|gb|EDV09652.1| MTAL1_YEAST?Mating-type?protein?ALPHA1 [Saccharomyces cerevisiae RM11-1a...
 5.0E-63 [1..175] [1..175]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 4.0E-42 [1..157] [1..171]
MAT1_COCHE - Mating-type protein MAT-1 OS=Cochliobolus heterostrophus GN=MAT1 PE=3 SV=1
 4.0E-27 [53..144] [31..117]
gi|447739 - gi|447739|prf||1915304A nylB upstream ORF
 1.0E-26 [53..144] [31..117]
MAT1_COCCA - Mating-type protein MAT-1 OS=Cochliobolus carbonum GN=MAT1 PE=3 SV=1
 1.0E-26 [53..144] [31..117]
MATA_NEUCR - Mating-type protein A-1 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257...
MATA_NEUCR - Mating-type protein A-1 OS=Neurospora crassa GN=mtA-1 PE=1 SV=2
 2.0E-26 [86..175] [40..115]
MAT1_COCCY - Mating-type protein MAT-1 OS=Cochliobolus cymbopogonis GN=MAT1 PE=3 SV=1
 5.0E-26 [53..144] [31..117]
MAT1_COCEL - Mating-type protein MAT-1 OS=Cochliobolus ellisii GN=MAT1 PE=3 SV=1
 5.0E-26 [53..144] [31..117]
MAT1_COCSA - Mating-type protein MAT-1 OS=Cochliobolus sativus GN=MAT1 PE=3 SV=1
 6.0E-26 [53..144] [31..117]
gi|4928164 - gi|4928164|gb|AAD33439.1|AF129740_2 mating type protein MAT-1/2 [Cochliobolus luttrellii]
 1.0E-25 [53..144] [31..117]

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Predicted Domain #1
Region A:
Residues: [1-175] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFTSKPAFKI KNKASKSYRN TAVSKKLKEK RLAEHVRPSC FNIIRPLKKD IQIPVPSSRF  60
   61 LNKIQIHRIA SGSQNTQFRQ FNKTSIKSSK KYLNSFMAFR AYYSQFGSGV KQNVLSSLLA 120
  121 EEWHADKMQH GIWDYFAQQY NFINPGFGFV EWLTNNYAEV RGDGYWEDVF VHLAL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
DNA binding 4.84246149108405 bayes_pls_golite062009
nucleic acid binding 4.73451137188048 bayes_pls_golite062009
transcription regulator activity 4.70526716815828 bayes_pls_golite062009
transcription factor activity 3.57291699480776 bayes_pls_golite062009
binding 3.45976454780353 bayes_pls_golite062009
sequence-specific DNA binding 2.64790748689391 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.54168984559574 bayes_pls_golite062009
transcription activator activity 1.46271038594364 bayes_pls_golite062009
chromatin binding 1.42879477692352 bayes_pls_golite062009
transcription repressor activity 1.35292098889847 bayes_pls_golite062009
protein binding 1.06660874927515 bayes_pls_golite062009
transcription factor binding 0.97374076531363 bayes_pls_golite062009
four-way junction DNA binding 0.646384703124195 bayes_pls_golite062009
DNA bending activity 0.428738547626155 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.0671309267769598 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle