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View Structure Prediction Details

Protein: MIS1
Organism: Saccharomyces cerevisiae
Length: 975 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MIS1.

Description E-value Query
Range		 Subject
Range
C1TM_SCHPO - C-1-tetrahydrofolate synthase, mitochondrial OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) ...
ade9 - C-1-tetrahydrofolatesynthase /methylenetetrahydrofolatedehydrogenase /methylenetetrahydrofolatecyclohy...
 0.0 [30..974] [28..968]
C1TC_RAT - C-1-tetrahydrofolate synthase, cytoplasmic OS=Rattus norvegicus GN=Mthfd1 PE=1 SV=3
 0.0 [35..975] [4..935]
gi|9992889, gi|4... - gi|9992889|gb|AAG11417.1|AF291429_1 C1-THFS protein [Yarrowia lipolytica], gi|49649268|emb|CAG78978....
gi|50551849, gi|... - gi|50551849|ref|XP_503399.1| YALI0E01056p [Yarrowia lipolytica], gi|49649268|emb|CAG78978.1| YlC1-TH...
 0.0 [34..975] [1..937]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [35..975] [4..935]
gi|151943480 - gi|151943480|gb|EDN61791.1| RNA polymerase C1-tetrahydrofolate synthase [Saccharomyces cerevisiae YJ...
ADE3 - Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism ...
C1TC_YEAST - C-1-tetrahydrofolate synthase, cytoplasmic OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ...
 0.0 [36..975] [4..946]
C1TC_MOUSE - C-1-tetrahydrofolate synthase, cytoplasmic OS=Mus musculus GN=Mthfd1 PE=1 SV=3
 0.0 [35..975] [4..935]

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Predicted Domain #1
Region A:
Residues: [1-47] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSRLSLLSN SRAFQQARWR IYRLKVSPTV HASQYHILSG RKLAQSI

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [159-310] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YNAGELAKKG GKPYFIPCTP YGCMKLLEEA HVKLDGKNAV VLGRSSIVGN PIASLLKNAN  60
   61 ATVTVCHSHT RNIAEVVSQA DIVIAACGIP QYVKSDWIKE GAVVIDVGIN YVPDISKKSG 120
  121 QKLVGDVDFD SVKEKTSYIT PVPGGVGPMT VA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 844.0
Match: 1diaA_
Description: Methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Tetrahydrofolate dehydrogenase/cyclohydrolase
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [48-158] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 REKANDEIQA IKLKHPNFKP TLKIIQVGAR PDSSTYVRMK LKASKDSNVD CIIEKLPAEI  60
   61 TEVELLKKIS DINDDDSIHG LLIQLPLPRH LDETTITNAV DFKKDVDGFH R

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [311-336] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLVSNVLLAA KRQFVESEKL PVIKPL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 844.0
Match: 1diaA_
Description: Methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Tetrahydrofolate dehydrogenase/cyclohydrolase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.64537357529343 bayes_pls_golite062009
nucleic acid binding 2.51683451033161 bayes_pls_golite062009
translation initiation factor activity 2.41232228963167 bayes_pls_golite062009
DNA binding 2.12258000781149 bayes_pls_golite062009
transcription regulator activity 2.09345198747025 bayes_pls_golite062009
lysine N-acetyltransferase activity 1.55478124277326 bayes_pls_golite062009
histone acetyltransferase activity 1.55478124277326 bayes_pls_golite062009
hydrolase activity 1.29060292615008 bayes_pls_golite062009
purine ribonucleotide binding 1.1110976601505 bayes_pls_golite062009
ribonucleotide binding 1.11103644113672 bayes_pls_golite062009
purine nucleotide binding 1.1086792521709 bayes_pls_golite062009
nucleotide binding 1.1060655022247 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
transcription factor activity 0.887108427603557 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 0.854899277460172 bayes_pls_golite062009
RNA helicase activity 0.81256037545135 bayes_pls_golite062009
ATP binding 0.80197288940364 bayes_pls_golite062009
adenyl ribonucleotide binding 0.770085840885632 bayes_pls_golite062009
adenyl nucleotide binding 0.751575230566049 bayes_pls_golite062009
RNA-dependent ATPase activity 0.74918137191219 bayes_pls_golite062009
structural constituent of ribosome 0.738234102557832 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 0.694120974355463 bayes_pls_golite062009
ATP-dependent RNA helicase activity 0.69117331267457 bayes_pls_golite062009
N-acyltransferase activity 0.581315571752634 bayes_pls_golite062009
N-acetyltransferase activity 0.487240078246257 bayes_pls_golite062009
kinase activity 0.431162005044036 bayes_pls_golite062009
ligase activity 0.417681194526243 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 0.347619818489809 bayes_pls_golite062009
translation regulator activity 0.29096092258568 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.274994961137851 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.250756824614616 bayes_pls_golite062009
acetyltransferase activity 0.190660928077915 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity 0.12351419478929 bayes_pls_golite062009
helicase activity 0.0775311459068899 bayes_pls_golite062009
structural molecule activity 0.0558641287316701 bayes_pls_golite062009
RNA binding 0.0261282189186349 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [337-398] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLHLESPVPS DIDISRAQSP KHIKQVAEEL GIHSHELELY GHYKAKISPN IFKRLESREN  60
   61 GK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [417-707] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TTMGLVQALS AHLGKPSIAN VRQPSLGPTL GVKGGAAGGG YAQVIPMDEF NLHLTGDIHA  60
   61 ISAANNLLAA AIDTRMFHEA TQKNDSTFYK RLVPRKKGIR KFTPSMQRRL KRLDIEKEDP 120
  121 DALTPEEVKR FARLNINPDT ITIRRVVDIN DRMLRQITIG EAATEKGFTR TTGFDITVAS 180
  181 ELMAILALSK SLHEMKERIG RMVIGADYDN KPVTVEDIGC TGALTALLRD AIKPNLMQTL 240
  241 EGTPVMVHAG PFANISIGAS SVIADLMALK LVGSEKNPLN DKNIHEPGYV V

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [949-975] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QTIPGLSTYA GYMAVEVDDD GEIEGLF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2420.0
Match: 1fp7A_
Description: Formyltetrahydrofolate synthetase
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [399-416] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YVLVAGITPT PLGEGKST

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [708-948] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TEAGFDFAMG GERFFDIKCR SSGLVPDAVV LVATVRALKS HGGAPNVKPG QSLPKEYTEE  60
   61 NIDFVAKGVS NLVKQIENIK TFGIPVVVAI NRFETDSQAE IEVIKKAALN AGASHAVTSN 120
  121 HWMEGGKGAV ELAHAVVDAT KEPKNFNFLY DVNSSIEDKL TSIVQKMYGG AKIEVSPEAQ 180
  181 KKIDTYKKQG FGNLPICIAK TQYSLSHDPS LKGVPRGFTF PIRDVRASIG AGYLYALAAE 240
  241 I

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2420.0
Match: 1fp7A_
Description: Formyltetrahydrofolate synthetase
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle