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View Structure Prediction Details

Protein: PDB1
Organism: Saccharomyces cerevisiae
Length: 366 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PDB1.

Description E-value Query
Range
Subject
Range
ODPB_YEAST - Pyruvate dehydrogenase E1 component subunit beta, mitochondrial OS=Saccharomyces cerevisiae (strain ...
PDB1 - E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved mu...
0.0 [1..366] [1..366]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [34..364] [7..337]
gi|4505687, gi|1... - gi|4505687|ref|NP_000916.1| pyruvate dehydrogenase (lipoamide) beta [Homo sapiens], gi|219984|dbj|BA...
0.0 [5..365] [7..359]
ODPB_ASCSU - Pyruvate dehydrogenase E1 component subunit beta, mitochondrial OS=Ascaris suum PE=1 SV=1
0.0 [39..366] [34..361]

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Predicted Domain #1
Region A:
Residues: [1-231]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFSRLPTSLA RNVARRAPTS FVRPSAAAAA LRFSSTKTMT VREALNSAMA EELDRDDDVF  60
   61 LIGEEVAQYN GAYKVSKGLL DRFGERRVVD TPITEYGFTG LAVGAALKGL KPIVEFMSFN 120
  121 FSMQAIDHVV NSAAKTHYMS GGTQKCQMVF RGPNGAAVGV GAQHSQDFSP WYGSIPGLKV 180
  181 LVPYSAEDAR GLLKAAIRDP NPVVFLENEL LYGESFEISE EALSPEFTLP Y

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 626.855515
Match: 1ik6A_
Description: E1-beta subunit of pyruvate dehydrogenase, Pyr module; E1-beta subunit of pyruvate dehydrogenase, C-domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
pyruvate dehydrogenase activity 11.3856674722026 bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity 11.0549577473177 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor 10.8180381281695 bayes_pls_golite062009
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity 7.00951713446616 bayes_pls_golite062009
alpha-ketoacid dehydrogenase activity 6.25236550086321 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors 5.65146926050423 bayes_pls_golite062009
acetolactate synthase activity 4.51986503762195 bayes_pls_golite062009
cyclin-dependent protein kinase 5 activator regulator activity 3.00128844859152 bayes_pls_golite062009
2-oxoisovalerate dehydrogenase (acylating) activity 3.00128844859152 bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups 2.21959520697519 bayes_pls_golite062009
transketolase activity 2.20554088536433 bayes_pls_golite062009
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer 0.667418924427388 bayes_pls_golite062009
binding 0.551586872853971 bayes_pls_golite062009
catalytic activity 0.545407789079971 bayes_pls_golite062009
oxidoreductase activity 0.281475773435032 bayes_pls_golite062009
pyruvate decarboxylase activity 0.198062360371269 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [232-366]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KAKIEREGTD ISIVTYTRNV QFSLEAAEIL QKKYGVSAEV INLRSIRPLD TEAIIKTVKK  60
   61 TNHLITVEST FPSFGVGAEI VAQVMESEAF DYLDAPIQRV TGADVPTPYA KELEDFAFPD 120
  121 TPTIVKAVKE VLSIE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 626.855515
Match: 1ik6A_
Description: E1-beta subunit of pyruvate dehydrogenase, Pyr module; E1-beta subunit of pyruvate dehydrogenase, C-domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle